Resilience to social defeat stress in adolescent male mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2022, Volume and Issue: 119, P. 110591 - 110591

Published: June 10, 2022

Adverse social experiences during adolescence are associated with the appearance of mental illness in adulthood. Social defeat (SD) is an ethologically valid murine model to study consequences stress. In adolescent mice, SD induces depressive-like behaviors, increased anxiety and potentiates reinforcing effects cocaine alcohol. However, not all mice exposed will be susceptible these effects. Adult resilient show a consistent phenotype being behaviors increase alcohol consumption. The aim present was characterize ethanol rewarding socially defeated adolescence. To that end, were repeated SD, 24 h after last encounter, they underwent interaction test (SIT) order evaluate behaviors. Cocaine-induced reward conditioning intake evaluated two different sets 3 weeks using cocaine-induced conditioned place preference (CPP) oral self-administration (SA). neuroinflammation response measured at end experimental procedure by measuring striatal cortical levels IL-6 CX3CL1. results confirmed comparable percentage develop resilience observed adult mice. more severe Likewise, for ineffective dose consumption compared controls. CX3CL1 mainly striatum control Our confirm that, contrary prior assumptions adults, responses stress complex singular adolescents, caution should taken correct interpretation translation those phenotypes.

Language: Английский

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Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: March 3, 2022

Childhood adversity is associated with altered or dysregulated stress reactivity; these patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control responses, including subgenual anterior cingulate cortex (sgACC), paraventricular nucleus hypothalamus (PVN), bed stria terminalis (BNST) amygdala. However, relationship between childhood resting-state connectivity this network remains unclear. To end, we examined relationships threat socioeconomic deprivation, our regions interest (ROIs), affective symptom severity diagnoses. We recruited a transdiagnostic sample young adult males females ( n = 100; mean age 27.28, SD 3.99; 59 females) full distribution maltreatment history across multiple disorders. Resting-state data were acquired using 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures traumatic events abuse. Socioeconomic deprivation (SED) measure status (parental education level). Covarying for age, race sex, greater significantly lower BNST-PVN, amygdala-sgACC PVN-sgACC No significant found SED BNST-PVN number lifetime Exposure during development may entrain stress-related ways contribute responses subsequent psychopathology.

Language: Английский

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Neurochemical mechanisms of deep brain stimulation for depression in animal models

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 68, P. 11 - 26

Published: Jan. 12, 2023

Language: Английский

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On the Application of Developmental Cognitive Neuroscience in Educational Environments

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(11), P. 1501 - 1501

Published: Nov. 4, 2022

The paper overviews components of neurologic processing efficiencies to develop innovative methodologies and thinking school-based applications changes in educational leadership based on sound findings the cognitive neurosciences applied schools learners. Systems science can allow us better manage classroom-based learning instruction basis relatively easily evaluated or inefficiencies optimization instead simply examining achievement. “Medicalizing” process with concepts such as “learning disability” employing grading methods pass-fail does little aid understanding processes that learners employ acquire, integrate, remember, apply information learned. endeavors overview provided reference tools be employed a focus nervous system-based strategic approaches classroom learning.

Language: Английский

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Consequences of Inadequate Caregiving for Children’s Attachment, Neurobiological Development, and Adaptive Functioning

Clinical Child and Family Psychology Review, Journal Year: 2022, Volume and Issue: 25(1), P. 166 - 181

Published: Feb. 24, 2022

Language: Английский

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