Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 7, 2025

Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role development atherosclerosis. Key metabolites and enzymes sphingolipid metabolism influence pathogenesis atherosclerosis variety ways, including inflammatory responses oxidative stress. Thus, investigation metabolism-related key may provide novel insights treatment targets for This review discusses various mechanisms research progress on relationship between metabolites, related enzymes, Finally, we look into future direction phytosphingolipids.

Language: Английский

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Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

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Electric double layer and thermal radiation effects on micropolar blood particles conveying Cu-MoS2-CuO nanoparticles in squeezed arterial channel

Nuclear Engineering and Technology, Journal Year: 2025, Volume and Issue: 57(8), P. 103604 - 103604

Published: April 5, 2025

Language: Английский

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Advanced computational modeling of Darcy-Forchheimer effects and nanoparticle-enhanced blood flow in stenosed arteries

Engineering Applications of Artificial Intelligence, Journal Year: 2025, Volume and Issue: 152, P. 110737 - 110737

Published: April 8, 2025

Language: Английский

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Mercury-Mediated Cardiovascular Toxicity: Mechanisms and Remedies

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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Nonlinear Coupled Equations Free-Boundary Problem in Atherosclerosis: Symmetry Analysis of Solutions and Numerical Simulation

Symmetry, Journal Year: 2025, Volume and Issue: 17(2), P. 244 - 244

Published: Feb. 6, 2025

Atherosclerosis, a chronic inflammatory cardiovascular disease closely related to plaque formation during arteriosclerosis, poses significant threat global health. To deepen the understanding of multifaceted interactions driving atherosclerosis progression and provide theoretical support for designing targeted therapeutic strategies, this study establishes nonlinear coupled atherosclerotic free-boundary model integrating immune cells, cytokines, oxidized low-density lipoprotein. By applying compression mapping principle, local existence uniqueness solutions are proven, while revealing certain symmetries in model’s solution structure. Under specific assumptions, quasi-steady-state approximate is derived, its demonstrated. Through numerical simulations using finite difference method, temporal spatial evolution pro-inflammatory macrophages lipoprotein analyzed. The findings highlight strength capturing intricate dynamics atherosclerosis, uncovering underlying mechanisms identifying targets. evaluating across types stenosis levels, experimental design further validated ability replicate clinical processes reinforced predictive accuracy. Notably, process analysis solution, equations boundary conditions play crucial role determining properties. However, current one-dimensional has limitations. Future research should focus on developing higher-dimensional models more influencing factors enhance applicability complex disease.

Language: Английский

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Phenolic Compounds: Investigating Their Anti-Carbonic Anhydrase, Anti-Cholinesterase, Anticancer, Anticholinergic, and Antiepileptic Properties Through Molecular Docking, MM-GBSA, and Dynamics Analyses

Korean Journal of Chemical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract Phenolic compounds are a new class of Carbonic Anhydrase inhibitors (CAIs). Despite numerous advancements in treatment approaches, cancer continues to be growing health problem worldwide. In our study, we tested the effects 4-hydroxy-3-methoxyacetophenone (1) , doxycycline hydrochloride (2) 5,7-dichloro-8-hydroxyquinoline (3) methyl 3,4,5-trihydroxybenzoate (4) 2-hydroxy-4-methylacetophenone (5) 6-hydroxy-4-methylcoumarin (6) and 2,5-dihydroxyacetophenone (7) on Achetylcholynesterase (AChE), Butrycholynesterase (BChE), Human anhydrase I (hCA I) enzymes. The U2OS human osteosarcoma cell line was used determine anticancer potential these phenolic compounds. proliferation colony formation were analyzed using Neutral Red Uptake (NRU) assay clonogenic assay. K i values arachidonoyl dopamine, 2,4,6-trihydroxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzoic acid 203.80, 1170.00, 910.00 mM, respectively, for hCA I, 75.25, 354.00, 1510.00 II II). Additionally, IC 50 from vivo studies found range 173.25 1360.00 mM CA II, CO 2 -hydratase activity methods. NRU results revealed that had dose-dependent cytotoxic effect cells. cells determined > 100, 93.7, 81.4, 26.9, 53.1, 100 µM, respectively. Notably, compound with lowest value, significantly suppressed at 5 10 µM concentrations. These demonstrated could inhibit approximately 30% CO2-hydratase total enzyme rat erythrocytes. Furthermore, suggests molecules pave way development approaches treatment. activities seven studied compared against AChE (PDB ID: 4M0E), BChE 5NN0), 2CAB), E3 ubiquitin-protein ligase 4HG7) proteins. binding free energy molecule highest docking score is computed MM/GBSA techniques. Finally, molecular dynamics simulations performed between 4M0E protein over 0–200 ns interval. Graphical abstract

Language: Английский

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Effects of Exercise Body Conditions on Hemodynamics of Blood Flow in Saccular ICA Aneurysms: Pre- and Post-Stent-Induced Deformation

Chinese Journal of Physics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background Atherosclerosis is a widely studied pathophysiological foundation of cardiovascular diseases. Inflammation and dyslipidemia are risk factors that promote the formation atherosclerotic plaques. The gut microbiota their metabolites considered independent for atherosclerosis. Polydatin combined with hawthorn flavonoids, as extracts Polygonum cuspidatum Sieb. et Zucc . Crataegus pinnatifida Bunge , have shown excellent protective effects. However, underlying mechanism requires further investigation. Our study aimed to explore anti-atherosclerotic through metabolites. Methods ApoE −/− mice were fed either normal-chow diet or high-fat diet. polydatin flavonoids group received varied doses flavonoids: high dose (polydatin 200 mg/kg daily; 100 daily), medium 50 low 25 daily). control model groups administered distilled water (0.2 mL experiment lasted 24 weeks. Results administration significantly reduced lipid inflammatory cytokine levels, meanwhile, lesions in diet-induced decreased. Additionally, also inhibited enhancement trimethylamine N-oxide (TMAO), (TMA) levels HFD-induced by regulating expression hepatic flavin-containing enzyme monooxygenase 3 (FMO3). 16S rRNA sequencing results demonstrated high-dose treatment increased abundance Actinobacteriota Atopobiaceae Coriobacteriaea_UCG-002 decreased Desulfobacterota Norank_f_Muribaculaceae was enriched medium-dose simvastatin groups, Lactobacillus mainly low-dose groups. According metagenetic results, functional annotations suggested biological processes each focused on metabolism-related processes. Specifically, may regulate TMA-producing bacteria (Coriobacteriaceae, Desulfovibrio Muribaculum Clostridium ) related enzymes glycolipid metabolic pathways exert an important effect prevention Conclusion could glucolipid pathway, attenuate reduce plaques remodeling microbiota.

Language: Английский

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The effect of vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177491 - 177491

Published: March 1, 2025

Language: Английский

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