Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 22, 2022

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and immune system is impaired, subsequent effects can be triggered on skin, potentially promoting development of skin diseases. mechanisms through which affects health are still unclear. Enhancing our understanding connection needed to find novel ways treat disorders. In this review, we systematically evaluate current data regarding ecology healthy gut, diet, pre- probiotics, antibiotics, their health. We discuss potential axis link skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa. This review will increase impacts conditions aid finding new medications for

Language: Английский

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Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(6), P. 1064 - 1078

Published: May 15, 2023

Language: Английский

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A metagenomic catalog of the early-life human gut virome

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 29, 2024

Early-life human gut microbiome is a pivotal driver of homeostasis and infant health. However, the viral component (known as "virome") remains mostly unexplored. Here, we establish Early-Life Gut Virome (ELGV), catalog 160,478 non-redundant DNA RNA sequences from 8130 virus-like particles (VLPs) enriched or bulk metagenomes in first three years life. By clustering, 82,141 species are identified, 68.3% which absent existing databases built mainly adults, 64 8 based on VLPs-enriched metagenomes, respectively, exhibit potentials biomarkers to distinguish infants adults. With largest longitudinal population profiled by either metagenomic sequencing, track inherent instability temporal development early-life virome, identify differential viruses associated with multiple clinical factors. The mother-infant shared virome interactions between bacteriome early life further expanded. Together, ELGV provides most comprehensive complete blueprint facilitating discovery pediatric disease-virome associations future.

Language: Английский

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Longitudinal phage–bacteria dynamics in the early life gut microbiome

Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

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Bacteriophages playing nice: Lysogenic bacteriophage replication stable in the human gut microbiota

iScience, Journal Year: 2023, Volume and Issue: 26(2), P. 106007 - 106007

Published: Jan. 18, 2023

Bacteriophages, viruses specific to bacteria, coexist with their bacterial hosts limited diversity fluctuations in the guts of healthy individuals where they replicate mostly via lysogenic replication. This favors 'piggy-back-the-winner' over 'kill-the-winner' dynamics which are driven by lytic bacteriophage Revisiting deep-viral sequencing data a individual sampled 2.4 years, we explore how these occur. Prophages found assembled metagenomes were also extra-cellularly, as induced phage particles (iPPs), likely derived from prophage activation. These iPPs diverse and continually present low abundance, relative highly abundant but less population. The continuous detection levels suggests that spontaneous induction regularly occurs this individual, possibly allowing prophages maintain ability avoiding degradation loss gut microbiota.

Language: Английский

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Engineered Bacillus subtilis for the de novo production of 2′-fucosyllactose

Microbial Cell Factories, Journal Year: 2022, Volume and Issue: 21(1)

Published: June 2, 2022

The most abundant human milk oligosaccharide in breast milk, 2'-fucosyllactose (2'-FL), has been approved as an additive to infant formula due its multifarious nutraceutical and pharmaceutical functions promoting neonate health. However, the low efficiency of de novo synthesis limits cost-efficient bioproduction 2'-FL.This study achieved 2'-FL a generally recognized safe (GRAS) strain Bacillus subtilis. First, biosynthetic pathway for was introduced by expressing manB, manC, gmd, wcaG, futC genes from Escherichia coli Helicobacter pylori B. subtilis, resulting production 1.12 g/L. Subsequently, titer 2.57 g/L obtained reducing competitive lactose consumption, increasing regeneration cofactor guanosine-5'-triphosphate (GTP), enhancing supply precursor mannose-6-phosphate (M6P). By replacing native promoter endogenous manA gene (encoding M6P isomerase) with constitutive P7, shake flask reached 18.27 finally engineered BS21 could produce 88.3 yield 0.61 g/g 3-L bioreactor, without addition antibiotics chemical inducers.The efficient can be paving way large-scale future.

Language: Английский

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The role of virome in the gastrointestinal tract and beyond

FEMS Microbiology Reviews, Journal Year: 2022, Volume and Issue: 46(6)

Published: June 14, 2022

Abstract The human gut virome is comprised of diverse commensal and pathogenic viruses. colonization by these viruses begins right after birth through vaginal delivery, then continues breastfeeding, broader environmental exposure. Their constant interaction with their bacterial hosts in the body shapes not only our microbiomes but us. In addition, interact immune cells, trigger a broad range responses, influence different metabolic pathways. Besides its key role regulating homeostasis, intestinal contributes to disease development distant organs, both directly indirectly. this review, we will describe changes life, health, disease, followed discussing interactions between virome, microbiome, host as well providing an overview contribution organs.

Language: Английский

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The Emerging Role of the Gut Virome in Health and Inflammatory Bowel Disease: Challenges, Covariates and a Viral Imbalance

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 173 - 173

Published: Jan. 6, 2023

Virome research is a rapidly growing area in the microbiome field that increasingly associated with human diseases, such as inflammatory bowel disease (IBD). Although substantial progress has been made, major methodological challenges limit our understanding of virota. In this review, we describe must be considered to accurately report virome composition and current knowledge on health IBD. First, description shows strong biases related wetlab (e.g., VLP enrichment) bioinformatics approaches (viral identification classification). Second, IBD patients show consistent viral imbalances characterized by high relative abundance phages belonging Caudovirales low Microviridae. Simultaneously, sporadic contraction CrAss-like potential expansion lysogenic intestinal are observed. Finally, despite numerous studies have conducted diversity analysis, it difficult draw firm conclusions due biases. Overall, present many environmental factors influence virome, its consensus IBD, contributing hypothesis called “positive feedback loop” may play role pathophysiology

Language: Английский

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Infant gut DNA bacteriophage strain persistence during the first 3 years of life

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 32(1), P. 35 - 47.e6

Published: Dec. 13, 2023

Bacteriophages are key components of gut microbiomes, yet the phage colonization process in infant remains uncertain. Here, we establish a large sequence database and use strain-resolved analyses to investigate DNA succession infants throughout first 3 years life. Analysis 819 fecal metagenomes collected from 28 full-term 24 preterm their mothers revealed that early-life phageome richness increases over time reaches adult-like complexity by age 3. Approximately 9% early colonizers, which mostly maternally transmitted infect Bacteroides, persist for more prevalent than infants. Although rare, phages with stop codon reassignment likely non-recoded generally display an increase in-frame reassigned codons years. Overall, maternal seeding, reassignment, host CRISPR-Cas locus prevalence, diverse populations contribute stable viral colonization.

Language: Английский

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Role of bacteriophages in shaping gut microbial community

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 21, 2024

Phages are the most diversified and dominant members of gut virobiota. They play a crucial role in shaping structure function microbial community consequently health humans animals. found mainly mucus, from where they can translocate to intestinal organs act as modulator microbiota. Understanding vital phages regulating composition microbiota influencing human animal is an emerging area research. The relevance ecosystem supported by substantial evidence, but importance remains unclear. Although information regarding general phage ecology development has accumulated, detailed knowledge on phage-gut microbe phage-human interactions lacking, effects therapy ambiguous. In this review, we systematically assess existing data environments, their development, possible interaction, subsequent impact dynamics. We discuss potential mechanisms prophage activation modulation bacteria. also review link between immune system collect evidence effect composition. Our will improve understanding influence facilitate phage-based therapies for maintaining healthy balanced

Language: Английский

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