Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis DOI Creative Commons
Yili Chen, Wen Zhao,

An Bin Hu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 30, 2024

With the aging global population, type 2 diabetes mellitus (T2DM) and osteoporosis(OP) are becoming increasingly prevalent. Diabetic osteoporosis (DOP) is a metabolic bone disorder characterized by abnormal tissue structure reduced strength in patients with diabetes. Studies have revealed close association among diabetes, increased fracture risk, disturbances iron metabolism. This review explores concept of ferroptosis, non-apoptotic cell death process dependent on intracellular iron, focusing its role DOP. Iron-dependent lipid peroxidation, particularly impacting pancreatic β-cells, osteoblasts (OBs) osteoclasts (OCs), contributes to The intricate interplay between dysregulation, which comprises deficiency overload, DOP has been discussed, emphasizing how excessive accumulation triggers ferroptosis concise overview highlights need understand complex relationship T2DM OP, ferroptosis. aimed elucidate pathogenesis provide prospective for future research targeting interventions field

Language: Английский

Ferroptosis in health and disease DOI Creative Commons
Carsten Berndt, Hamed Alborzinia,

Vera Skafar Amen

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

Citations

69
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury DOI Creative Commons
Xuexian Fang, Jiawei Zhang, You Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 25, 2023

Abstract Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, mechanistic basis remains unclear. In this study, using a mouse model I/R injury, it is observed that glutathione (GSH) and cysteine depletion are associated with deficiency reducing power nicotinamide adenine dinucleotide phosphate (NADPH). Genes involved in maintaining NADPH homeostasis screened, identified I/R‐induced ferroptosis significantly reduced expression activity NADP + ‐dependent malic enzyme 1 (Me1). Mice hepatocyte‐specific Me1 gene deletion exhibit aggravated liver under treatment; while supplementation L‐malate, substrate ME1, restores GSH levels eventually inhibits injury. A study further reveals downregulation largely mediated phosphatase tensin homologue (PTEN)‐dependent suppression target rapamycin/sterol regulatory element‐binding protein (mTOR/SREBP1) signaling pathway model. Finally, PTEN inhibitor, mTOR activator, or SREBP1 over‐expression all increase NADPH, block ferroptosis, protect against Taken together, findings suggest targeting ME1 may provide new therapeutic opportunities for other ferroptosis‐related conditions.

Language: Английский

Citations

60
GPX4, ferroptosis, and diseases DOI Open Access

Wangzheqi Zhang,

Yang Liu,

Liao Yan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116512 - 116512

Published: April 3, 2024

GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing significant role maintaining the redox homeostasis within body. Ferroptosis, form of iron-dependent non-apoptotic cell death, has gained considerable attention recent years due to its involvement multiple pathological processes. is closely associated with ferroptosis functions primary inhibitor this process. Together, contribute pathophysiology several diseases, including sepsis, nervous system ischemia reperfusion injury, cardiovascular cancer. This review comprehensively explores roles impacts development progression these aim providing insights for identifying potential therapeutic strategies future.

Language: Английский

Citations

58
Tactile Sensors: Hydroxyl Decorated Silver Metal–Organic Frameworks for Detecting Cr2O72–, MnO4–, Humic Acid, and Fe3+ Ions DOI
Brij Mohan,

Shixuan Ma,

Sandeep Kumar

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(13), P. 17317 - 17323

Published: March 24, 2023

Anionic, acidic, and metal ions are common contaminants in water cause serious concerns for human aquatic life. With the goal of rapid detection analytes, we herein design a new array ligand 5-(4H-1,2,4-triazol-4-yl)pyridin-3-ol-linked silver coordinated metal-organic frameworks Ag-MOFs as promising sensor Cr2O72-, MnO4-, humic acid (HA), Fe3+ down to micro level. Furthermore, evidenced by luminescence, excitation-emission matrix (EEM) spectroscopic, PXRD measurements, designed (MOFs) can be fast, stable, reusable analyte water.

Language: Английский

Citations

52
Zooming in and out of ferroptosis in human disease DOI
Xue Wang, Ye Zhou, Junxia Min

et al.

Frontiers of Medicine, Journal Year: 2023, Volume and Issue: 17(2), P. 173 - 206

Published: April 1, 2023

Language: Английский

Citations

52
Ironing out the role of ferroptosis in immunity DOI Creative Commons
Hannah N. Bell, Brent R. Stockwell, Weiping Zou

et al.

Immunity, Journal Year: 2024, Volume and Issue: 57(5), P. 941 - 956

Published: May 1, 2024

Ferroptosis is a type of regulated cell death that drives the pathophysiology many diseases. Oxidative stress detectable in types death, but only ferroptosis involves lipid peroxidation and iron dependency. originates propagates from several organelles, including mitochondria, endoplasmic reticulum, Golgi, lysosomes. Recent data have revealed immune cells can both induce undergo ferroptosis. A mechanistic understanding how regulates immunity critical to controls responses this dysregulated disease. Translationally, more work needed produce ferroptosis-modulating immunotherapeutics. This review focuses on role immune-related diseases, infection, autoimmune cancer. We discuss immunity, regulation contributes disease pathogenesis, targeting may lead novel therapies.

Language: Английский

Citations

48
Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases DOI Creative Commons
Qian Huang, Yi Ru, Ying‐Li Luo

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(13)

Published: March 29, 2024

Ferroptosis is a form of iron-dependent, lipid peroxidation–driven regulatory cell death that has been implicated in the pathogenesis multiple diseases, including organ injury, ischemia/reperfusion, and neurodegenerative diseases. However, inhibitors directly specifically target ferroptosis are not yet available. Here, we identify compound AS-252424 (AS) as potent inhibitor through kinase library screening. Our results show AS effectively inhibits peroxidation both human mouse cells. Mechanistically, binds to glutamine 464 ACSL4 inhibit its enzymatic activity, resulting suppression ferroptosis. By using nanoparticle-based delivery systems, treatment with AS-loaded nanoparticles alleviate ferroptosis-mediated injury models, kidney ischemia/reperfusion acute liver (ALI). Thus, our specific targeted remarkable antiferroptosis function, providing potential therapeutic for ferroptosis-related

Language: Английский

Citations

35
Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway DOI

Yanyan Deng,

Xiaoyue Chu,

Qian Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155458 - 155458

Published: Feb. 22, 2024

Language: Английский

Citations

28
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis DOI Creative Commons
Naoya Yamada, Tadayoshi Karasawa, Junya Ito

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 12, 2024

Abstract Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, organ-specific regulation mechanism poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), terminal enzyme cholesterol biosynthesis, as a regulator hepatocytes. Genetic and pharmacological inhibition (with AY9944) DHCR7 suppress human hepatocellular carcinoma Huh-7 cells. increases its substrate, (7-DHC). Furthermore, exogenous 7-DHC supplementation using hydroxypropyl β-cyclodextrin suppresses ferroptosis. A 7-DHC-derived oxysterol metabolite, 3β,5α-dihydroxycholest-7-en-6-one (DHCEO), increased by ferroptosis-inducer RSL-3 -deficient cells, suggesting that ferroptosis-suppressive effect associated with oxidation 7-DHC. Electron spin resonance analysis reveals functions radical trapping agent, thus protecting cells from We further show AY9944 inhibits hepatic ischemia-reperfusion injury, genetic ablation Dhcr7 prevents acetaminophen-induced acute failure mice. These findings provide new insights into regulatory suggest potential therapeutic option for ferroptosis-related diseases.

Language: Английский

Citations

28
Phytochemicals and Their Usefulness in the Maintenance of Health DOI Creative Commons

Elda Victoria Rodríguez-Negrete,

Ángel Morales‐González, Eduardo Madrigal‐Santillán

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(4), P. 523 - 523

Published: Feb. 15, 2024

Inflammation is the immune system’s first biological response to infection, injury, or irritation. Evidence suggests that anti-inflammatory effect mediated by regulation of various inflammatory cytokines, such as nitric oxide, interleukins, tumor necrosis factor alpha-α, interferon gamma-γ, well non-cytokine mediator, prostaglandin E2. Currently, mechanism action and clinical usefulness phytochemicals known; their on activity free radicals, oxidative stress. The latter are great relevance in development diseases, evidence collected demonstrates beneficial effects maintaining health. Epidemiological indicates regular consumption fruits vegetables related a low risk developing cancer other chronic diseases.

Language: Английский

Citations

26