Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 215 - 215

Published: Feb. 7, 2025

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.

Language: Английский

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Applications of Hydrogels in Osteoarthritis Treatment

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 923 - 923

Published: April 22, 2024

This review critically evaluates advancements in multifunctional hydrogels, particularly focusing on their applications osteoarthritis (OA) therapy. As research evolves from traditional natural materials, there is a significant shift towards synthetic and composite known for superior mechanical properties enhanced biodegradability. spotlights novel such as injectable microneedle technology, responsive which have revolutionized OA treatment through targeted efficient therapeutic delivery. Moreover, it discusses innovative hydrogel including protein-based superlubricating potential to reduce joint friction inflammation. The integration of bioactive compounds within hydrogels augment efficacy also examined. Furthermore, the anticipates continued technological deeper understanding hydrogel-based therapies. It emphasizes provide tailored, minimally invasive treatments, thus highlighting critical role advancing dynamic field biomaterial science management.

Language: Английский

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

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High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 517 - 533

Published: Feb. 21, 2024

Polymyxins are the last line of defense against multidrug-resistant (MDR) Gram-negative bacterial infections. However, this resort has been threatened by emergence superbugs carrying mobile colistin resistance gene-1

Language: Английский

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Engineered hydrogel microspheres for spheroids and organoids construction

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155131 - 155131

Published: Aug. 24, 2024

Language: Английский

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Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: May 1, 2024

Abstract Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting progression. This review illuminates novel approaches OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural lubrication, show promise restoring biomechanics and alleviating pain. delves into an array biomimetic lubricants, including polymer brush, nanocomposite hydrogel, nanoparticles, underscoring their roles anti‐inflammation, targeting, cartilage repair, drug delivery. Furthermore, the potential mesenchymal stem cells differentiate chondrocytes, coupled with delivery these exosomes via nanomaterials, has promoted cell therapy avenues for OA. also highlights function non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, antisense oligonucleotides impeding progression, nanomaterials facilitating delivery, thus advanced therapeutic possibilities immune evasion bone proliferation. Overall, this encapsulates evolution treatment from material cell, ultimately gene forecasting future where evolve toward integrated, personalized diagnostics therapeutics

Language: Английский

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Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 4, 2024

Abstract Osteoarthritis (OA) is a degenerative disease caused by variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss cartilage. Traditional treatment can only delay progression OA, classical delivery system have many side effects. In recent years, microspheres shown great application prospects in field OA treatment. Microspheres support cells, reproduce natural tissue microenvironment vitro vivo, are an efficient for release drugs or biological agents, which promote cell proliferation, migration, differentiation. Thus, they been widely used cartilage repair regeneration. this review, preparation processes, basic materials, functional characteristics various commonly systematically reviewed. Then it introduced surface modification strategies that improve properties discussed series applications microsphere functionalized scaffolds Finally, based on bibliometrics research, research development, future potential, possible hotspots therapy dynamically evaluated. The comprehensive systematic review will bring new understanding to OA.

Language: Английский

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Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160620 - 160620

Published: Feb. 1, 2025

Language: Английский

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Unlocking the potential of β-1,3-xylooligosaccharides from Caulerpa lentillifera: structural characterization, antioxidative and anti-osteoarthritis applications

Chemical and Biological Technologies in Agriculture, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 16, 2024

Abstract Background β-1,3-Xylooligosaccharides (XOS-3) extracted from Caulerpa lentillifera have shown potential antioxidative and anti-tumor properties, but research on their biological activities, particularly anti-osteoarthritis effects, is still in early stages. Results XOS-3 were produced by eco-friendly enzymatic hydrolysis, displaying a semi-crystalline structure with predominant xylose, xylobiose, xylotriose, xylotetraose components which confirmed IC, SEM, FT-IR, XRD analysis. Compared β-1,4-xylooligosaccharides, had stronger antioxidant the scavenging rate of O 2 •− DPPH • radicals was 82.31% 58.44% at 2.0 mg/mL respectively. In vitro studies, significantly improved cell viability IL-1β-induced rat chondrocytes 43.41 to 73.5% 100 μg/mL, demonstrating anti-inflammatory cartilage-protective effects modulating MMP13 COL2A1 expression. Conclusions The study displayed XOS-3, offering new visuals for development marine polysaccharides treatment osteoarthritis. Graphical

Language: Английский

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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 100 - 120

Published: Jan. 18, 2025

Language: Английский

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