Mapping Heterogeneity of Hepatocellular Carcinoma by Investigating Hepatocyte-Specific Genes/TFs/Pathways Across Cellular and Tumor Landscapes DOI Creative Commons
Ovais Shafi,

Rahimeen Rajpar,

Shakaib Zafar

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract Background: Hepatocellular carcinoma (HCC) presents challenges due to tumor heterogeneity and therapeutic resistance. Understanding the molecular mechanisms driving is crucial. Key transcription factors (HNF4A, HNF1A, FOXA1/2, etc.) signaling pathways (Wnt/β-catenin, FGF, HGF, are dysregulated in HCC. Dysregulation disrupts hepatocyte genetic programming, leading heterogeneous cell populations. Investigating these offers insights for targeted therapies improving patient outcomes Methods: Databases, including PubMed, MEDLINE, Google Scholar, open access/ subscription-based journals were searched published articles without any date restrictions, trace emergence of HCC by investigating hepatocyte-specific genes/TFs/signaling across cellular landscapes. Based on criteria mentioned methods section, studies systematically reviewed investigate Heterogeneity. This study adheres relevant PRISMA guidelines (Preferred Reporting Items Systematic Reviews Meta-Analyses). Results: into hepatocellular revealed dysregulation key (TFs) pathways. Transcription HNF4A, CEBPA, GATA4/6, PROX1, SOX9, HNF6/Onecut1, ONECUT2/HNF6β showed altered expression patterns, disrupting programming promoting populations Dysregulated Wnt/β-catenin, TGF-β, Hippo influenced fate decisions interactions with microenvironment, further contributing heterogeneity. NOTCH TBX3/18 highlighted complexity points critical role TFs transdifferentiation, providing interventions improve outcomes. Conclusion: The decline gene type-specific genes dysregulates programing hepatocytes involved homeostasis. multiple roles every gene/TF begin manifest themselves causing homeostasis, transdifferentiation. like along such as Wnt/β-catenin signaling, play crucial roles. disruption sets stage diverse phenotypes within microenvironment. vital developing strategies address

Language: Английский

ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation DOI
Lei Wang,

Runze Shi,

Shuo Wang

et al.

Nature Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

2
Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles DOI Creative Commons
Artem Ten, Vadim Kumeiko, Vladislav M. Farniev

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 682 - 682

Published: April 15, 2024

The tumor microenvironment (TME) plays an important role in the process of tumorigenesis, regulating growth, metabolism, proliferation, and invasion cancer cells, as well contributing to resistance conventional chemoradiotherapies. Several types cells with relatively stable phenotypes have been identified within TME, including cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), neutrophils, natural killer (NK) which shown modulate cell metastasis, interaction immune system, thus promoting heterogeneity. Growing evidence suggests that tumor-cell-derived extracellular vesicles (EVs), via transfer various molecules (e.g., RNA, proteins, peptides, lipids), play a pivotal transformation normal TME into their protumorigenic counterparts. This review article focuses on functions EVs modulation view how exosomes contribute importance for diagnosis therapy.

Language: Английский

Citations

9
Precision surgery for hepatocellular carcinoma DOI
Christian Tibor Josef Magyar, Luckshi Rajendran, Zhihao Li

et al.

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis DOI Creative Commons
Lin Zhu,

Qianqian Meng,

Weiyi Qian

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317454 - e0317454

Published: Jan. 17, 2025

Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and third leading cause of death worldwide. Hepatocellular (HCC) accounts for 75%-85% PHC. LARP3 aberrantly expressed in multiple cancers. We found that it significantly highly liver tissues HCC patients, but exact role specific mechanism this abnormal expression are not yet clear. In study, through bioinformatics analysis, we concluded associated with a poor prognosis patients HCC. Through cellular experiments such as gene editing phenotypic functions, promotes occurrence development inhibits apoptosis. Finally, biological means RNA sequencing, flow cytometry, western blotting, construction subcutaneous tumorigenesis model nude mice, inhibition apoptosis by related to negatively regulating ROS level inhibiting PI3K/c-Fos/apoptosis axis. This study will provide potential targets treatment

Language: Английский

Citations

0
Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis DOI

K C Chen,

Huabo Wang,

Bingwei Ma

et al.

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection DOI Creative Commons
Guoyi Xia,

Ze‐Yan Yu,

Shaolong Lu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 20, 2025

This investigation aimed to create a new nomogram based on complement C3 forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery. study encompassed 1234 treated resection at the Affiliated Cancer Hospital of Guangxi Medical University. The cohort for primary included 865 from December 2015 2019, while validation comprised 369 patients. Follow-ups were conducted regularly until 2024. Variables predicting identified using Cox regression analyses, these, was constructed. nomogram's accuracy assessed via time-dependent ROC curves, calibration curves KM curve analyses. Investigations C3, PT, presence cirrhosis, tumor capsule, MVI-M2 as distinct predictors HCC Based these findings, predictive constructed validated, estimating OS. efficacy validated through analyses each demonstrating positive outcomes. Additionally, analysis effectively separated patient populations into two prognostic risk categories within both cohorts. In conclusion, has been developed corroborated multivariate analysis, early stages following surgical resection. tool proven be more effective forecasting outcomes such

Language: Английский

Citations

0
Enhanced prediction of 5-year postoperative recurrence in hepatocellular carcinoma by incorporating LASSO regression and random forest models DOI

Bing-Bing Su,

Chunhui Zhu, Jun Cao

et al.

Surgical Endoscopy, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Latent class analysis‐derived classification for cancer‐specific death stratification of hepatocellular carcinoma DOI Open Access
Xiaoyan Jiang, Qianyuan Zhang, Zhong Zheng

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

The heterogeneity in prognostic survival and treatment response of hepatocellular carcinoma (HCC) limits the accurate assessment HCC-specific mortality. This study aimed to identify potential HCC subtypes through latent class analysis (LCA) improve mortality prediction optimize recommendations. We analyzed data from 7746 patients Surveillance, Epidemiology, End Results (SEER) databases, incorporating demographic clinicopathological information applying LCA subtypes. Prognostic across different were evaluated utilizing Cox proportional hazards regression competing risks models. classification was externally validated with 6791 patients. Four (LCAC1-LCAC4) determined. Compared LCAC1, both LCAC2 (HR = 1.887, p < .001) LCAC4 1.317, associated significantly shorter overall survival. had highest (HR: 2.395, .001), followed by 1.531, LCAC3 1.424, .001). lowest risk non-HCC-specific 0.613, Surgical treatment, particularly preoperative systemic therapy, improved all subtypes, whereas chemotherapy radiotherapy limited efficacy LCAC1 External validation corroborated these findings. provides a system that differentiates mortality, facilitating stratification recommendations, valuable insight for clinical decision-making.

Language: Английский

Citations

0
Integrated Analysis of Bulk and Single-Cell RNA Sequencing Data Reveal a Novel Prognostic Signature of Combining Cuproptosis- and Ferroptosis-Related Genes in Hepatocellular Carcinoma DOI Open Access

Hua Wei,

Jia‐Xin Peng

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2779 - 2779

Published: March 19, 2025

As a common malignancy, hepatocellular carcinoma (HCC) proliferation and metastasis could be promoted by ferroptosis cuproptosis. In this study, we screened out the differentially expressed cuproptosis- ferroptosis-related genes (CFRGs) identified 17 informative prognosis-associated genes. A CFRG scoring model was constructed based on subtypes consensus clustering analysis principal component (PCA). Furthermore, immune profile, expression of checkpoint (ICGs) drug susceptibility were also compared between two score groups. The results showed that patients with high had higher survival probabilities. correlation suggested scores negatively correlated activated CD4.T.cell. patterns thirty ICGs half-maximal inhibitory concentration (IC50) values 128 drugs displayed significant differences statistically difference in efficacy sorafenib found Moreover, multivariate COX regression weighted gene co-expression network (WGCNA), DLAT SLC2A1 as signature Molecular docking revealed strong binding affinity toward camptothecin, rapamycin, dactolisib, luminespib. single-cell characteristics further explored. study depended our understanding biological function CFRGs HCC provided new insights for developing treatment strategies.

Language: Английский

Citations

0
Myeloid cell path to malignancy: insights into liver cancer DOI Creative Commons
Christel Ramirez, Leila Akkari

Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0