Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Oct. 11, 2021

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote growth, angiogenesis, invasion metastasis, along extracellular matrix (ECM) remodeling even chemoresistance. Numerous previous studies have confirmed critical role interaction between cells in tumorigenesis development. However, recently, mutual effects immune (TIME) been identified as another key factor promoting progression. The TIME mainly consists distinct populations islets is highly associated antitumor immunological state TME. interact tumor-infiltrating well other within via secretion various cytokines, growth factors, chemokines, exosomes effector molecules, consequently shaping an immunosuppressive TME that enables cancer to evade surveillance system. In-depth interactions, particularly complicated mechanisms connecting cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding direct indirect crosstalk infiltrating further summarize possible immunoinhibitory induced by In addition, present current related CAF-targeting immunotherapies briefly describe some future perspectives CAF research end.

Language: Английский

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Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(7), P. 551 - 569

Published: May 17, 2021

Language: Английский

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Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

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Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Oct. 19, 2020

Abstract Metabolic reprogramming is reported to be one of the hallmarks cancer, which an adaptive mechanism by fast-growing cancer cells adapt their increasing energy demands. Recently, extracellular vesicles (EVs) known as exosomes have been recognized crucial signaling mediators in regulating tumor microenvironment (TME). Meanwhile, TME a highly heterogeneous ecosystem incorporating cells, fibroblasts, adipocytes, endothelial mesenchymal stem and matrix. Accumulated evidence indicates that may transfer biologically functional molecules recipient facilitate progression, angiogenesis, metastasis, drug resistance, immunosuppression metabolism surrounding stromal cells. In this review, we present role underlying how exacerbate development through metabolic reprogramming. addition, will also discuss potential targeting process biomarkers for diagnosis prognosis, exosomes-mediated targets therapy. Furthermore, better understanding link between reprogramming, impact on would provide novel insights prevention treatment future.

Language: Английский

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Staging and grading of oral squamous cell carcinoma: An update

Oral Oncology, Journal Year: 2020, Volume and Issue: 107, P. 104799 - 104799

Published: May 20, 2020

Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck region. OSCC has relatively low survival rate incidence disease increasing in some geographic areas. Staging grading are established prerequisites for management, as they influence risk stratification first step toward personalized treatment. The current AJCC/UICC TNM staging (8th edition, 2017) included significant modifications through incorporation depth invasion T stage extracapsular spread/extranodal extension N stage. Further AJCC 8 have been suggested. On other hand, World Health Organization (WHO) classification (4th still endorses simple, differentiation-based histopathologic system (despite its prognostic value) ignores factors such tumor growth pattern dissociation, stromal reactions (desmoplasia, local immune response), tumor-stroma ratio. various controversies possible developments criteria briefly discussed this update together with applications artificial intelligence context screening stratification.

Language: Английский

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Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Sept. 11, 2020

Abstract Immunotherapy (IO) has revolutionized the therapy landscape of non-small cell lung cancer (NSCLC), significantly prolonging overall survival (OS) advanced stage patients. Over recent years IO been broadly integrated into first-line setting non-oncogene driven NSCLC, either in combination with chemotherapy, or selected patients PD-L1 high expression as monotherapy. Still, a significant proportion suffer from disease progression. A better understanding resistance mechanisms depicts central goal to avoid overcome and improve patient outcome. We here review major cellular molecular pathways within tumor microenvironment (TME) that may impact evolution resistance. summarize upcoming treatment options after including novel targets (e.g. RIG-I, STING) well interesting combinational approaches such combined anti-angiogenic agents metabolic IDO-1, adenosine signaling, arginase). By discussing fundamental mode action TME, we aim understand manage seed new ideas for effective therapeutic concepts.

Language: Английский

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Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

Immunity, Journal Year: 2020, Volume and Issue: 52(1), P. 36 - 54

Published: Jan. 1, 2020

Language: Английский

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Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Biomolecules, Journal Year: 2022, Volume and Issue: 12(6), P. 784 - 784

Published: June 4, 2022

Cancer is one of the main causes death worldwide. To date, and despite advances in conventional treatment options, therapy cancer still far from optimal due to non-specific systemic biodistribution antitumor agents. The inadequate drug concentrations at tumor site led an increased incidence multiple resistance appearance many severe undesirable side effects. Nanotechnology, through development nanoscale-based pharmaceuticals, has emerged provide new innovative drugs overcome these limitations. In this review, we overview approved nanomedicine for rationale behind their designs applications. We also highlight approaches that are currently under investigation perspectives challenges nanopharmaceuticals, focusing on microenvironment disseminate cells as most attractive effective strategies treatments.

Language: Английский

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Exosomal miRNAs in tumor microenvironment

Journal of Experimental & Clinical Cancer Research, Journal Year: 2020, Volume and Issue: 39(1)

Published: April 16, 2020

Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of cells, fibroblasts, endothelial and immune as well non-cellular components, such exosomes cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, proteins, lipids nucleic acids. carry biologically miRNAs to shuttle between TME, thereby affecting development. Tumor-derived exosomal induce matrix reprogramming creating a that conducive growth, metastasis, escape chemotherapy resistance. In this review, we updated role process TME reshaping.

Language: Английский

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Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: March 9, 2021

Abstract The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, prognosis. However, recent advances based on bulk RNA sequencing remain insufficient construct an in-depth landscape infiltrating cells in NPC. Here we apply single-cell 66,627 from 14 patients, integrated with clonotype identification T B cells. We identify characterize five major clusters 36 distinct subpopulations genetic profiling. By comparing the non-malignant microenvironment, report highly representative features TME, including phenotypic abundance, alternations, immune dynamics, clonal expansion, developmental trajectory, molecular interactions that profoundly influence patient prognosis therapeutic outcome. key findings are further independently validated two cohorts RNA-sequencing cohorts. In present study, reveal correlation between NPC-specific characteristics progression-free survival. Together, these data facilitate dynamics NPC patients provides deeper insights into development prognostic biomarkers targets TME.

Language: Английский

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