Macrophages in immunoregulation and therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 22, 2023

Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.

Language: Английский

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The CCL5/CCR5 Axis in Cancer Progression

Cancers, Journal Year: 2020, Volume and Issue: 12(7), P. 1765 - 1765

Published: July 2, 2020

Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C ligand 5/C-C receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5 its CCR5 have been found in hematological malignancies solid tumors. Numerous preclinical vitro vivo studies shown a key role CCL5/CCR5 cancer, thus provided rationale for clinical trials using repurposed drug maraviroc, antagonist used treat HIV/AIDS. This review summarizes current knowledge on cancer. First, it describes involvement cancer progression, including autocrine paracrine growth, ECM (extracellular matrix) remodeling migration, stem cell expansion, DNA damage repair, metabolic reprogramming, angiogenesis. Then, focuses individual tumors which studied preclinically. Finally, discusses strategies counteract different cancers maraviroc or therapeutic monoclonal antibodies.

Language: Английский

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CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7619 - 7619

Published: Oct. 15, 2020

CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal domain that play important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic eosinophils, macrophages, monocytes, NK well neoplasia. In this review, we discuss human motif chemokine ligands: CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, CCL28 (CC receptor CCR5, CCR6, CCR7, CCR8, CCR9, CCR10 ligands). We present their functioning physiology neoplasia, including the proliferation, apoptosis resistance, drug migration, invasion of cancer cells. significance receptors organ-specific metastasis, influence each on recruitment various cells to tumor niche, cancer-associated fibroblasts (CAF), Kupffer myeloid-derived suppressor (MDSC), osteoclasts, tumor-associated macrophages (TAM), tumor-infiltrating lymphocytes (TIL), regulatory T (Treg). Finally, show how effect vascular endothelial lymphatic leads angiogenesis lymphangiogenesis.

Language: Английский

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Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Feb. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Language: Английский

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Cancer Stemness Meets Immunity: From Mechanism to Therapy

Cell Reports, Journal Year: 2021, Volume and Issue: 34(1), P. 108597 - 108597

Published: Jan. 1, 2021

Cancer stem cells (CSCs) are self-renewing that facilitate tumor initiation, promote metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many types have revealed a prominent association between stemness immune signatures, potentially implying biological interaction such hallmark features of cancer. Emerging experimental evidence has substantiated the influence CSCs on cells, including tumor-associated macrophages, myeloid-derived suppressor T in microenvironment and, reciprocally, importance sustaining CSC its survival niche. This review covers cellular molecular mechanisms underlying symbiotic interactions how heterotypic signaling maintains tumor-promoting ecosystem informs therapeutic strategies intercepting this co-dependency.

Language: Английский

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Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Dec. 22, 2022

Cancer divergence has many facets other than being considered a genetic term. It is tremendous challenge to understand the metastasis and therapy response in cancer biology; however, it postulates opportunity explore possible mechanism surrounding tumor environment. Most deadly solid malignancies are distinctly characterized by their microenvironment (TME). TME consists of stromal components such as immune, inflammatory, endothelial, adipocytes, fibroblast cells. stem cells (CSCs) or stem-like small sub-set population within believed be responsible player self-renewal, metastasis, The correlation between CSCs remains an enigma understanding events resistance biology. Recent evidence suggests that dictates maintenance arbitrate progression metastasis. adipocyte, release growth factors, cytokines, chemokines, microRNAs, exosomes provide cues for gain CSC features. These intricate cross-talks fueled evolve into aggressive, invasive, migratory phenotypes development. In this review, we have abridged recent developments role factors how these influence transition further translate cancer.

Language: Английский

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STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

Pharmacological Research, Journal Year: 2022, Volume and Issue: 182, P. 106311 - 106311

Published: June 15, 2022

Language: Английский

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A second-generation M1-polarized CAR macrophage with antitumor efficacy

Nature Immunology, Journal Year: 2023, Volume and Issue: 25(1), P. 102 - 116

Published: Nov. 27, 2023

Language: Английский

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Exploiting innate immunity for cancer immunotherapy

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 27, 2023

Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.

Language: Английский

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Hallmarks of cancer stemness

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(5), P. 617 - 639

Published: May 1, 2024

Language: Английский

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