Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population DOI Creative Commons
Qian Peng, David A. Gilder, Rebecca A. Bernert

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Abstract American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and alcohol use disorders (AUD) among all ethnic groups in US. Rates suicide AUD vary substantially between tribal across different geographical regions, underscoring a need to delineate more specific risk resilience factors. Using data from over 740 AI living within eight contiguous reservations, we assessed genetic factors for SB by investigating: (1) possible overlap with AUD, (2) impacts rare low frequency genomic variants. Suicidal included lifetime history thoughts acts, including verified deaths, scored using ranking variable phenotype (range 0–4). We identified five loci significantly associated two which are intergenic three intronic on genes AACSP1 , ANK1 FBXO11 . Nonsynonymous mutations four SERPINF1 (PEDF), ZNF30 CD34 SLC5A9 non-intronic OPRD1 HSD17B3 one lincRNA were SB. One pathway related hypoxia-inducible factor (HIF) regulation, whose 83 nonsynonymous variants 10 linked as well. Four additional genes, pathways vasopressin-regulated water metabolism cellular hexose transport, also strongly This study represents first investigation an Indian population that has high suicide. Our suggests bivariate association analysis comorbid can increase statistical power; variant high-risk enabled whole-genome sequencing potential identify novel Although such findings may be specific, functional relating PEDF HIF regulation align past reports suggest biological mechanism therapeutic target intervention.

Language: Английский

Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder DOI
Peter B. Barr, Zoë Neale,

Chris Chatzinakos

et al.

Complex Psychiatry, Journal Year: 2025, Volume and Issue: 11(1), P. 1 - 11

Published: Feb. 13, 2025

Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. Methods: We examined lifetime SA in 4,068 AUD from the Collaborative Study on Genetics Alcoholism (23% SA; 53% female; mean age: 38). explored for across other clinical conditions ascertained a interview, polygenic scores comorbid problems, and neurocognitive functioning. Results: Participants who attempted had greater trauma exposure, major depressive disorder, post-traumatic stress substance disorders (SUDs), suicidal ideation. Polygenic SA, depression, PTSD were increased odds reporting (ORs = 1.22–1.44). reported also decreased right hemispheric frontal-parietal theta interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to did not, but differences small. Conclusions: Overall, report experience levels trauma, have more severe comorbidities, carry problems. Our results demonstrate need further investigate SAs presence SUDs.

Language: Английский

Citations

2
Genetic factors associated with suicidal behaviors and alcohol use disorders in an American Indian population DOI Creative Commons
Qian Peng, David A. Gilder, Rebecca A. Bernert

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(4), P. 902 - 913

Published: Jan. 4, 2024

American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and alcohol use disorders (AUD) among all ethnic groups in US. Rates suicide AUD vary substantially between tribal across different geographical regions, underscoring a need to delineate more specific risk resilience factors. Using data from over 740 AI living within eight contiguous reservations, we assessed genetic factors for SB by investigating: (1) possible overlap with AUD, (2) impacts rare low-frequency genomic variants. Suicidal included lifetime history thoughts acts, including verified deaths, scored using ranking variable phenotype (range 0-4). We identified five loci significantly associated two which are intergenic three intronic on genes AACSP1, ANK1, FBXO11. Nonsynonymous mutations four SERPINF1 (PEDF), ZNF30, CD34, SLC5A9, non-intronic OPRD1, HSD17B3 one lincRNA were SB. One pathway related hypoxia-inducible factor (HIF) regulation, whose 83 nonsynonymous variants 10 linked as well. Four additional genes, pathways vasopressin-regulated water metabolism cellular hexose transport, also strongly This study represents first investigation an Indian population that has high suicide. Our suggests bivariate association analysis comorbid can increase statistical power; variant high-risk enabled whole-genome sequencing potential identify novel Although such findings may be specific, functional relating PEDF HIF regulation align past reports suggest biological mechanism therapeutic target intervention.

Language: Английский

Citations

6
Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders DOI Creative Commons
Hannah Raji,

Susha Dinesh,

Sameer Sharma

et al.

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2025, Volume and Issue: 61(1)

Published: Jan. 20, 2025

Abstract This abstract delves into the intricate nature of impulsivity and its ramifications across psychiatric disorders, leveraging advancements in neuroimaging psychological studies. It elucidates diverse facets impulsivity, encompassing response, choice, tendencies, emphasizing pivotal role executive functioning social development. The interplay hormonal influences, specifically cortisol, adrenaline, testosterone, is meticulously examined, unveiling associations between elevated cortisol levels, excessive adrenaline release, heightened impulsivity. ventromedial prefrontal cortex (VMPFC) assumes a central decision-making emotional regulation, demonstrating correlations with conditions, such as antisocial behavior mood disorders. Substantial contributions from neurotransmitters like dopamine serotonin to impulsive underscore imperative need for genetic neurochemical investigations identify factors crucial effective management. Interconnections stress, are accentuated, particularly Hormones, leptin ghrelin, conjunction hypothalamic–pituitary–adrenal axis, play roles conditions major depressive disorder. Concurrently, resistance exerts influence over appetite regulation. nexus substance use disorders emphasizes involvement neurobiological, neurotransmitter, components, guiding targeted interventions. Recognition gender-specific behaviors influences tailoring treatment plans. Advocating comprehensive approach that integrates assessments clinical evaluations, taking account neurobiological context, essential. While systems show promise treating aggressiveness, challenges encompass interactions, ethical considerations, limited options, necessity individualized approaches. Addressing these intricacies advancing knowledge formulating interventions Impulsive Control Disorders.

Language: Английский

Citations

0
Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review DOI

Jiaqi Wang,

Ruolei Gu,

Xiangzhen Kong

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 132, P. 110986 - 110986

Published: March 1, 2024

Language: Английский

Citations

3
Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year DOI Creative Commons

Panayotis K. Thanos,

Colin Hanna,

Abrianna Mihalkovic

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2644 - 2644

Published: Sept. 27, 2023

This study analyzed genetic risk assessments in patients undergoing bariatric surgery to serve as a predictive factor for weight loss parameters 1 year after the operation. Thirty (30) were assessed Genetic Addiction Risk Severity (GARS), which analyzes neurogenetic polymorphisms involved addiction and reward deficiency. psychosocial data collected before operation correlated with data, including changes weight, body mass index (BMI), percent of expected (%EWL). Results examined correlations between individual gene alleles, 1-year trait scores. Spearman’s revealed that OPRM1 (rs1799971) polymorphism had significant negative correlation (rs = −0.4477, p < 0.01) BMI 0.05). In addition, DRD2 allele (rs1800497) was negatively at −0.4927, 0.05), indicating one copy associated lower BMI. However, this positively both ∆Weight 0.4077, 0.05) %EWL 0.5521, post-surgery. Moreover, overall GARS score 0.4236, 0.3971, ∆BMI 0.3778, Lastly, Food Cravings Questionnaire (FCQ) scores −0.4320, post-surgery −0.4294, suggests individuals higher are more responsive treatment, especially case polymorphism. These results should translate clinically improve positivity attitude related management by those born alleles (rs1800497; rs1799971).

Language: Английский

Citations

5
Binge drinking and suicidal ideation in Peruvian adolescents: Evidence from a pooled cross-sectional survey DOI
Akram Hernández‐Vásquez, Rodrigo Vargas‐Fernández, Guido Bendezú-Quispe

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 340, P. 321 - 326

Published: Aug. 9, 2023

Language: Английский

Citations

2
Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population‐based study DOI Creative Commons
Séverine Lannoy,

Henrik Ohlsson,

Kenneth S. Kendler

et al.

Addiction, Journal Year: 2023, Volume and Issue: 119(2), P. 281 - 290

Published: Sept. 26, 2023

Abstract Background and aims Alcohol use disorder (AUD) is one of the strongest predictors suicidal behavior. Here, we measured risk suicide attempt death as a function AUD typologies. Design We used typologies from previous latent class analysis: (i) externalizing subtype (characterized by symptomatology early age onset; individuals in this group have lower education higher familial/social difficulties); (ii) described minimal psychopathology; (iii) internalizing later education). membership to predict distal outcomes (attempt death) performed regressions evaluate whether differences behavior were explained characteristics (sex, onset, number type registrations, familial/genetic for AUD, behaviors, socio‐economic indicators, marital status childhood family status). also evaluated effect prior AUD. Setting participants Based on longitudinal Swedish registry data, included 217 074 with born 1950–80. Measurements Suicide attempts identified using medical registers deaths mortality register. Findings Individuals had risks than other groups [attempt: versus psychopathology: odds ratio (OR) = 1.35, 95% confidence interval (CI) 1.35; internalizing: OR 1.47, CI 1.46, 1.48; death: 1.57, 1.58; 1.99, 1.93, 2.06]. psychopathology those (attempt: 1.09, 1.08, 1.10, 1.26, 1.23, 1.30). These at registration related sex, education, disruption Conclusions Among people Sweden, considering alcohol heterogeneity appears be meaningful way risk. The highest occurs followed subtype, then subtype.

Language: Английский

Citations

2
Risk Factors of Alcohol Use Disorders Among Inpatients with Schizophrenia: An Institutional-Based Cross-sectional Survey DOI
Bing Li, Wei Li, Jie Wang

et al.

ALPHA PSYCHIATRY, Journal Year: 2024, Volume and Issue: 25(3), P. 421 - 428

Published: Aug. 2, 2024

This study aimed to elucidate the risk factors associated with alcohol use disorders (AUDs) among inpatients schizophrenia at a specialized mental hospital in Baoding city, China. cross-sectional survey comprised 301 comorbid patients. Three binary logistic regression models were used investigate linked AUDs patients schizophrenia. Propensity score matching analysis was conducted validate inconsistent variables identified by models. Significant differences observed between and non-comorbid groups concerning sex (P < .001), disposition = .049), smoking habits place of residence .010), family relationships .002), history .008), alcoholism .003), onset latency .005), impulsivity suicide or self-injury obvious aggressive behavior .001) univariate analyses. The area under curve values for three 0.83 0.80 0.81 respectively. Binary propensity analyses indicated that introverted disposition, smoking, acute onset, impulsivity, independent an odds ratio > 1. Introverted independently Future studies should prioritize longitudinal discern evolving dynamics potential confounding factors.

Language: Английский

Citations

0
Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder DOI Creative Commons
Peter B. Barr, Zoë Neale,

Chris Chatzinakos

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 29, 2023

Abstract Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 DSM-IV dependence from the Collaborative Study on Genetics Alcoholism (23% attempt; 53% female; mean age: 38). Within participants AUD diagnosis, we explored risk across other clinical conditions, polygenic scores (PGS) for comorbid problems, neurocognitive functioning attempt. Participants who had attempted greater trauma exposure, major depressive disorder, post-traumatic stress substance disorders compared to not suicide. Polygenic attempt, depression, PTSD were reporting a attempt (ORs = 1.22 – 1.44). reported also decreased right hemispheric frontal-parietal theta interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative did not, but differences small. Overall, report appear experience levels trauma, have more severe comorbidities, carry variety problems. Our results demonstrate need further investigate presence disorders.

Language: Английский

Citations

1
Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population DOI Creative Commons
Qian Peng, David A. Gilder, Rebecca A. Bernert

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 14, 2023

ABSTRACT American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and alcohol use disorders (AUD) among all ethnic groups in US. Rates suicide AUD vary substantially between tribal across different geographical regions, underscoring a need to delineate more specific risk resilience factors. Using data from over 740 AI living within eight contiguous reservations, we assessed genetic factors for SB by investigating: (1) possible overlap with AUD, (2) impacts rare low frequency genomic variants. Suicidal included lifetime history thoughts acts, including verified deaths, scored using ranking variable phenotype (range 0-4). We identified five loci significantly associated two which are intergenic three intronic on genes AACSP1 , ANK1 FBXO11 . Nonsynonymous mutations four SERPINF1 (PEDF), ZNF30 CD34 SLC5A9 non-intronic OPRD1 HSD17B3 one lincRNA were SB. One pathway related hypoxia-inducible factor (HIF) regulation, whose 83 nonsynonymous variants 10 linked as well. Four additional genes, pathways vasopressin-regulated water metabolism cellular hexose transport, also strongly This study represents first investigation an Indian population that has high suicide. Our suggests bivariate association analysis comorbid can increase statistical power; variant high-risk enabled whole-genome sequencing potential identify novel Although such findings may be specific, functional relating PEDF HIF regulation align past reports suggest biological mechanism therapeutic target intervention.

Language: Английский

Citations

0