Exosomes in infectious diseases: insights into leishmaniasis pathogenesis, immune modulation, and therapeutic potential DOI

Abida Khan,

Hayaa M. Alhuthali,

Jawaher Mohammad Alshehri

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

An Integrating Microfluidic System for Concentration Gradient Generation of Exosomes and Exosome-Assisted Single-Cell-Derived Tumor-Sphere Formation DOI

Long Pang,

Chang Tian, Qirui Wang

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

To enhance exploration on tumor stem-like cells (TSCs) without altering their cellular biological characteristics, researchers advocate for application of single-cell-derived tumor-spheres (STSs). TSCs are regulated by surrounding microenvironment, making it crucial to simulate a microenvironment facilitate STS formation. Recently, exosomes that originated from the have emerged as promising approach mimicking microenvironment. In various associated (such fibroblasts, endothelial cells, and immune cells) play roles. Utilizing derived these enabled us promote Herein, we developed an integrated microfluidic platform generate serial concentration gradients evaluate effects multiple demonstrate feasibility our approach, generated two different cell types (HUVEC NIH/3T3 assessed Subsequently, investigated drug resistance STSs treated with free doxorubicin doxorubicin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Our findings revealed mixed could be successfully generated, leading enhanced formation rate size STSs. Compared one type, exhibited superior promotion Additionally, nanomedicines demonstrated reduction in compared treatment, particularly smaller and/or more deformable TSCs. This provides innovative enhancement simulation.

Language: Английский

Citations

1

Extracellular vesicles in uveal melanoma - biological roles and diagnostic value DOI Creative Commons
Ornella Urzì, Roger Olofsson Bagge, Rossella Crescitelli

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217531 - 217531

Published: Feb. 1, 2025

Language: Английский

Citations

0

Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate DOI

Xinyu Dou,

Chunyu Feng, Ji Li

et al.

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications DOI Creative Commons
Çıgır Biray Avci, Bakiye Göker Bağca, Masoud Nikanfar

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 12, 2024

The tumor microenvironment (TME) plays a crucial role in cancer development and metastasis. This review summarizes the current research on how TME promotes metastasis through molecular pathways, focusing key components, such as cancer-associated fibroblasts, immune cells, endothelial cytokines, extracellular matrix. Significant findings have highlighted that alterations cellular communication within enable cells to evade surveillance, survive, invade other tissues. highlights roles of TGF-β VEGF signaling promoting angiogenesis matrix remodeling, which facilitate Additionally, we explored metabolic reprogramming stromal influenced by nutrient availability TME, drives progression. study also evaluated therapeutic strategies targeting these interactions disrupt By providing multidisciplinary perspective, this suggests understanding basis can lead more effective therapies identify potential avenues for future research. Future should prioritize unraveling complex environment, could novel personalized treatments. Moreover, advancements technologies single-cell analysis, spatial transcriptomics, epigenetic profiling offer promising identifying new targets improving efficacy immunotherapies, particularly context

Language: Английский

Citations

3

Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment DOI Open Access
Artur Nieszporek, Małgorzata Wierzbicka, Natalia Łabędź

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3298 - 3298

Published: Sept. 27, 2024

Salivary gland tumors (SGTs) are rare and diverse neoplasms, presenting significant challenges in diagnosis management due to their rarity complexity. Exosomes, lipid bilayer vesicles secreted by almost all cell types present body fluids, have emerged as crucial intercellular communication agents. They play multifaceted roles tumor biology, including modulating the microenvironment, promoting metastasis, influencing immune responses.

Language: Английский

Citations

2

Tumor-derived exosomes: unravelling the pathogenesis of pancreatic cancer with liver metastases and exploring the potential for clinical translation DOI
Dongqi Li, Xiangyu Chu, Yongsu Ma

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217403 - 217403

Published: Dec. 19, 2024

Language: Английский

Citations

2

Prognostic value and anti-tumor immunity role of TMED9 in pan-cancer: a bioinformatics study DOI Open Access

Haodi Wang,

Yue Wang,

Pengyu Tan

et al.

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5429 - 5445

Published: Sept. 23, 2024

Transmembrane p24 trafficking protein 9 (

Language: Английский

Citations

1

Exosomes in esophageal cancer: a promising frontier for liquid biopsy in diagnosis and therapeutic monitoring DOI Creative Commons

Ren Zihan,

Cao Jingsi,

Ding Lingwen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Esophageal cancer is a common and lethal digestive system malignancy, both treatment efficacy patient survival rates face significant challenges. In recent years, exosomes have emerged as crucial mediators of intercellular communication, demonstrating tremendous clinical potential, particularly in the diagnosis, treatment, prognostic evaluation esophageal cancer. These not only serve biomarkers for early diagnosis prognosis but also modulate tumor growth, metastasis, drug resistance by delivering bioactive molecules. Importantly, can act carriers cancer-related therapeutic agents, optimizing gene therapy strategies to enhance while reducing toxicity side effects. Despite facing challenges applications such purification, enrichment, standardization analytical methods, maintain broad prospects application with potential significantly improve outcomes quality life. This review focuses on innovative role cancer, exploring their value safety disease monitoring assessment response. Furthermore, this study outlines limitations transitioning exosome research from basic studies applications, well solutions future directions address these obstacles.

Language: Английский

Citations

1

Exosomes in infectious diseases: insights into leishmaniasis pathogenesis, immune modulation, and therapeutic potential DOI

Abida Khan,

Hayaa M. Alhuthali,

Jawaher Mohammad Alshehri

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

Citations

0