Psychoneuroimmunology in the time of COVID-19: Why neuro-immune interactions matter for mental and physical health

Behaviour Research and Therapy, Journal Year: 2022, Volume and Issue: 154, P. 104104 - 104104

Published: May 6, 2022

The brain and immune system are intricately connected, perturbations in one have direct effects on the other. This review focuses these dynamic psychoneuroimmune interactions their implications for mental physical health context of COVID-19 pandemic. In particular, we describe how psychological states influence antiviral immunity vaccine response, changes triggered by COVID (either via infection with SARS-CoV-2 or associated stressors) can cognition, emotion, behavior. We consider negative states, which been primary focus research (and psychoneuroimmunology more generally). also positive including affect eudaimonic well-being, given increasing evidence importance as modulators immunity. finish a discussion interventions that may be effective improving function, neuro-immune axis, ultimately, health.

Language: Английский

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Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3932 - 3932

Published: April 1, 2022

Today, it is possible to investigate the biological paths and mechanisms that link mental life life. Emotions, feelings, desires, cognitions influence systems. In recent decades, psychoneuroendocrinoimmunology research has highlighted routes linking psyche-brain-immune Recently, epigenetics shown molecular by which stress states modulate information contained in genome. This shapes a new paradigm considering human being as whole, integrating biology psychology. will allow us progress towards personalized precision medicine, deeply changing medical psychological sciences clinical practice. this paper, we recognize leading on both bidirectional relations between psyche-brain-immunity consequences of states.

Language: Английский

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Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemic

Psychoneuroendocrinology, Journal Year: 2022, Volume and Issue: 143, P. 105847 - 105847

Published: June 22, 2022

Determining pre-existing biological risk markers of incident depression and other mental health sequelae after exposure to a new stressor would help identify vulnerable individuals mechanistic pathways. This study investigated primarily whether hair cortisol predicted elevated depressive symptoms in middle-aged older adults during the COVID-19 pandemic, 6 years later. A secondary aim was deduce any association differed by sex. We studied 1025 aged 50 (75% female) as part The Irish Longitudinal Study on Ageing. Hair samples were collected at 2014 (Wave 3) assessed using 8-item Center for Epidemiological Studies Depression Scale 3), 2016 4), 2018 5) again 2020 TILDA's Study. Hierarchical mixed effects logistic regression models applied investigate between levels clinically significant before pandemic. In full covariate adjusted model there interaction wave (χ2 = 8.5, p .03). Cortisol positively significantly associated with (OR =1.3, 95% CI 1.11, 1.56, .003), an increased likelihood reporting first year when compared before, OR 1.4, 1.05, 1.9, .015. There no evidence effect modification Higher cortisol, previously, among (but not before) Findings suggest phenotype which denotes susceptibility negative impact environmental stress psychological health.

Language: Английский

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The relationship of adverse childhood experiences, hair cortisol, C-reactive protein, and polygenic susceptibility with older adults’ psychological distress during the COVID-19 pandemic

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(12), P. 5038 - 5048

Published: Oct. 5, 2022

Abstract Adverse childhood experiences (ACEs) are linked to poorer mental health outcomes, and growing evidence implicates biological genetic pathways from early adversity psychopathology. However, little is known about the relationship of ACEs their underlying mechanisms with older people’s responses COVID-19 pandemic. We tested associations ACEs, hair cortisol, C-reactive protein (CRP), polygenic scores (PGS) depression, anxiety, loneliness among adults during pandemic, accounting for potential interplay risk markers. Data were drawn English Longitudinal Study Ageing, a prospective cohort study living in England. Retrospective information on collected 2006/7, while CRP cortisol measured at wave 6 (2012/13). Psychological distress was assessed before pandemic (2018–19) two assessments 2020 (June-July November-December). Associations 2050 participants using linear/logistic regression models adjusted pre-pandemic outcome measures mixed-effect assess changes The results showed that associated higher levels depression (OR = 2.55[95%CI:1.81,3.59]) anxiety 1.84[95%CI:1.13,3.01]), (b 0.28[95%CI:0.14,0.42]) Hair related an increased 1.15[95%CI:1.04,1.26]), greater 0.16[95%CI:0.03,0.30]). between psychological larger ( e.g ., OR 1.07[95%CI:1.00,1.14]). Further, individuals high experienced increases feelings compared those lower (interaction effect=0.23; 95%CI:0.1–0.37). Individuals 2+ depressive symptoms none effect=2.09; 95%CI:1.1–3.98). Higher also worse across timepoints effect=1.84;95%CI:1.41–2.41). These highlight lasting impact biosocial vulnerabilities adults’ new environmental stressors. They implicate pathophysiology later-life distress.

Language: Английский

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Polygenic predisposition, sleep duration, and depression: evidence from a prospective population-based cohort

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 20, 2023

Abstract Suboptimal sleep durations and depression frequently cooccur. Short-sleep long-sleep are commonly thought of as symptoms depression, but a growing literature suggests that they may be prodromal. While each represents process mutual influence, the directionality between them remains unclear. Using polygenic scores (PGS), we investigate prospective direction involved in suboptimal depression. Male female participants, aged ≥50, were recruited from English Longitudinal Study Ageing (ELSA). PGS for duration, short-sleep, calculated using summary statistics data UK Biobank cohort. Sleep categorised into short-sleep (“≤5 h”), optimal-sleep (“>5 to <9 (“≥9 was measured at baseline across an average 8-year follow-up. Subclinical (Centre Epidemiological Studies Depression Scale [≥4 7]) also ascertained One standard deviation increase associated with 14% higher odds onset (95% CI = 1.03–1.25, p 0.008). However, duration (OR 0.92, 95% 0.84–1.00, 0.053) 0.97, 0.89–1.06, 0.544) not during During same period, overall or long-sleep. Polygenic predisposition over period. long-sleep, suggesting different mechanisms underlie relationship subsequent older adults.

Language: Английский

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From blood to brain: Exploring the role of fibrinogen in the pathophysiology of depression and other neurological disorders

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113326 - 113326

Published: Oct. 10, 2024

Language: Английский

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The impact of the COVID-19 pandemic on cognitive decline

The Lancet Healthy Longevity, Journal Year: 2023, Volume and Issue: 4(11), P. e585 - e586

Published: Nov. 1, 2023

Language: Английский

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Dimensional emotions are represented by distinct topographical brain networks

International Journal of Clinical and Health Psychology, Journal Year: 2023, Volume and Issue: 23(4), P. 100408 - 100408

Published: Aug. 25, 2023

The ability to recognize others' facial emotions has become increasingly important after the COVID-19 pandemic, which causes stressful situations in emotion regulation. Considering importance of maintaining a social life, knowledge perceive and label oneself others requires an understanding affective dimensions, such as emotional valence arousal. However, limited information is available about whether behavioral representation dimensions similar their neural representation. To explore relationship between brain behavior representational geometries we constructed paradigm faces were categorized into geometric spaces along valence, arousal, arousal dimensions. Moreover, compared representations acquired by functional magnetic resonance imaging. We found that similarly represented brain. Specifically, less those also was dorsolateral prefrontal cortex, frontal eye fields, precuneus, early visual whereas cingulate gyrus, middle orbitofrontal fusiform cortex. In conclusion, current study suggests dimensional are presented with differential topographical organizations

Language: Английский

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Immune-neuroendocrine patterning and response to stress. A latent profile analysis in the English longitudinal study of ageing

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 600 - 608

Published: Nov. 13, 2023

Psychosocial stress exposure can disturb communication signals between the immune, nervous, and endocrine systems that are intended to maintain homeostasis. This dysregulation provoke a negative feedback loop each system has high pathological risk. Here, we explore patterns of immune-neuroendocrine activity role stress. Using data from English Longitudinal Study Ageing (ELSA), first identified latent structure (indexed by sensitivity C-reactive protein [CRP], fibrinogen [Fb], hair cortisol [cortisol], insulin growth-factor-1 [IGF-1]), within population-based cohort using profile analysis (LPA). Then, determined whether life was associated with membership different profiles. We followed 4,934 male female participants median age 65 years over four-year period (2008–2012). A three-class LPA solution offered most parsimonious fit underlying in data, 36 %, 40 24 % population belonging profiles 1 (low-risk), 2 (moderate-risk), 3 (high-risk), respectively. After adjustment for genetic predisposition, sociodemographics, lifestyle, health, higher 61 greater risk high-risk (RRR: 1.61; 95 %CI = 1.23–2.12, p 0.001), but not moderate-risk (RRR 1.10, 0.89–1.35, 0.401), as compared low-risk four later. Our findings extend existing knowledge on psychoneuroimmunological processes, revealing how inflammation neuroendocrine cluster representative sample older adults, responses time.

Language: Английский

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Risk assessment of psychiatric complications in infectious diseases: CALCulation of prognostic indices on example of COVID-19

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 15, 2024

Factors such as coronavirus neurotropism, which is associated with a massive increase in pro-inflammatory molecules and neuroglial reactivity, along experiences of intensive therapy wards, fears pandemic, social restrictions, are pointed out to contribute the occurrence neuropsychiatric conditions.

Language: Английский

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