Novel Insights into the Links between N6-Methyladenosine and Regulated Cell Death in Musculoskeletal Diseases DOI Creative Commons
Juanjuan Han, C Wang, Haolin Yang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(5), P. 514 - 514

Published: April 24, 2024

Musculoskeletal diseases (MSDs), including osteoarthritis (OA), osteosarcoma (OS), multiple myeloma (MM), intervertebral disc degeneration (IDD), osteoporosis (OP), and rheumatoid arthritis (RA), present noteworthy obstacles associated with pain, disability, impaired quality of life on a global scale. In recent years, it has become increasingly apparent that N6-methyladenosine (m6A) is key regulator in the expression genes multitude biological processes. m6A composed 0.1–0.4% adenylate residues, especially at beginning 3′-UTR near translation stop codon. The can be classified into three types, namely “writer”, “reader”, “eraser”. Studies have shown epigenetic modulation influences mRNA processing, nuclear export, translation, splicing. Regulated cell death (RCD) autonomous orderly cells under genetic control to maintain stability internal environment. Moreover, distorted RCDs are widely used influence course various receiving increasing attention from researchers. past few evidence indicated regulate gene thus different RCD processes, which central role etiology evolution MSDs. currently confirmed autophagy-dependent death, apoptosis, necroptosis, pyroptosis, ferroptosis, immunogenic NETotic oxeiptosis. m6A–RCD axis inflammatory response chondrocytes invasive migratory MM bone remodeling capacity, thereby influencing development This review gives complete overview regulatory functions across muscle, bone, cartilage. addition, we also discuss advances by m6A-targeted factors explore clinical application prospects therapies targeting MSD prevention treatment. These may provide new ideas directions for understanding pathophysiological mechanism MSDs treatment these diseases.

Language: Английский

Mechanisms controlling cellular and systemic iron homeostasis DOI
Bruno Galy, Marcus Conrad, Martina U. Muckenthaler

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(2), P. 133 - 155

Published: Oct. 2, 2023

Language: Английский

Citations

290
Inhalation exposure to polystyrene nanoplastics induces chronic obstructive pulmonary disease-like lung injury in mice through multi-dimensional assessment DOI
Sheng Yang, Tianyi Zhang, Yiling Ge

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 347, P. 123633 - 123633

Published: Feb. 27, 2024

Language: Английский

Citations

16
Ferroptosis in ulcerative colitis: Potential mechanisms and promising therapeutic targets DOI Open Access

Dan Long,

Chenhan Mao,

Yingtao Huang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722

Published: May 9, 2024

Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.

Language: Английский

Citations

16
Unwinding circular RNA’s role in inflammatory pulmonary diseases DOI
Asif Ahmad Bhat, Gaurav Gupta, Ahsas Goyal

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(5), P. 2567 - 2588

Published: Nov. 2, 2023

Language: Английский

Citations

40
H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alzheimer-like pathology through mTOR-regulated autophagy and activation of microglia DOI
Hailan Wang,

Haibo Xia,

Jun Bai

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137310 - 137310

Published: Jan. 21, 2025

Language: Английский

Citations

1
The Emerging Role of m6A and Programmed Cell Death in Cardiovascular Diseases DOI Creative Commons
Haixia Wang, Juanjuan Han, Hui Kong

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 247 - 247

Published: Feb. 8, 2025

N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, binding proteins. These regulate mRNA stability, splicing, nuclear export, translation, degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, necroptosis, plays crucial role maintaining cellular homeostasis, tissue development, function. Recently, m6A has emerged as significant research area due to regulating PCD implications cardiovascular diseases (CVDs). In this review, we delve into intricate relationship between various types modification, emphasizing their pivotal roles initiation progression of CVDs such myocardial ischemia-reperfusion (I/R), atherosclerosis (AS), pulmonary hypertension (PH), cardiomyopathy, doxorubicin (Dox)-induced cardiotoxicity (DIC), heart failure (HF), infarction (MI). Our findings underscore potential elucidating CVD pave new pathways for prevention treatment strategies.

Language: Английский

Citations

1
DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell DOI Creative Commons
Zihang Zeng,

Tiao Li,

Xiangming Liu

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102916 - 102916

Published: Oct. 4, 2023

Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality currently. Long-term exposure cigarette smoke (CS) inducing persistent inflammation, small airway remodeling emphysematous lung are the distinguishing features COPD. Ferroptosis, occurred in epithelial cells has recently been reported to be associated with COPD pathogenesis. DNA dioxygenase ten-eleven translocation 2 (TET2) an important demethylase its genetic mutation low forced expiratory volume 1 s (FEV1) function. However, role remains elusive. Here, we found that TET2 regulates CS induced lipid peroxidation through demethylating glutathione peroxidase 4 (GPx4), thus alleviating cell ferroptosis protein levels were mainly reduced epithelia patients, mouse models, extract-treated bronchial cells. The deletion triggered further exaggerated CS-induced remodeling, emphysema vivo. Moreover, demonstrated silencing intensified ferroptosis, while overexpression inhibited treated CSE. Mechanically, protected from promoter (GPx4). Finally, co-administration methylation inhibitor 5′-aza-2′-deoxycytidine (5-AZA) antioxidant N-acetyl-cysteine (NAC) have more protective effects on than either administration alone. Overall, our study reveals essential modulator cell, could act as potential therapeutic target for

Language: Английский

Citations

18
Soot nanoparticles promote ferroptosis in dopaminergic neurons via alteration of m6A RNA methylation in Parkinson’s disease DOI

Jiezhu Feng,

Piao Zhang,

Kunlin Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134691 - 134691

Published: May 22, 2024

Language: Английский

Citations

8
A deep insight into ferroptosis in lung disease: facts and perspectives DOI Creative Commons
Fan Zhang, Xiang Yu, Qiao Ma

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 18, 2024

In the last decade, ferroptosis has received much attention from scientific research community. It differs other modes of cell death at morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent caused lipid peroxide excess accompanied abnormal iron metabolism oxidative stress. recent years, more studies have shown that closely related to occurrence development lung diseases. COPD, asthma, injury, fibrosis, cancer, infection respiratory diseases become third most common chronic worldwide, bringing serious economic psychological burden people around world. However, exact mechanism which involved in progression not been fully revealed. this manuscript, we describe ferroptosis, targeting signaling pathways proteins, summarize relationship between diseases, explore intervention targeted therapy for

Language: Английский

Citations

6
The Regulation of Ferroptosis by Noncoding RNAs DOI Open Access
Xiangnan Zheng, Cen Zhang

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13336 - 13336

Published: Aug. 28, 2023

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which different from other death forms morphologically, biochemically, immunologically. Ferroptosis metabolism, antioxidant defense systems as well various transcription factors related signal pathways. Emerging evidence has highlighted that associated with many physiological pathological processes, including cancer, neurodegeneration diseases, cardiovascular ischemia/reperfusion injury. Noncoding RNAs are group functional RNA molecules not translated into proteins, can regulate gene expression in manners. An increasing number studies have shown noncoding RNAs, especially miRNAs, lncRNAs, circRNAs, interfere the progression modulating ferroptosis-related genes or proteins directly indirectly. In this review, we summarize basic mechanisms regulations focus on recent mechanism for types ncRNAs to conditions, will deepen our understanding regulation provide new insights employing ferroptosis-associated therapeutic strategies.

Language: Английский

Citations

15