Structural neural plasticity evoked by rapid-acting antidepressant interventions
Clara Liao,
No information about this author
Alisha N. Dua,
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Cassandra Wojtasiewicz
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et al.
Nature reviews. Neuroscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Language: Английский
Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies
Baoru Zhao,
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Zhihan Liu,
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Youze He
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et al.
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 3, 2025
Structural
neuroimaging
findings
in
Subthreshold
depression
(StD)
patients
at
different
ages
are
highly
heterogeneous.
This
study
aims
to
investigate
the
pathophysiology
of
StD
across
ages.
Literature
searches
for
MRI
studies
were
conducted
11
databases,
including
PubMed
and
Embase,
from
database
inception
June
18,
2024.
An
activation
likelihood
estimation
(ALE)
meta-analysis
was
performed
on
A
total
24
included.
The
results
revealed
that
significant
convergent
brain
regions
primarily
located
within
frontostriatal
circuit.
Age-related
differences
observed.
For
adolescent
patients,
caudate,
putamen,
anterior
cingulate
cortex
(ACC),
medial
frontal
gyrus
(MFG).
young
adult
inferior
gyrus,
parahippocampal
insula,
claustrum,
globus
pallidus.
middle-aged
older
ACC,
MFG,
superior
gyrus.
abnormalities
circuit
features
common
Additionally,
unique
identified
between
age
groups.
These
elucidated
mechanisms
provided
a
theoretical
basis
its
prevention
treatment.
Language: Английский
Are resting-state network alterations in late-life depression related to synaptic density? Findings of a combined 11C-UCB-J PET and fMRI study
Cerebral Cortex,
Journal Year:
2025,
Volume and Issue:
35(3)
Published: March 1, 2025
Abstract
This
study
investigates
the
relationship
between
resting-state
functional
magnetic
resonance
imaging
(rs-fMRI)
topological
properties
and
synaptic
vesicle
glycoprotein
2A
(SV2A)
positron
emission
tomography
(PET)
density
(SD)
in
late-life
depression
(LLD).
18
LLD
patients
33
healthy
controls
underwent
rs-fMRI,
3D
T1-weighted
MRI,
11C-UCB-J
PET
scans
to
assess
SD.
The
rs-fMRI
data
were
utilized
construct
weighted
networks
for
calculating
four
global
metrics,
including
clustering
coefficient,
characteristic
path
length,
efficiency,
small-worldness,
six
nodal
degree,
strength,
local
betweenness
centrality.
provided
standardized
uptake
value
ratios
as
SD
measures.
exhibited
preserved
organization,
with
reduced
regions
associated
LLD,
such
medial
prefrontal
cortex
(mPFC),
increased
basal
ganglia
cerebellar
regions.
Notably,
a
negative
correlation
was
observed
centrality
mPFC
depressive
symptom
severity.
No
significant
alterations
or
associations
found,
challenging
hypothesis
that
are
molecular
basis
changes
LLD.
Our
findings
suggest
other
mechanisms
may
underlie
connectivity
these
patients.
Language: Английский
Insights From the Postmortem Transcriptome of a Geriatric Population With Depressive Symptoms
Biological Psychiatry Global Open Science,
Journal Year:
2025,
Volume and Issue:
5(3), P. 100493 - 100493
Published: May 1, 2025
Language: Английский
Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Neuropsychopharmacology,
Journal Year:
2024,
Volume and Issue:
50(1), P. 153 - 163
Published: July 22, 2024
Language: Английский
The association between ‘weekend warrior’, regular exercise, and cognitive function in elderly individuals with and without depressive symptoms: A cross-sectional analysis from NHANES 2011–2014
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
367, P. 1 - 7
Published: Sept. 1, 2024
Language: Английский