Early Life Stress Alters Gene Expression and Cytoarchitecture in the Prefrontal Cortex Leading to Social Impairment and Increased Anxiety DOI Creative Commons
Noriyoshi Usui,

Yuta Ono,

Ryoko Aramaki

et al.

Frontiers in Genetics, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 2, 2021

Early life stress (ELS), such as abuse, neglect, and maltreatment, exhibits a strong impact on the brain mental development of children. However, it is not fully understood how ELS affects social behaviors social-associated well developing prefrontal cortex (PFC). In this study, we performed isolation weaned pre-adolescent mice until adolescence investigated these PFC characteristics in adolescent mice. We found induced impairments novelty, interaction, preference also observed increases anxiety-like histological analysis, reduced number neurons an increased microglia To identify gene associated with behavioral features, analyzed transcriptome identified 15 differentially expressed genes involved transcriptional regulation, stress, synaptic signaling. Our study demonstrates that influences behaviors, through cytoarchitectural transcriptomic alterations

Language: Английский

Animal Models of Depression: What Can They Teach Us about the Human Disease? DOI Creative Commons
Maria Becker, Albert Pinhasov, Asher Ornoy

et al.

Diagnostics, Journal Year: 2021, Volume and Issue: 11(1), P. 123 - 123

Published: Jan. 14, 2021

Depression is apparently the most common psychiatric disease among mood disorders affecting about 10% of adult population. The etiology and pathogenesis depression are still poorly understood. Hence, as for human diseases, animal models can help us understand and, more importantly, may facilitate search therapy. In this review we first describe tests used evaluation depressive-like symptoms in rodents. Then different discuss their strengths weaknesses. These be divided into several categories: genetic models, induced by mental acute chronic stressful situations caused environmental manipulations (i.e., learned helplessness rats/mice), changes brain neuro-transmitters or specific injuries pharmacological tools. spite fact that none completely resembles depression, relevant since they mimic many features observed situation serve a powerful tool study etiology, treatment especially only few patients respond to treatment. Relevance increases also has facets possible etiologies therapies.

Language: Английский

Citations

120
The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease DOI Creative Commons
Yi Ren,

Aisouda Savadlou,

Soobin Park

et al.

Frontiers in Neuroendocrinology, Journal Year: 2023, Volume and Issue: 69, P. 101061 - 101061

Published: Feb. 8, 2023

Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. Treatments aimed improving pathology AD remain ineffective to stop disease progression. This makes detection early intervention strategies reduce future risk extremely important. Isolation and loneliness have been identified among major factors for AD. The increasing prevalence both emphasizes urgent need understand this association inform treatment. Here we present comprehensive review clinical preclinical studies that investigated social isolation as We discuss understanding mechanisms how exacerbates cognitive impairment focus on sex differences will shed light underlying regarding factor develop effective prevention or treatment strategies.

Language: Английский

Citations

57
The neuroimmune response during stress: A physiological perspective DOI Creative Commons
Hedva Haykin, Asya Rolls

Immunity, Journal Year: 2021, Volume and Issue: 54(9), P. 1933 - 1947

Published: Sept. 1, 2021

Language: Английский

Citations

63
Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them DOI Creative Commons
Alzahra J. Al Omran, Amy S. Shao, Saki Watanabe

et al.

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Jan. 4, 2022

Anxiety disorders are the most prevalent mental illnesses in U.S. and estimated to consume one-third of country's health treatment cost. Although anxiolytic therapies available, many patients still exhibit resistance, relapse, or substantial side effects. Further, due COVID-19 pandemic stay-at-home order, social isolation, fear pandemic, unprecedented times, incidence anxiety has dramatically increased. Previously, we have demonstrated dihydromyricetin (DHM), major bioactive flavonoid extracted from Ampelopsis grossedentata, exhibits properties a mouse model isolation-induced anxiety. Because GABAergic transmission modulates immune system addition inhibitory signal transmission, investigated effects short-term isolation on neuroimmune system.

Language: Английский

Citations

53
Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables DOI Creative Commons
Dmitrii D. Markov, Е. В. Новосадова

Biology, Journal Year: 2022, Volume and Issue: 11(11), P. 1621 - 1621

Published: Nov. 6, 2022

Major depressive disorder (MDD) is one of the most common mood disorders worldwide. A lack understanding exact neurobiological mechanisms depression complicates search for new effective drugs. Animal models are an important tool in approaches to treatment this disorder. All animal have certain advantages and disadvantages. We often hear that main drawback chronic unpredictable mild stress (CUMS) model its poor reproducibility, but rarely does anyone try find real causes sources such reproducibility. Analyzing articles available PubMed database, we tried identify factors may be reproducibility CUMS. Among factors, there sleep deprivation, painful stressors, social stress, difference sex age animals, different susceptibility strains, handling quality, habituation stressful various combinations physical psychological stressors CUMS protocol, influence olfactory auditory stimuli on as well possible other taken into account by researchers. assume careful inspection these will increase between laboratories allow make interpretation obtained results their comparison more adequate.

Language: Английский

Citations

48
Perinatal exposure to methadone or buprenorphine impairs hippocampal-dependent cognition and brain development in juvenile rats DOI Creative Commons

Arshman S Sahid,

Melissa J Bebbington,

Abigail Marcus

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111255 - 111255

Published: Jan. 1, 2025

Language: Английский

Citations

1
Comparative perspectives on neuropeptide function and social isolation DOI
Kenta Asahina, Moriel Zelikowsky

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders DOI
Dominic Kaul, Sibylle G. Schwab, Naguib Mechawar

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 124, P. 193 - 215

Published: Feb. 6, 2021

Language: Английский

Citations

43
Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals DOI Open Access
G. A. Grigoryan, И. В. Павлова,

М. И. Зайченко

et al.

Neuroscience and Behavioral Physiology, Journal Year: 2022, Volume and Issue: 52(5), P. 722 - 738

Published: June 1, 2022

Language: Английский

Citations

32
Cause or consequence? Understanding the role of cortisol in the increased inflammation observed in depression DOI Creative Commons
Nare Amasi-Hartoonian, Luca Sforzini, Annamaria Cattaneo

et al.

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2022, Volume and Issue: 24, P. 100356 - 100356

Published: May 3, 2022

Glucocorticoids such as cortisol are a class of steroid hormones that play an important role in co-ordinating the body's response to stress. Elevated levels and increased inflammation have frequently been reported patients with depression. The currently accepted "glucocorticoid resistance" model posits this consequence reduced sensitivity cortisol's putative anti-inflammatory action. However, opposing evidence has accumulated supports more recent model, which instead proposes possesses immune potentiating properties may thus directly cause seen Despite all this, clear explanation neuroendocrine mechanism contributes development depression is still lacking requires further investigation improved future studies.

Language: Английский

Citations

31