Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 126 - 126

Published: Jan. 18, 2025

Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations environmental stressors, on one hand, cancer cell structure, functioning, behavior. Aberrant PTMs can be considered as enabling characteristics long they orchestrate all malignant variability in proteome cells, cancer-associated tumor microenvironment (TME). On other enhance anticancer mechanisms tumoral ecosystem or sustain beneficial effects oncologic therapies through degradation inactivation carcinogenic or/and activation tumor-suppressor proteins. In this review, we summarized analyzed a wide spectrum involved regulatory that drive tumorigenesis, genetic instability, epigenetic reprogramming, events metastatic cascade, cytoskeleton extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, metabolism rewiring most important hallmarks cancer. All develop due to proteins, which modulate gene transcription, intracellular signaling, protein size, activity, stability localization, trafficking, secretion, half-life, protein–protein interactions (PPIs). associated with exploited better understand underlying molecular heterogeneous chameleonic disease, find new biomarkers progression prognosis, personalize oncotherapies, discover targets for drug development.

Language: Английский

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Traditional Chinese medicine in lung cancer treatment

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Language: Английский

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GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 17, 2025

Epidermal growth factor receptor (EGFR) is a major oncogenic protein, and thus EGFR-targeting therapies are widely used in patients with various types of cancer, including lung cancer. However, resistance to EGFR inhibitors, such as erlotinib, presents significant challenge treating In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype cancer A549 cells by exposing them erlotinib for extended period. The resulting ER exhibited dramatic increase resistance, decreased protein level, enhanced tumor growth, suggesting robust mechanism bypassing inhibition. RNA sequencing identified the transcription GRHL2 critical player resistance. was upregulated cells, its knockdown knockout significantly reduced Further analysis revealed that upregulates tyrosine kinase HER3, HER3 similarly decreases IC50 erlotinib. Additionally, showed increased cell-cell adhesion, linked E-cadherin. E-cadherin found be vital largely independent GRHL2, highlighting multiple parallel pathways sustaining These findings provide novel drug suggest combination targeting both GRHL2-HER3 E-cadherin-mediated may necessary overcome

Language: Английский

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Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 30, 2025

Transarterial chemoembolization (TACE) is the first-line therapeutic option for patients with intermediate-stage hepatocellular carcinoma (HCC). Tumor neovascularization allows tumor growth and may facilitate release of circulating cells (CTCs) to bloodstream after TACE. We investigated relationship between early CTCs radiological response Prospective, single-center study including HCC undergoing a first TACE from January 2019 June 2023. The IsoFlux® system was used evaluate EpCAM+ CTC counts before TACE, at day 1 (D1), 30 Radiological assessed according mRECIST criteria one month procedure. vascularity by an interventional radiologist. In all, 48 were included (age 64.2 ± 7.6 years, 14.6% women). levels increased D1 (114.0% [IQR 76.5%-178.0%], p = 0.019) normalized baseline in (76.5% 41.3%-131.8%], 0.263). Higher (p 0.009) 0.026) associated hypervascularity. Larger size [OR: 1.9 (95% CI: 1.1–3.3), 0.020] increase 5.3 1.3–21.0), 0.017] independent predictors non-response especially those hypervascular lesions. A meaningful 24 h suboptimal Future studies should role dynamics select candidates adjuvant therapy analyze their impact on long-term outcomes.

Language: Английский

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Multifaceted Approaches in Epithelial Cell Adhesion Molecule-Mediated Circulating Tumor Cell Isolation

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 976 - 976

Published: Feb. 20, 2025

Circulating tumor cells (CTCs) are pivotal in cancer metastasis and serve as valuable biomarkers for diagnosis, prognosis, treatment monitoring. Traditional CTC capture methods predominantly utilize the epithelial cell adhesion molecule (EpCAM) a marker isolation. However, heterogeneity of these circulating epithelial-to-mesenchymal transition process (wherein acquire mesenchymal characteristics) limit efficacy EpCAM-based techniques. In this paper, we critically review role EpCAM capture, explore impact on expression, discuss alternative strategies to enhance By evaluating limitations EpCAM-mediated challenges posed by transition, aim provide insights into development more comprehensive liquid biopsy approaches management.

Language: Английский

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Targeting the tumour cell surface in advanced prostate cancer

Nature Reviews Urology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Rhythm is essential: Unraveling the relation between the circadian clock and cancer

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104632 - 104632

Published: Jan. 1, 2025

Language: Английский

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Appendiceal cancer in pregnancy and circulating tumor cells detection in the umbilical cord

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42411 - e42411

Published: Feb. 1, 2025

Although malignant tumors metastasizing to infant or the placenta are occasionally reported during pregnancy, adverse effects of maternal on fetus have not been clarified. Due rarity appendiceal cancer tumor pregnancy Herein, we report a 30-year-old woman who experienced (stage IVC) wherein metastatic ovarian was detected pregnancy. A bilateral salpingo-oophorectomy and partial resection omentum were performed at 25 weeks 6 days gestational age (GA), followed by Cesarean section 30 1 day GA. Postpartum chemotherapy with fluorouracil, oxaliplatin, levofolinate calcium could sufficiently control her disease. Purpura observed all over body birth. The neonatal disseminated intravascular coagulation score 4 according scoring system used Japanese Society Obstetrical, Gynecological & Neonatal Hematology, which meet criteria. Detailed histopathological examination did detect any cells in umbilical cord. Moreover, no other abnormalities found based comprehensive medical evaluation infant. However, circulating (CTCs) both cord blood samples from patient. Collectively, this case might be first step into studying circulation CTCs through via its fetal outcome; worsened condition. More advanced analysis would useful for predicting negative future.

Language: Английский

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Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Bladder cancer (BC) is a malignant tumor characterized by high incidence of urinary system diseases. The complex pathogenesis BC has long been focal point in medical research. With the robust development epigenetics, crucial role epigenetic modifications occurrence and progression elucidated. These not only affect gene expression but also impact critical biological behaviors cells, including proliferation, differentiation, apoptosis, invasion, metastasis. Notably, DNA methylation, an important regulatory mechanism, often manifests as global hypomethylation or hypermethylation specific promoter regions BC. Alterations this methylation pattern can lead to increased genomic instability, which profoundly influences proto-oncogenes suppressor genes. MiRNAs, noncoding small RNAs, participate various processes regulating target Consequently, work aims explore interaction mechanisms between miRNAs Research demonstrated that directly miRNA genes indirectly affects maturation functionality modulating status regions. Simultaneously, regulate levels targeting key enzymes such methyltransferases (DNMTs), thereby establishing feedback network. A deeper understanding crosstalk will contribute elucidating complexity dynamics disease, may provide new molecular targets strategies for early diagnosis, treatment, prognostic evaluation

Language: Английский

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Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single‐Atom Nanozyme Integrated 3D Nanoarray

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Late-stage diagnosis is a major contributor to cancer mortality and thus leads increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers the identification of aggressive cancers. Here, develop single-atom nanozyme integrated nanoarray 3D nano-biointerface ultrasensitive electrochemical screening CTCs from hepatocellular carcinoma. This cytosensor capable identifying CTC at single-cell level, achieving an impressive area under curve 0.96 in receiver operating characteristics, comparable simulated multi-indicator diagnostic strategies. strategy shows great potential non-invasive carcinoma promising be applied universally diagnosis.

Language: Английский

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