DDHD2 is involved in the malignant progression of early luminal A breast cancer by changing cell membrane proteins and immune responses functionality DOI Creative Commons
Yawen Song, Liantao Guo, Deguang Kong

et al.

Oncology and Translational Medicine, Journal Year: 2024, Volume and Issue: 10(5), P. 231 - 244

Published: Sept. 2, 2024

Abstract Background Luminal A breast cancer has the best prognosis of all malignant types. In clinical practice, some patients with luminal present small tumors (usually <20 mm) but lymph node metastases or even distant organ metastasis. Owing to their insensitivity chemotherapy and lack conclusive evidence, there is a significant gap in research on high invasiveness. This study aimed identify genes that drive invasiveness explore underlying mechanisms. Methods this study, we first utilized bioinformatics techniques analyze differentially expressed mRNAs enrich common functional pathways target gene DDHD domain containing 2 (DDHD2). We then evaluated association between DDHD2 expression patient prognosis, genetic material changes, transcriptional, translational, immune responses cancer. also conducted experiments at molecular cellular levels validate these biochemical Results The varied low-grade without metastases. Our findings demonstrated exerted carcinogenic effects through various by altering cell adhesion migration, regulating proliferation apoptosis cycles, suppressing responses. Moreover, pathway which inhibited immunity was preliminarily verified. Conclusions results revealed novel role for promoting transformation Considering its tumor microenvironment tumor-infiltrating cells epithelial-mesenchymal transition, proposed as reliable direction future immunotherapy potential resistance.

Language: Английский

Mechanisms mediating arylidene-indolinones induced degradation: thoughts on “Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype” DOI Open Access
Chao Zhong, Ziying Wang, Zhaoyang Li

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Abstract In the recent issue of Nature Communications (2023 Nov 30;14(1):7908), Xue et. al. reported a very interesting and significant discovery possible DCAF11 ligand chemotype that could be used as “warhead” to design bifunctional compounds for targeted degradation via engaging E3 ligase 1 (annotated ref hereafter). The is importance protein field was inspired by previous reports suggesting similar may also engage autophagosome LC3 function autophagy-tethering (ATTECs) 2, 3, 4, 5, 6, 7 , which seem inconsistent with 1. We think conclusions based on these data are not necessarily mutually exclusive. After performing additional experiments analyses, we would like discuss some possibilities explaining such discrepancies make few points clarification.

Language: Английский

Citations

3
Lipid Droplets degradation mechanisms from microalgae to mammals, a comparative overview. DOI Creative Commons

Chems Amari,

Marta Carletti,

Siqi Yan

et al.

Biochimie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3
Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein DOI
Magdalena M. Bolsinger, Tim E. Moors,

Lisa Brontesi

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Glycerophospholipids: Roles in Cell Trafficking and Associated Inborn Errors DOI Creative Commons
Foudil Lamari, Francis Rossignol, Grant A. Mitchell

et al.

Journal of Inherited Metabolic Disease, Journal Year: 2025, Volume and Issue: 48(2)

Published: March 1, 2025

Language: Английский

Citations

0
Recent advances in degraders engaging lysosomal pathways and related nanomedicine DOI

Runxin Lu,

Xiaofeng Ni, Sha Diao

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 292, P. 117701 - 117701

Published: April 28, 2025

Language: Английский

Citations

0
EFM2BF: Extraction and fusion of multi-network multi-scale bio-topological features for gene prediction in brain diseases DOI
Zhuokun Tan, Longfei Luo, Jingjing Yang

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108509 - 108509

Published: June 1, 2025

Language: Английский

Citations

0
DDHD2 promotes lipid droplet catabolism by acting as a TAG lipase and a cargo receptor for lipophagy DOI
Kun Gao, Fei Jia, Yao Li

et al.

Autophagy, Journal Year: 2024, Volume and Issue: 20(10), P. 2346 - 2348

Published: June 23, 2024

Mutations in the DDHD2 (DDHD domain containing 2) gene cause autosomal recessive spastic paraplegia type 54 (SPG54), a rare neurodegenerative disorder characterized by early childhood onset of progressive paraplegia. is reported as principal brain triacylglycerol (TAG) lipase whose dysfunction causes massive lipid droplet (LD) accumulation brains SPG54 patients. However, precise functions regulating LD catabolism are not yet fully understood. In recent study, we demonstrate that interacts with multiple members Atg8-family proteins (MAP1LC3/LC3s, GABARAPs), which play crucial roles lipophagy. possesses two LC3-interacting region (LIR) motifs contribute to its LD-eliminating activity. Moreover, enhances colocalization between LC3B and LDs promote LD·ATTEC, compound tethers LC3 enhance their macroautophagic/autophagic clearance, effectively counteracts deficiency-induced accumulation. These findings provide insights into dual TAG cargo receptor for lipophagy neuronal catabolism, also suggest potential therapeutic approach treating

Language: Английский

Citations

1
Targeting selective autophagy in CNS disorders by small-molecule compounds DOI
Yanrong Zheng, Zhuchen Zhou, Mengting Liu

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 263, P. 108729 - 108729

Published: Oct. 12, 2024

Language: Английский

Citations

1
DDHD2 is involved in the malignant progression of early luminal A breast cancer by changing cell membrane proteins and immune responses functionality DOI Creative Commons
Yawen Song, Liantao Guo, Deguang Kong

et al.

Oncology and Translational Medicine, Journal Year: 2024, Volume and Issue: 10(5), P. 231 - 244

Published: Sept. 2, 2024

Abstract Background Luminal A breast cancer has the best prognosis of all malignant types. In clinical practice, some patients with luminal present small tumors (usually <20 mm) but lymph node metastases or even distant organ metastasis. Owing to their insensitivity chemotherapy and lack conclusive evidence, there is a significant gap in research on high invasiveness. This study aimed identify genes that drive invasiveness explore underlying mechanisms. Methods this study, we first utilized bioinformatics techniques analyze differentially expressed mRNAs enrich common functional pathways target gene DDHD domain containing 2 (DDHD2). We then evaluated association between DDHD2 expression patient prognosis, genetic material changes, transcriptional, translational, immune responses cancer. also conducted experiments at molecular cellular levels validate these biochemical Results The varied low-grade without metastases. Our findings demonstrated exerted carcinogenic effects through various by altering cell adhesion migration, regulating proliferation apoptosis cycles, suppressing responses. Moreover, pathway which inhibited immunity was preliminarily verified. Conclusions results revealed novel role for promoting transformation Considering its tumor microenvironment tumor-infiltrating cells epithelial-mesenchymal transition, proposed as reliable direction future immunotherapy potential resistance.

Language: Английский

Citations

0