γδ T cells: origin and fate, subsets, diseases and immunotherapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Language: Английский

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Acute lymphoblastic leukaemia

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 13, 2024

Language: Английский

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5-Hydroxymethylcytosine modifications in circulating cell-free DNA: frontiers of cancer detection, monitoring, and prognostic evaluation

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 7, 2025

Abstract Developing accurate, clinically convenient, and non-invasive methods for early cancer detection, monitoring, prognosis assessment is essential improving patient survival rates, enhancing quality of life, reducing the socioeconomic burden associated with cancer. This goal critical in precision oncology. Genetic epigenetic alterations circulating cell-free DNA (cfDNA) have emerged as transformative tools advancing outcomes. Among these, 5-hydroxymethylcytosine (5hmC) modifications cfDNA stand out promising markers, offering insights into initiation, progression, metastasis, across various types, such lung cancer, colorectal hepatocellular carcinoma. review comprehensively explores biology sequencing methodologies 5hmC, emphasizing their potential screening, diagnosis, treatment prognostic assessment. It highlights recent advancements cfDNA-derived 5hmC signatures’ applications, addressing strengths limitations context clinical translation. Furthermore, this outlines key challenges future directions integrating routine practice, facilitating personalized management.

Language: Английский

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Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 132 - 132

Published: Dec. 30, 2023

Dietary risk has always been a major factor for colorectal cancer (CRC). However, the contribution of dietary factors to CRC at level region, gender, and age not fully characterized. Based on Global Burden Disease (GBD) 2019 study, death rates, age-standardized mortality rates (ASDRs), estimated annual percentage changes (EAPCs) were calculated assess trends attributable over past 30 years. Globally, cases increased 1,085,797 in 2019, number deaths attributed 365,752 representing approximately one-third all CRC-related fatalities. Overall, ASDR risks was 4.61 per 100,000 with slight downward trend (EAPC = -0.29). Notably, there is rising early-onset associated factors. To alleviate burdens, it recommended elevate intake whole grains, milk, calcium, fiber while reducing consumption red processed meats. The results will improve understanding, provide guidance diet different regions, groups worldwide.

Language: Английский

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AML treatment: conventional chemotherapy and emerging novel agents

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 430 - 448

Published: April 20, 2024

Language: Английский

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Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 167, P. 112819 - 112819

Published: July 6, 2024

Language: Английский

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Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 318 - 318

Published: Jan. 20, 2025

Algae are a rich source of bioactive compounds that have wide range beneficial effects on human health and can show significant potential in the treatment hematological malignancies such as leukemia, lymphoma, multiple myeloma. These diseases often pose therapeutic challenge despite recent advances (e.g., use immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, targeted therapy). A considerable number patients experience relapses or resistance to applied therapies. Algal compounds, alone combination with chemotherapy other more advanced therapies, exhibited antitumor preclinical studies may improve disease outcomes. include ability induce apoptosis, inhibit tumor growth, immune responses. However, most these conducted vitro, without vivo validation clinical trials. This paper summarizes current evidence vitro algae extracts isolated myeloma lines. In addition, we address application algae-derived drug carriers their synergistic against hematologic malignancies.

Language: Английский

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Association of muscle strength and cardiorespiratory fitness with all-cause and cancer-specific mortality in patients diagnosed with cancer: a systematic review with meta-analysis

British Journal of Sports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. bjsports - 108671

Published: Jan. 21, 2025

Objectives To examine the association between muscle strength and cardiorespiratory fitness (CRF) with all-cause cancer-specific mortality in patients diagnosed cancer, whether these associations are affected by type and/or stage of cancer. Method A systematic review meta-analysis was carried out. Five bibliographic databases were searched to August 2023. Results Forty-two studies included (n=46 694). Overall, cancer high or CRF levels (when dichotomised as vs low) had a significant reduction risk 31–46% compared those low physical levels. Similarly, 11% found for change per unit increments strength. In addition, associated an 8–46% reduced advanced stages, 19–41% observed lung digestive cancers. Lastly, 18% mortality. Conclusion High significantly lower increases These components especially predictive stages well This highlights importance assessing measures predicting patients. Given findings, tailored exercise prescriptions improve may contribute reducing cancer-related

Language: Английский

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Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 27, 2025

Background Multiple myeloma (MM) is a growing global public health challenge. Known epidemiological data suggest that MM accounts for approximately 10% of all hematologic malignancies and remains the second most common cancer worldwide. This study utilized from 2021 Global Burden Diseases (GBD) to evaluate prevalence, incidence, mortality, disability-adjusted life years (DALYs), attributable risk factors 1990 2021, project future trends next 15 years. Methods GBD were analyzed assess MM’s burden using four key measures: DALYs. Estimates are reported per 100,000 population with uncertainty intervals (UI). Temporal assessed through estimated annual percentage change (EAPC) 95% confidence (CI). All analyses conducted R version 4.2.1. Results From DALYs more than doubled, particularly among males. Social-Demographic Index (SDI) regions showed increases in ASPR, ASIR, ASMR, ASDR (all EAPCs >0), middle SDI exhibiting rapid growth. ARIMA model predictions will continue rising over The proportion cases high BMI also increased globally, 6.40% 7.96% 2021. primarily affects older adults, highest incidence observed 70–74 age group mortality rate recorded same range. Conclusion presents an escalating Targeted preventive interventions improvements diagnosis, treatment, care critical, especially underdeveloped regions, address MM.

Language: Английский

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Checkpoint Inhibition Prior to Stem Cell Transplantation Increases the Risk of Inflammatory Adverse Events

Targeted Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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