Evolutionary neurogenomics: Lengthy resolutions for complex brains
Current Biology,
Journal Year:
2024,
Volume and Issue:
34(8), P. R315 - R318
Published: April 1, 2024
Language: Английский
Decreased Brain Serotonin in rbfox1 Mutant Zebrafish and Partial Reversion of Behavioural Alterations by the SSRI Fluoxetine
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(2), P. 254 - 254
Published: Feb. 16, 2024
RBFOX1
functions
as
a
master
regulator
of
thousands
genes,
exerting
pleiotropic
effect
on
numerous
neurodevelopmental
and
psychiatric
disorders.
A
potential
mechanism
by
which
may
impact
these
disorders
is
through
its
modulation
serotonergic
neurotransmission,
common
target
for
pharmacological
intervention
in
conditions
linked
to
RBFOX1.
However,
the
precise
effects
system
remain
largely
unexplored.
Here
we
show
that
homozygous
rbfox1sa15940
zebrafish,
express
shorter,
aberrant
rbfox1
mRNA,
have
significantly
reduced
serotonin
levels
telencephalon
diencephalon.
We
observed
acute
administration
fluoxetine
partially
reverses
associated
behavioural
alterations.
The
hyperactive
phenotype
altered
shoaling
behaviour
rbfox1sa15940/sa15940
zebrafish
could
be
reversed
with
exposure
Open
Field
Shoaling
test,
respectively.
other
paradigms,
hyperactivity
was
not
diminished,
suggesting
distinct
intrinsic
motivation
locomotion
different
paradigms.
Acute
did
reverse
alterations
aggression
social
novelty
tests,
involvement
neurological
mechanisms
behaviours.
These
findings
underscore
importance
investigating
intricate
working
gain
better
understanding
along
their
treatment.
Language: Английский
Identification of gene co-expression modules from zebrafish brain data: Applications in psychiatry illustrated through alcohol-related traits
Laila Al‐Soufi,
No information about this author
Álvaro J. Arana,
No information about this author
Fernando Facal
No information about this author
et al.
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
135, P. 111136 - 111136
Published: Sept. 3, 2024
Language: Английский
rbfox1loss of function in zebrafish leads to dysregulation inbdnf/trkb2andpac1aexpression resulting in HPI axis hyperactivation, altered stress response and allostatic overload
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
ABSTRACT
RBFOX1
regulates
transcriptional
networks
linked
to
synaptic
transmission
and
neurodevelopment.
Mutations
in
the
gene
are
associated
with
psychiatric
disorders
but
how
influences
disorder
vulnerability
remains
unclear.
Recent
studies
showed
that
mediates
alternative
splicing
of
PAC1
,
a
critical
HPA
axis
activator.
Further,
dysfunction
is
dysregulation
BDNF/TrkB,
pathway
promoting
neuroplasticity,
neuronal
survival,
stress
resilience.
Hence,
may
increase
via
dysregulation,
leading
disrupted
development
allostatic
overload.
To
test
this
hypothesis,
we
generated
zebrafish
rbfox1
loss
function
(LoF)
line
examined
behavioural
molecular
effects
during
development.
In
larvae
adults,
LoF
resulted
hyperactivity,
impulsivity
hyperarousal,
alterations
proliferation,
fertility
traits
larvae,
expression
pac1a,
bdnf,
trkb2
HPI
genes.
These
latter
were
restored
after
chronic
TrkB
agonist/antagonist
treatment.
bdnf
/
axes
was
only
seen
following
acute
stress.
Our
findings
revealed
strict
interplay
between
BDNF/TrkB
resilience
suggest
predisposes
diseases
through
hyperactivation
development,
impairing
adaptation
heightening
Language: Английский