Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma DOI Creative Commons
Huancheng Zeng,

Qiongzhi Jiang,

Rendong Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

Abstract Melanoma is a highly malignant form of skin cancer that typically originates from abnormal melanocytes. Despite significant advances in treating metastatic melanoma with immune checkpoint blockade (ICB) therapy, substantial number patients do not respond to this treatment and face risks recurrence metastasis. This study collected data multiple datasets, including cohorts Riaz et al., Gide MGH, Abril-Rodriguez focusing on on-treatment samples during ICB therapy. We used the single-sample gene set enrichment analysis (ssGSEA) method calculate immunogenic cell death scores (ICDS) employed an elastic network algorithm construct model predicting efficacy. By analyzing 18 ICD signatures, we identified 9 key signatures effectively predict response for specimens. Results showed high had significantly higher rates therapy compared those low scores. ROC demonstrated AUC values both training validation sets were around 0.8, indicating good predictive performance. Additionally, survival revealed longer progression-free (PFS) overall (OS). identify related melanoma. These features can only efficacy but also provide references clinical decision-making. The results indicate plays important role immunotherapy expressing more accurately prognosis specimens, thus providing basis personalized treatment.

Language: Английский

Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment DOI
Zhenhu Guo, Xiaohan Gao, Jingsong Lu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6975 - 6989

Published: Feb. 20, 2024

Regarded as one of the hallmarks tumorigenesis and tumor progression, evasion apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid apoptosis by synchronously inducing paraptosis together with was successfully designed fabricated breast treatment. brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were via gas diffusion method. Further on, Cu2+-tannic acid metal phenolic network embedded onto NPs surface self-assembling, followed mDSPE-PEG/lipid capping form DSF-loaded dual-ions trap". The as-prepared nanotrap undergo acid-triggered biodegradation upon being endocytosed cells within lysosome Ca2+, Cu2+, DSF releasing simultaneously. released Ca2+ could cause mitochondrial overload lead hydrogen peroxide (H2O2) overexpression. Meanwhile, Ca2+/reactive oxygen species-associated dysfunction death. Most importantly, be further induced strengthened toxic dithiocarbamate (DTC)–copper complexes formed Cu2+ combined DTC, metabolic products DSF. Additionally, will reduced intracellular glutathione generate Cu+, which can catalyze H2O2 produce hydroxyl radical Cu+-mediated Fenton-like reaction apoptosis. Both in vitro cellular assays vivo antitumor evaluations confirmed therapeutic efficiency dual ion nano trap. This study broaden cognition scope dual-ion-mediated multifunctional nanoplatform.

Language: Английский

Citations

27
The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway DOI Open Access
Vasiliki Zoi, Athanassios P. Kyritsis, Vasiliki Galani

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1554 - 1554

Published: April 18, 2024

Cancer is a life-threatening disease and one of the leading causes death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures been investigated for their multimodal properties. Curcumin polyphenol isolated from rhizomes Curcuma longa has widely studied its anti-inflammatory, anti-oxidant, effects. acts on regulation different aspects cancer development, including initiation, metastasis, angiogenesis, progression. The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway key target therapy, since it implicated proliferation, cell survival. found to inhibit PI3K/Akt tumor cells, primarily via mediators, growth factors, protein kinases, cytokines. This review presents potential curcumin malignancies, such as glioblastoma, prostate breast cancer, head neck cancers, through targeting signaling pathway.

Language: Английский

Citations

27
Cannabidiol induces ERK activation and ROS production to promote autophagy and ferroptosis in glioblastoma cells DOI
Na Young Kim,

Siddegowda Gopalapura Shivanne Gowda,

Seok‐Geun Lee

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 110995 - 110995

Published: April 5, 2024

Language: Английский

Citations

13
Targeting paraptosis in cancer: opportunities and challenges DOI Open Access
Fangquan Chen, Hu Tang,

Xiutao Cai

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(3), P. 349 - 363

Published: Jan. 4, 2024

Language: Английский

Citations

12
Blood–Brain Barrier-Penetrative Fluorescent Anticancer Agents Triggering Paraptosis and Ferroptosis for Glioblastoma Therapy DOI
Jiefei Wang,

Mingyue Cao,

Lulu Han

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(42), P. 28783 - 28794

Published: Oct. 11, 2024

Currently used drugs for glioblastoma (GBM) treatments are ineffective, primarily due to the significant challenges posed by strong drug resistance, poor blood-brain barrier (BBB) permeability, and lack of tumor specificity. Here, we report two cationic fluorescent anticancer agents (TriPEX-ClO

Language: Английский

Citations

12
Zearalenone Induces Blood-Testis Barrier Damage through Endoplasmic Reticulum Stress-Mediated Paraptosis of Sertoli Cells in Goats DOI Open Access
Tengfei Liu, Gengchen Liu,

Y. Wen Xu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 553 - 553

Published: Dec. 31, 2023

Zearalenone (ZEA) is present worldwide as a serious contaminant of food and feed causes male reproductive toxicity. The implication paraptosis, which nonclassical paradigm cell death, unclear in ZEA-induced disorders. In this study, the toxic effects ZEA on blood-testis barrier (BTB) related mechanisms paraptosis were detected goats. exposure, vivo, caused significant decrease spermatozoon quality, destruction seminiferous tubules, damage to BTB integrity. Furthermore, exposure Sertoli cells (SCs) vitro showed similar dysfunction structure function. Importantly, formation massive cytoplasmic vacuoles ZEA-treated SCs corresponded highly swollen dilative endoplasmic reticulum (ER), inhibition significantly alleviated SC death vacuolization, indicated important contribution damage. Meanwhile, expression ER stress marker proteins was increased after treatment but decreased under paraptosis. vacuole induced by ZEA, remarkably blocked inhibition. conclusion, these results facilitate exploration involved

Language: Английский

Citations

15
Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands DOI Creative Commons
Ricardo G. Teixeira, Alessia Stefanelli, Adhan Pilon

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6081 - 6098

Published: Feb. 24, 2024

In this work, we investigated the anticancer activity of several novel silver(I) 2,2′-bipyridine complexes containing either triphenylphosphane (PPh3) or 1,2-bis(diphenylphosphino)ethane (dppe) ligands. All compounds were characterized by diverse analytical methods including ESI-MS spectrometry; NMR, UV–vis, and FTIR spectroscopies; elemental analysis. Moreover, also studied X-ray single-crystal diffraction. Subsequently, for their against drug-resistant -sensitive cancer cells. Noteworthily, neither carboplatin oxaliplatin resistance nor p53 deletion impacted on efficacy. MES-OV cells displayed exceptional hypersensitivity to dppe-containing drugs. This effect was not based thioredoxin reductase inhibition, enhanced drug uptake, apoptosis induction. contrast, dppe silver drugs induced paraptosis, a recently described form programmed cell death. Together with good tumor specificity compound's class, work suggests that could be interesting candidates treatment resistant ovarian cancer.

Language: Английский

Citations

5
Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer DOI
Wen-Yu Lyu,

Jun Cao,

Wei-Qing Deng

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 141, P. 156647 - 156647

Published: March 15, 2025

Language: Английский

Citations

0
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells DOI
So Young Kim, Yung Hyun Choi

Toxicological Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Language: Английский

Citations

0
APEX1 attenuates ERS-induced paraptosis by inhibiting the P53 pathway in LECs DOI

Renhao Zhong,

Lihua Kang, Wenjing Geng

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110393 - 110393

Published: April 1, 2025

Language: Английский

Citations

0