Depression Recognition Using Daily Wearable-Derived Physiological Data

Sensors, Journal Year: 2025, Volume and Issue: 25(2), P. 567 - 567

Published: Jan. 19, 2025

The objective identification of depression using physiological data has emerged as a significant research focus within the field psychiatry. advancement wearable measurement devices opened new avenues for individuals with in everyday-life contexts. Compared to other methods, wearables offer potential continuous, unobtrusive monitoring, which can capture subtle changes indicative depressive states. present study leverages multimodal wristband collect from fifty-eight participants clinically diagnosed during their normal daytime activities over six hours. Data collected include pulse wave, skin conductance, and triaxial acceleration. For comparison, we also utilized matched healthy controls publicly available dataset, same equivalent durations. Our aim was identify through analysis measurements derived daily life scenarios. We extracted static features such mean, variance, skewness, kurtosis indicators like heart rate, acceleration, well autoregressive coefficients these signals reflecting temporal dynamics. Utilizing Random Forest algorithm, distinguished non-depressive varying classification accuracies on aggregated 6 h, 2 30 min, 5 min segments, 90.0%, 84.7%, 80.1%, 76.0%, respectively. results demonstrate feasibility wearable-derived recognition. achieved suggest that this approach could be integrated into clinical settings early detection monitoring symptoms. Future work will explore methods personalized interventions real-time offering promising avenue enhancing mental health care integration technology.

Language: Английский

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Risk prediction models of depression in older adults with chronic diseases

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 182 - 188

Published: May 18, 2024

Detecting potential depression and identifying the critical predictors of among older adults with chronic diseases are essential for timely intervention management depression. Therefore, risk predictive models in elderly people should to be further explored. A total 3959 respondents aged 60 years or from wave four survey China Health Retired Longitudinal Study (CHARLS) were included this study. We used five machine learning (ML) algorithms three data balancing techniques construct prediction (RPMs) calculated feature importance scores determine which features The prevalence was 19.2 % Chinese survey. random forest (RF) model more accurate than other after using Synthetic Minority Oversampling Technique (SMOTE), an area under receiver operating characteristic curve (AUROC) precision-recall (AUPRC) 0.957 0.920, respectively, a balanced accuracy 0.891 sensitivity 0.875. Furthermore, we identified several important different sex patients. Further research on clinical impact study our external validation needed. After address class imbalanced problem, most RPMs achieved satisfactory predicting diseases. may thus become valuable screening tools both individuals healthcare practitioners assess

Language: Английский

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Depressive symptoms and cognitive decline in older adults

International Psychogeriatrics, Journal Year: 2024, Volume and Issue: 36(11), P. 1039 - 1050

Published: April 16, 2024

Objectives:Few studies have examined the impact of late-life depression trajectories on specific domains cognitive function. This study aims to delineate how different depressive symptom specifically affect function in older adults.Design:Prospective longitudinal cohort studySetting:Australia and United States AmericaParticipants:In total, 11,035 community-dwelling adults with a mean age 75 yearsMeasurements:Depressive were modelled from symptoms according annual Centre for Epidemiological Studies Depression Scale 10 (CES-D-10) surveys. Four identified: low ("nondepressed"), consistently mild ("subthreshold depression"), moderate ("persistent initially but increasing ("emerging depression"). Global cognition (Modified Mini-Mental State Examination [3MS]), verbal fluency (Controlled Oral Word Association Test [COWAT]), processing speed (Symbol Digit Modalities [SDMT]), episodic memory (Hopkins Verbal Learning – Revised [HVLT-R]), composite z-score assessed over subsequent median 2 years.Results:Subthreshold predicted impaired performance SDMT (Cohen's d −0.04) score (−0.03); emerging (−0.13), HVLT-R (−0.09), 3 MS (−0.08) (−0.09); persistent (−0.08), (−0.11), (−0.09).Conclusions:Depressive are associated later speed. These effects small. Diverse impacts

Language: Английский

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20‐year depressive symptoms, dementia, and structural neuropathology in older women

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3472 - 3484

Published: April 9, 2024

The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.

Language: Английский

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Prevalensi Problem Depresi pada Pasien Diabetes Mellitus di Puskesmas

Jurnal Ilmiah Farmasi (Scientific Journal of Pharmacy), Journal Year: 2025, Volume and Issue: 20(2), P. 194 - 206

Published: Jan. 2, 2025

Latar belakang: Gangguan depresi berpotensi menyebabkan ketidakpatuhan terapi dan komplikasi pada pasien Diabetes Mellitus (DM). Masih terdapat hasil yang inkonsisten terkait prevalensi faktor risiko DM. Tujuan: Penelitian ini bertujuan untuk menentukan DM dengan gejala menganalisis faktor-faktor berhubungan depresi. Metode: merupakan studi observasional cross-sectional melibatkan dewasa penderita di beberapa puskesmas Yogyakarta disampling metode purposive sampling. Karakteristik subyek diperoleh wawancara. Kuesioner PHQ-9 digunakan menilai Hubungan antara karakteristik dianalisis Chi-square atau Fisher’s exact test menggunakan SPSS versi 23. Hasil: Dari total 268 subyek, sebagian besarnya adalah perempuan berusia 40-60 tahun. Lebih dari separuh menderita < 5 Sebagian besar memiliki minimal 1 penyakit penyerta kombinasi antidiabetika oral. Prevalensi penelitian 36,6%. Faktor tingkat pendidikan rendah (p=0,026), menjadi tulang punggung keluarga (p=0,000) selama 5-10 tahun (p=0,027). Kesimpulan: Pasien karakter tertentu lebih rentan mengalami dibandingkan lain sehingga perlu mendapat perhatian khusus tenaga kesehatan agar tujuan tercapai.

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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 67 - 67

Published: Jan. 5, 2025

Post-translational modifications of proteins via palmitoylation, a thioester linkage 16-carbon fatty acid to cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing function. Little is known about how altered palmitoylation affects function at the systemic level and contributes CNS pathology. However, recent studies suggested role downregulation palmitoyl acetyltransferase (DHHC) 21 gene expression development Major Depressive Disorder (MDD)-like syndrome. Here, we sought investigate susceptibility (sucrose preference below 65%) or resilience > stress-induced anhedonia DHHC hippocampus C57BL/6J mice during phase spontaneous recovery from anhedonia. Because MDD recurrent disorder, it important understand molecular mechanisms underlying not only symptomatic disease but also state temporary remission. Indeed, changes associated with application pharmacotherapy remission stage are currently well understood. Therefore, used mouse model chronic stress address these questions. The protocol consisted rat exposure, social defeat, restraint stress, tail suspension. Mice group were treated, received imipramine drinking water (7 mg/kg/day), intraperitoneal injections dicholine succinate (DS; 25 mg/kg/day) starting 7 days prior continuing 14-day procedure. Controls either untreated treated two drugs. At 1st after-stress week, sucrose preference, forced swim, novel cage, fear-conditioning tests carried out; test 5-day Morris maze followed by sacrifice on post-stress day 31 all performed. Transcriptome Illumina analysis hippocampi was out. Using RT-PCR, hippocampal Dhhc3, Dhhc7, Dhhc8, Dhhc13, Dhhc14, Dhhc21 studied. We found that lowered subgroup exhibited prolonged floating behavior, behavioral invigoration, impaired contextual fear conditioning, while auditory conditioning unaltered. phase, no found, acquisition unchanged groups. In anhedonic, resilient animals, Dhhc8 lowered, Dhhc14 increased. Antidepressant treatment drug partially preserved abnormalities. Our data suggest likely be implicated depression stage, serving as targets preventive therapy.

Language: Английский

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Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment

Psychological Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 8, 2025

Abstract Background: Late-life depression (LLD) is characterized by repeated recurrent depressive episodes even with maintenance treatment. It unclear what clinical and cognitive phenotypic characteristics present during remission predict future recurrence. Methods: Participants (135 remitted LLD 69 comparison subjects across three institutions) completed baseline phenotyping, including psychiatric, medical, social history, psychiatric symptom personality trait assessment, neuropsychological testing. were clinically assessed every two months for years while receiving standard antidepressant Analyses examined group differences in measure using general linear models. Concurrent associations between measures diagnostic groups LASSO logistic regression. Results: Sixty (44%) participants experienced a relapse over the two-year period. Numerous all domains differed participants. Only residual severity, rumination, medical comorbidity, executive dysfunction significantly predicted classification. Fewer relapsing sustained subgroups, exhibiting greater treatment intensity, fatigue, disability, higher systolic blood pressure, life stress lower instrumental support. Relapsing classification was informed support, stress. Conclusions: A wide range of factors groups. less support informing vulnerability to subsequent relapse. This research suggests potential targets prevention emphasizes need translatable biomarkers inform care.

Language: Английский

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Adherence to the 24-hour movement behavior guidelines and depression risk among older adults from the United States

Journal of Activity Sedentary and Sleep Behaviors, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 9, 2025

Abstract Background While recent studies, primarily among Asian cohorts, have linked adherence to 24-hour movement behavior (24-HMB) guidelines with improved mental health—some of which show sex differences—few studies explored these relationships older adults from the United States. Methods National Health and Nutrition Examination Survey data 2011-2018 were examined in 2,812 (≥ 65years). Those considered adherent 24-HMB had a sleep duration 7–8 h./night, moderate-vigorous physical activity (MVPA) ≥ 150 min/wk., sedentary (SB) < 8 h./day. Sleep duration, SB, MVPA self-reported, SB obtained validated Global Physical Activity Questionnaire. Depression was measured using Patient Questionnaire (PHQ-9), score 10 indicating depression. Logistic regression used evaluate overall sex-stratified associations between non-adherence all three behaviors, combinations two or individual guidelines, odds depression, adjusted for putative confounders. Results Among full sample, associated 1.7 [95% confidence interval (CI):1.1, 3.1; p = 0.02] higher depression versus those that adhered behaviors. After stratification, association only persisted males [OR 2.5 (95% CI:1.1, 5.4); 0.02]. Within observed who did not adhere + guidelines. Sex-stratified findings revealed remained significant males. sample adults, guideline 2.1 CI:1.4, 3.3; 0.001) compared guideline. Conclusions provide evidence specifically males, suggesting potential sex-specific effect warrants further investigation. Future longitudinal designs are needed confirm explore mechanisms underlying associations.

Language: Английский

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Rural Communities in the Deep South: Examining the Relationship Between Social Function and General Health Perceptions in Older Black Americans

Journal of Racial and Ethnic Health Disparities, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

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Postpartum depression in relation to chronic diseases and multimorbidity in women’s mid-late life: a prospective cohort study of UK Biobank

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

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