Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

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Interplay of oxidative stress, cellular communication and signaling pathways in cancer

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment

Language: Английский

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Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

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Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 223 - 223

Published: Feb. 4, 2024

Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). may resolve issues related to the instability, fast degradation, bioavailability, insolubility of different drugs or natural compounds. can be very efficient potential systems specific delivery anticancer, antioxidant, anti-inflammatory, antimicrobial, antibacterial molecules. This review aims present overview their composition, most common formulation techniques, as well recent utilizations in cancer therapy.

Language: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

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Nanoparticles in cancer diagnosis and treatment: Progress, challenges, and opportunities

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105599 - 105599

Published: March 26, 2024

Despite considerable progress in patient care, the global incidence of various cancer types continues to rise. Developing safer and more efficient anti-cancer treatment approaches are great interest. In recent decades, nanotechnology has emerged as a promising innovative medical approach for diagnosis treatment. However, nanomedicine advances, it is important understand address challenges. Herein, we identify gaps current understanding effectiveness on clinical outcomes provide an outlook improved application medicine. We discuss use different nanoparticles therapy impact efficiency existing treatments, such chemotherapeutic, anti-angiogenic, immunotherapeutic drugs, radiotherapy. Additionally, update status trials nanoparticle-based treatments provided.

Language: Английский

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Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504

Published: April 23, 2024

Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.

Language: Английский

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Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 28, 2024

Triple-negative breast cancer (TNBC) poses significant challenges in oncology due to its aggressive nature, limited treatment options, and poorer prognosis compared other subtypes. This comprehensive review examines the therapeutic diagnostic landscape of TNBC, highlighting current strategies, emerging therapies, future directions. Targeted including PARP inhibitors, immune checkpoint EGFR hold promise for personalized approaches. Challenges identifying novel targets, exploring combination developing predictive biomarkers must be addressed optimize targeted therapy TNBC. Immunotherapy represents a transformative approach TNBC treatment, yet biomarker identification, overcoming resistance persist. Precision medicine approaches offer opportunities tailored based on tumor biology, but integration multi-omics data clinical implementation present requiring innovative solutions. Despite these challenges, ongoing research efforts collaborative initiatives hope improving outcomes advancing strategies By addressing complexities biology effective approaches, treatments can realized, ultimately enhancing lives patients. Continued research, trials, interdisciplinary collaborations are essential realizing this vision making meaningful progress management.

Language: Английский

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The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6099 - 6126

Published: June 1, 2024

Abstract: The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field nanotechnology, with a specific focus on nanocomposites. Nanocomposites, combination nanomaterials diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, therapeutic interventions. Nanocomposites exhibit great potential early detection accurate imaging diagnosis. Integrating various modalities, such magnetic resonance (MRI), computed tomography (CT), fluorescence into nanocomposites enables development contrast agents enhanced sensitivity specificity. Moreover, functionalizing targeting ligands ensures selective accumulation tumor tissues, facilitating precise diagnostic accuracy. On front, revolutionized by overcoming traditional challenges associated drug delivery. controlled release from nanocomposite carriers enhances bioavailability, reduces systemic toxicity, improves overall efficacy. Additionally, integration stimuli-responsive components within site-specific triggered unique microenvironment tumor. Despite remarkable progress field, biocompatibility, scalability, long-term safety profiles remain. This article provides comprehensive overview recent developments, challenges, prospects, emphasizing transformative revolutionizing landscape diagnostics therapeutics. In Conclusion, integrating heralds new era precision medicine. Keywords: nanocomposites, cancer, diagnosis, therapy, nanoparticles, theranostic

Language: Английский

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Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723

Published: July 4, 2024

Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.

Language: Английский

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