Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 3, 2023
Abstract
Osteoarthritis
(OA)
is
a
chronic
degenerative
joint
disorder
that
leads
to
disability
and
affects
more
than
500
million
population
worldwide.
OA
was
believed
be
caused
by
the
wearing
tearing
of
articular
cartilage,
but
it
now
commonly
referred
as
whole-joint
initiated
with
biochemical
cellular
alterations
in
synovial
tissues,
which
histological
structural
changes
ends
up
whole
tissue
dysfunction.
Currently,
there
no
cure
for
OA,
partly
due
lack
comprehensive
understanding
pathological
mechanism
initiation
progression
disease.
Therefore,
better
signaling
pathways
key
molecules
involved
pathogenesis
crucial
therapeutic
target
design
drug
development.
In
this
review,
we
first
summarize
epidemiology
including
its
prevalence,
incidence
burdens,
risk
factors.
We
then
focus
on
roles
regulation
pathways,
such
Wnt/β-catenin,
NF-κB,
focal
adhesion,
HIFs,
TGFβ/ΒΜP
FGF
regulators
AMPK,
mTOR,
RUNX2
onset
development
OA.
addition,
factors
associated
MMPs,
ADAMTS/ADAMs,
PRG4,
are
discussed
detail.
Finally,
provide
updates
current
clinical
therapies
trials
biological
treatments
drugs
Research
advances
basic
knowledge
cartilage
biology
will
have
significant
impact
translational
value
developing
strategies.
Bone Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Feb. 29, 2024
Abstract
Diabetic
osteoporosis
(DOP)
is
a
significant
complication
that
poses
continuous
threat
to
the
bone
health
of
patients
with
diabetes;
however,
currently,
there
are
no
effective
treatment
strategies.
In
diabetes,
increased
levels
ferroptosis
affect
osteogenic
commitment
and
differentiation
mesenchymal
stem
cells
(BMSCs),
leading
skeletal
changes.
To
address
this
issue,
we
aimed
target
propose
novel
therapeutic
approach
for
DOP.
We
synthesized
ferroptosis-suppressing
nanoparticles,
which
could
deliver
curcumin,
natural
compound,
marrow
using
tetrahedral
framework
nucleic
acid
(tFNA).
This
delivery
system
demonstrated
excellent
curcumin
bioavailability
stability,
as
well
synergistic
properties
tFNA.
Both
in
vitro
vivo
experiments
revealed
nanoparticles
enhance
mitochondrial
function
by
activating
nuclear
factor
E2-related
2
(NRF2)/glutathione
peroxidase
4
(GPX4)
pathway,
inhibiting
ferroptosis,
promoting
BMSCs
diabetic
microenvironment,
reducing
trabecular
loss,
increasing
formation.
These
findings
suggest
curcumin-containing
DNA
tetrahedron-based
have
promising
potential
DOP
other
ferroptosis-related
diseases.
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Dec. 6, 2023
Abstract
Although
aging
has
traditionally
been
viewed
as
the
most
important
risk
factor
for
osteoarthritis
(OA),
an
increasing
amount
of
epidemiological
evidence
highlighted
association
between
metabolic
abnormalities
and
OA,
particularly
in
younger
individuals.
Metabolic
abnormalities,
such
obesity
type
II
diabetes,
are
strongly
linked
to
they
affect
both
weight-bearing
non-weight-bearing
joints,
thus
suggesting
that
pathogenesis
OA
is
more
complicated
than
mechanical
stress
induced
by
overweight.
This
review
aims
explore
recent
advances
research
on
relationship
risk,
including
impact
abnormal
glucose
lipid
metabolism,
potential
targeted
therapeutic
strategies.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5364 - 5364
Published: March 10, 2023
Osteoarthritis
(OA)
is
a
worldwide
chronic
disease
that
can
cause
severe
inflammation
to
damage
the
surrounding
tissue
and
cartilage.
There
are
many
different
factors
lead
osteoarthritis,
but
abnormally
progressed
programmed
cell
death
one
of
most
important
risk
induce
osteoarthritis.
Prior
studies
have
demonstrated
death,
including
apoptosis,
pyroptosis,
necroptosis,
ferroptosis,
autophagy,
cuproptosis,
has
great
connection
with
In
this
paper,
we
review
role
types
in
generation
development
OA
how
signal
pathways
modulate
regulate
OA.
Additionally,
provides
new
insights
into
radical
treatment
osteoarthritis
rather
than
conservative
treatment,
such
as
anti-inflammation
drugs
or
surgical
operation.
Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 428 - 428
Published: Feb. 9, 2023
Autophagy
is
a
fundamental
homeostatic
process
in
which
certain
cellular
components
are
ingested
by
double-membrane
autophagosomes
and
then
degraded
to
create
energy
or
maintain
homeostasis
survival.
It
typically
observed
nutrient-deprived
cells
as
survival
mechanism.
However,
it
has
also
been
identified
crucial
maintaining
disease
progression.
Normal
metabolism
produces
reactive
oxygen
(ROS)
nitrogen
species
at
low
levels.
increased
production
causes
oxidative
stress,
can
lead
diabetes,
cardiovascular
diseases,
neurological
disorders,
cancer.
was
recently
shown
that
redox
equilibrium
via
autophagy
critical
for
responses
stress.
little
understood
about
the
molecular
cancer
processes
connect
control
of
autophagy.
In
cells,
oncogenic
mutations,
carcinogens,
metabolic
reprogramming
cause
ROS
generation
Recent
studies
have
suggested
activates
pathways
promote
development
metastasis.
Moreover,
relationship
between
programming
involved
malignant
phenotype.
Currently,
while
signaling
events
governing
how
affects
cascades
well
understood,
very
known
related
this
review,
we
focus
on
current
knowledge
modulation
role
further
stress
progression
regulation.
Therefore,
review
focuses
understanding
oxidation/reduction
fine-tune
help
understand
govern
cancer,
either
leading
cell
death
strategies
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
32, P. 164 - 176
Published: Oct. 9, 2023
Osteoarthritis
(OA)
has
emerged
as
a
significant
health
concern
among
the
elderly
population,
with
increasing
attention
paid
to
ferroptosis-induced
OA
in
recent
years.
However,
prolonged
use
of
nonsteroidal
anti-inflammatory
drugs
or
corticosteroids
can
lead
series
side
effects
and
limited
therapeutic
efficacy.
This
study
aimed
employ
Mannich
condensation
reaction
between
epigallocatechin-3-gallate
(EGCG)
selenomethionine
(SeMet)
efficiently
synthesize
polyphenol-based
nanodrugs
aqueous
media
for
treating
OA.
Molecular
biology
experiments
demonstrated
that
EGCG-based
(ES
NDs)
could
effectively
reduce
glutathione
peroxidase
4
(GPX4)
inactivation,
abnormal
Fe2+
accumulation,
lipid
peroxidation
induced
by
oxidative
stress,
which
ameliorated
metabolic
disorder
chondrocytes
other
multiple
pathological
processes
triggered
ferroptosis.
Moreover,
imaging
histopathological
analysis
destabilization
medial
meniscus
model
mice
confirmed
ES
NDs
exhibiting
relieving
The
intra-articular
delivery
represents
promising
approach
joint
inflammatory
diseases.
