The role of LncRNA-mediated autophagy in cancer progression DOI Creative Commons

Zi-Yuan Liu,

Jiaming Tang,

Meng-Qi Yang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 12, 2024

Long non-coding RNAs (lncRNAs) are a sort of transcripts that more than 200 nucleotides in length. In recent years, many studies have revealed the modulatory role lncRNAs cancer. Typically, linked to variety essential events, such as apoptosis, cellular proliferation, and invasion malignant cells. Simultaneously, autophagy, an intracellular degradation mechanism eukaryotic cells, is activated respond multiple stressful circumstances, for example, nutrient scarcity, accumulation abnormal proteins, organelle damage. Autophagy plays both suppressive promoting roles Increasingly, unveiled how dysregulated expression can disrupt autophagic balance, thereby contributing cancer progression. Consequently, exploring interplay between autophagy holds promising implications clinical research. this manuscript, we methodically compiled advances molecular mechanisms briefly summarized lncRNA-mediated axis.

Language: Английский

Long non-coding RNA CASC9 promotes gefitinib resistance in NSCLC by epigenetic repression of DUSP1 DOI Creative Commons
Zhenyao Chen, Qinnan Chen, Zhixiang Cheng

et al.

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(10)

Published: Oct. 14, 2020

Abstract Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, has greatly affected clinical outcomes in non-small cell lung cancer (NSCLC) patients. The long noncoding RNAs (lncRNAs) are known regulate tumorigenesis and progression, but their contributions NSCLC gefitinib resistance remain poorly understood. In this study, by analyzing the differentially expressed lncRNAs gefitinib-resistant cells gefitinib-sensitive National Institute of Health GEO dataset, we found that lncRNA CASC9 expression was upregulated, also verified resistant tissues. Gain loss function studies showed inhibition restored sensitivity both vitro vivo, whereas overexpression promoted resistance. Mechanistically, repressed tumor suppressor DUSP1 recruiting histone methyltransferase EZH2, thereby increasing gefitinib. Furthermore, ectopic increased inactivating ERK pathway. Our results highlight essential role resistance, suggesting CASC9/EZH2/DUSP1 axis might be a novel target for overcoming EGFR-TKI NSCLC.

Language: Английский

Citations

85
The Role of LncRNAs in Translation DOI Creative Commons
Didem Karakaş, Bülent Özpolat

Non-Coding RNA, Journal Year: 2021, Volume and Issue: 7(1), P. 16 - 16

Published: Feb. 20, 2021

Long non-coding RNAs (lncRNAs), a group of non-protein coding with lengths more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins regulate gene expression at the transcriptional, post-transcriptional, translational, post-translational levels. Depending on cellular location, lncRNAs are involved in wide range functions, including chromatin modification, transcriptional activation, interference, scaffolding regulation translational machinery. This review highlights recent studies protein translation modulating factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) signaling pathways this process as wells potential roles tumor suppressors or promoters.

Language: Английский

Citations

80
Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer DOI
Arnab Sarkar, Abhik Paul, Tanmoy Banerjee

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 944, P. 175588 - 175588

Published: Feb. 13, 2023

Language: Английский

Citations

29
Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway DOI

Huanyan Wu,

Linlin Qu, Xue Bai

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 186, P. 114587 - 114587

Published: March 8, 2024

Language: Английский

Citations

12
Current understanding of functional peptides encoded by lncRNA in cancer DOI Creative Commons
Hua Tian, Lu Tang, Zihan Yang

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 19, 2024

Abstract Dysregulated gene expression and imbalance of transcriptional regulation are typical features cancer. RNA always plays a key role in these processes. Human transcripts contain many RNAs without long open reading frames (ORF, > 100 aa) that more than 200 bp length. They usually regarded as non-coding (lncRNA) which play an important cancer regulation, including chromatin remodeling, translational miRNA sponges. With the advancement ribosome profiling sequencing technologies, increasing research evidence revealed some ORFs lncRNA can also encode peptides participate multiple organ tumors, undoubtedly opens new chapter field oncology research. In this review, we discuss biological function current methods to evaluate their coding potential functional small encoded by cancers. Investigating understanding regulatory mechanisms may contribute deeper development targeted anticancer therapies.

Language: Английский

Citations

12
An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer DOI Creative Commons
Jingsun Wei, Xiaoxu Ge, Yang Tang

et al.

Journal of Oncology, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 13

Published: Oct. 21, 2020

Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy closely related development treatment colorectal cancer, we investigated potential prognostic value long noncoding RNA (lncRNA) in cancer. In this study, acquired information on expression lncRNAs from Cancer Genome Atlas (TCGA) database found that 860 were autophagy-related genes. Subsequently, univariate Cox regression analysis was used investigate 32 linked colon eight (i.e., intergenic nonprotein coding 1503 [LINC01503], ZEB1 antisense 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, TNFRSF10A-AS1) selected through multivariate analysis. Based these lncRNAs, risk signature constructed, patients divided into high- low-risk groups. The high-risk group's overall survival time significantly shorter than group (p < 0.0001). Receiver operating characteristic curve performed further confirm validity model (area under curve: 0.689). Moreover, suggested score significant factor Gene set enrichment showed gene sets are enriched cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. has for These may play vital role biology

Language: Английский

Citations

52
Exploring the role of non-coding RNAs in autophagy DOI Open Access
Soudeh Ghafouri‐Fard, Hamed Shoorei,

Mahdi Mohaqiq

et al.

Autophagy, Journal Year: 2021, Volume and Issue: 18(5), P. 949 - 970

Published: Feb. 2, 2021

As a self-degradative mechanism, macroautophagy/autophagy has role in the maintenance of energy homeostasis during critical periods development cells. It also controls cellular damage through eradication damaged proteins and organelles. This process is accomplished by tens ATG (autophagy-related) proteins. Recent studies have shown involvement non-coding RNAs regulation autophagy. These transcripts mostly modulate expression genes. Both long (lncRNAs) microRNAs (miRNAs) been to autophagy mechanism. Levels several lncRNAs miRNAs are altered this process. In present review, we discuss diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia epilepsy.Abbreviations: AMI: infarction; ATG: autophagy-related; lncRNA: RNA; miRNA: microRNA.

Language: Английский

Citations

52
Circular RNA FNDC3B Protects Oral Squamous Cell Carcinoma Cells From Ferroptosis and Contributes to the Malignant Progression by Regulating miR-520d-5p/SLC7A11 Axis DOI Creative Commons
Jie Yang, Xinghua Cao,

Kefeng Luan

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Aug. 9, 2021

Oral squamous cell carcinoma (OSCC) is a common head and neck malignancy with increasing mortality high recurrence. Ferroptosis an emerging programed death plays essential role in tumorigenesis. Circular RNAs (circRNAs) have been reported as type of critical regulators OSCC development. In this study, we identified the function circular RNA FNDC3B (circFNDC3B) regulating ferroptosis during malignant progression OSCC. Our data demonstrated that silencing circFNDC3B by shRNA inhibited GPX4 SLC7A11 expression enhanced ROS, iron, Fe 2+ levels cells. CircFNDC3B knockdown reinforced erastin-induced inhibitory effect on The depletion repressed proliferation apoptosis Mechanically, was able to increase targeting miR-520d-5p. overexpression reversed or miR-520d-5p-induced phenotypes Moreover, tumorgenicity assays nude mice showed growth vivo . Taken together, concluded attenuated cells contributed miR-520d-5p/SLC7A11 axis. CircFNDC3B, miR-520d-5p, may serve potential therapeutic targets

Language: Английский

Citations

44
Role of PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers DOI Creative Commons
Soudeh Ghafouri‐Fard,

Ali Noie Alamdari,

Yashar Noee Alamdari

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Aug. 13, 2022

Abstract PI3K/AKT pathway is an important in the carcinogenesis since it has central impacts regulation of metabolic pathways, cell proliferation and survival, gene expression protein synthesis. This been reported to be dysregulated several types cancers. In current review, we summarize role this signaling squamous carcinomas (SCCs) originated from different parts body cervix, oral cavity, head neck skin. The data presented review shows impact dysregulation survival patients with SCC. Moreover, targeted therapies against have found effective reduction tumor burden both animal models clinical settings. Finally, a number molecules that regulate can used as diagnostic markers for SCCs.

Language: Английский

Citations

35
Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword DOI Creative Commons
Yunchao Zhang, Jiayu Tang, Cheng Wang

et al.

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 367 - 381

Published: June 16, 2023

The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate patients is still unsatisfactory. Therefore, it necessary to further elucidate molecular mechanisms involved in tumor development drug resistance improve cure or rates. In recent years, autophagy has become a hot topic field oncology research, which plays double-edged role tumorigenesis, progression, resistance. Meanwhile, long non-coding RNA (lncRNA) also been shown regulate autophagy, two-sided nature determines dual regulatory autophagy-related lncRNAs (ARlncRNAs). ARlncRNAs can be effective therapeutic targets for various cancers. Furthermore, high abundance stability tissues make them promising biomarkers. this review, we summarized roles cell proliferation, apoptosis, migration, invasion, resistance, angiogenesis, radiation immune regulation. addition, described clinical significance these ARlncRNAs, including as biomarkers/therapeutic their association with drugs.

Language: Английский

Citations

21