Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 17(9), P. 564 - 579

Published: Aug. 2, 2021

Language: Английский

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Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 108, P. 245 - 254

Published: Dec. 6, 2022

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental characterized by communication and social behavior deficits. The presence of restricted repetitive behaviors often accompanies these deficits, characteristics can range from mild to severe. past several decades have seen significant rise in the prevalence ASD. etiology ASD remains unknown; however, genetic environmental risk factors play role. Multiple hypotheses converge suggest that neuroinflammation, or at least interaction between immune neural systems, may be involved some cases groups. Repeated evidence innate dysfunction has been ASD, associated with worsening behaviors. This includes data circulating myeloid cells brain resident macrophages/microglia both human animal models. comprehensive review presents recent findings including aberrant cellular function, microglia activation.

Language: Английский

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Cortical interneurons in autism

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(12), P. 1648 - 1659

Published: Nov. 29, 2021

Language: Английский

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IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 14574 - 14574

Published: Nov. 23, 2022

Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity multiple physiological processes, including protective regenerative ones. IL-8 pro-inflammatory CXC chemokine primary function in attracting activating neutrophils, but also implicated variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over course pregnancy have been shown to participate numerous pregnancy-related events. In this review, we summarize literature data regarding their role healthy pathological pregnancies. The general information related IL-6 functions followed by overview overall expression cycling endometrium interface. Further, provide involvement establishment parturition. Finally, implication pregnancy-associated conditions, such as loss, preeclampsia, gestational diabetes mellitus infection/inflammation discussed.

Language: Английский

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Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5487 - 5487

Published: March 13, 2023

Autism spectrum disorder (ASD) is a neurodevelopmental (NDD) characterized by impairments in social communication, repetitive behaviors, restricted interests, and hyperesthesia/hypesthesia caused genetic and/or environmental factors. In recent years, inflammation oxidative stress have been implicated the pathogenesis of ASD. this review, we discuss pathophysiology ASD, particularly focusing on maternal immune activation (MIA). MIA one common risk factors for onset ASD during pregnancy. It induces an reaction pregnant mother’s body, resulting further placenta fetal brain. These negative cause developing brain subsequently behavioral symptoms offspring. addition, also effects anti-inflammatory drugs antioxidants basic studies animals clinical Our review provides latest findings new insights into involvements

Language: Английский

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Maternal anxiety, depression and stress affects offspring gut microbiome diversity and bifidobacterial abundances

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 107, P. 253 - 264

Published: Oct. 12, 2022

Language: Английский

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The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 3, 2023

Maternal health during gestational period is undoubtedly critical in shaping optimal fetal development and future of the offspring. Gestational diabetes mellitus a metabolic disorder occurring pregnancy with an alarming increasing incidence worldwide recent years. Over years, there growing body evidence that uncontrolled maternal hyperglycaemia can potentially have detrimental effect on neurodevelopment Both human animal data linked motor cognitive impairment, as well autism spectrum disorders, attention deficit hyperactivity disorder, learning abilities psychiatric disorders. This review presents available from current literature investigating relationship between offspring neurodevelopmental impairment. Moreover, possible mechanisms accounting for effects brain like neuroinflammation, iron deficiency, epigenetic alterations, disordered lipid metabolism structural abnormalities are also highlighted. On basis demonstrated literature, it mandatory will be optimally controlled impact more thoroughly investigated.

Language: Английский

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Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The heterogeneity of ASD poses great challenges for its research and clinical translation. On the basis reviewing ASD, this review systematically summarized current status progress pathogenesis, diagnostic markers, interventions ASD. We provided an overview molecular mechanisms identified by multi‐omics studies convergent mechanism in different genetic backgrounds. comorbidities, associated with important physiological metabolic abnormalities (i.e., inflammation, immunity, oxidative stress, mitochondrial dysfunction), gut microbial were reviewed. non‐targeted omics targeting markers also Moreover, we methods behavioral educational interventions, intervention related to technological devices, on medical potential drug targets. This highlighted application high‐throughput emphasized importance seeking homogeneity from exploring convergence disease mechanisms, biomarkers, approaches, proposes that taking into account individuality commonality may be key achieve accurate diagnosis treatment

Language: Английский

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Inflammation, Anxiety, and Stress in Attention-Deficit/Hyperactivity Disorder

Biomedicines, Journal Year: 2021, Volume and Issue: 9(10), P. 1313 - 1313

Published: Sept. 24, 2021

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and serious neurodevelopmental characterized by symptoms of inattention and/or hyperactivity/impulsivity. Chronic childhood stress involved in ADHD development, highly comorbid with anxiety. Similarly, inflammatory diseases pro-inflammatory state have been associated ADHD. However, while several works studied the relationship between peripheral inflammation affective disorders such as depression or bipolar disorder, fewer explored this association In narrative review we synthetize evidence showing an interplay stress, anxiety, immune dysregulation ADHD, discuss implications potential disrupted neuroendocrine response Moreover, highlight confounding factors limitations existing studies on topic critically debate multidirectional hypotheses that either suggest inflammation, anxiety cause pathophysiology consequence disease. Untangling these relationships will diagnostic, therapeutic prognostic for patients.

Language: Английский

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A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Sept. 20, 2021

The autonomic nervous system (ANS) regulatory capacity begins before birth as the sympathetic and parasympathetic activity contributes significantly to fetus' development. Several studies have shown how vagus nerve is involved in many vital processes during fetal, perinatal postnatal life: from regulation of inflammation through anti-inflammatory cholinergic pathway, which may affect functioning each organ, production hormones bioenergetic metabolism. In addition, has been recognized primary afferent pathway capable transmitting information brain every organ body. Therefore, this hypothesis paper aims review development ANS fetal life, focusing particularly on nerve, identify possible "critical windows" that could impact its maturation. These help clinicians know when monitor fetuses effectively assess developmental status both specifically nerve. will focus factors (i.e. characteristics behaviors, maternal lifestyle pathologies, placental health dysfunction, labor, incubator conditions, drug exposure) an above-mentioned window" how. This analysis stakeholders define precise guidelines for improving management newborns, reduce potential adverse environmental impacts lead persistent long-term consequences. Since influence be reflected cardiac variability, rely particular using heart rate variability (fHRV) continued growth animal human fetuses.

Language: Английский

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