Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Language: Английский
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
To enhance exploration on tumor stem-like cells (TSCs) without altering their cellular biological characteristics, researchers advocate for application of single-cell-derived tumor-spheres (STSs). TSCs are regulated by surrounding microenvironment, making it crucial to simulate a microenvironment facilitate STS formation. Recently, exosomes that originated from the have emerged as promising approach mimicking microenvironment. In various associated (such fibroblasts, endothelial cells, and immune cells) play roles. Utilizing derived these enabled us promote Herein, we developed an integrated microfluidic platform generate serial concentration gradients evaluate effects multiple demonstrate feasibility our approach, generated two different cell types (HUVEC NIH/3T3 assessed Subsequently, investigated drug resistance STSs treated with free doxorubicin doxorubicin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Our findings revealed mixed could be successfully generated, leading enhanced formation rate size STSs. Compared one type, exhibited superior promotion Additionally, nanomedicines demonstrated reduction in compared treatment, particularly smaller and/or more deformable TSCs. This provides innovative enhancement simulation.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 12, 2024
The tumor microenvironment (TME) plays a crucial role in cancer development and metastasis. This review summarizes the current research on how TME promotes metastasis through molecular pathways, focusing key components, such as cancer-associated fibroblasts, immune cells, endothelial cytokines, extracellular matrix. Significant findings have highlighted that alterations cellular communication within enable cells to evade surveillance, survive, invade other tissues. highlights roles of TGF-β VEGF signaling promoting angiogenesis matrix remodeling, which facilitate Additionally, we explored metabolic reprogramming stromal influenced by nutrient availability TME, drives progression. study also evaluated therapeutic strategies targeting these interactions disrupt By providing multidisciplinary perspective, this suggests understanding basis can lead more effective therapies identify potential avenues for future research. Future should prioritize unraveling complex environment, could novel personalized treatments. Moreover, advancements technologies single-cell analysis, spatial transcriptomics, epigenetic profiling offer promising identifying new targets improving efficacy immunotherapies, particularly context
Language: Английский
Citations
5
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217531 - 217531
Published: Feb. 1, 2025
Language: Английский
Citations
0
Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
3
Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217403 - 217403
Published: Dec. 19, 2024
Language: Английский
Citations
3
Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3298 - 3298
Published: Sept. 27, 2024
Salivary gland tumors (SGTs) are rare and diverse neoplasms, presenting significant challenges in diagnosis management due to their rarity complexity. Exosomes, lipid bilayer vesicles secreted by almost all cell types present body fluids, have emerged as crucial intercellular communication agents. They play multifaceted roles tumor biology, including modulating the microenvironment, promoting metastasis, influencing immune responses.
Language: Английский
Citations
2
Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5429 - 5445
Published: Sept. 23, 2024
Transmembrane p24 trafficking protein 9 (
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 17, 2024
Esophageal cancer is a common and lethal digestive system malignancy, both treatment efficacy patient survival rates face significant challenges. In recent years, exosomes have emerged as crucial mediators of intercellular communication, demonstrating tremendous clinical potential, particularly in the diagnosis, treatment, prognostic evaluation esophageal cancer. These not only serve biomarkers for early diagnosis prognosis but also modulate tumor growth, metastasis, drug resistance by delivering bioactive molecules. Importantly, can act carriers cancer-related therapeutic agents, optimizing gene therapy strategies to enhance while reducing toxicity side effects. Despite facing challenges applications such purification, enrichment, standardization analytical methods, maintain broad prospects application with potential significantly improve outcomes quality life. This review focuses on innovative role cancer, exploring their value safety disease monitoring assessment response. Furthermore, this study outlines limitations transitioning exosome research from basic studies applications, well solutions future directions address these obstacles.
Language: Английский
Citations
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Language: Английский
Citations
1