Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells DOI Creative Commons
Meenakshi Tiwari,

Pransu Srivastava,

Sabiya Abbas

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 447 - 447

Published: March 4, 2024

Tumors are composed of heterogeneous populations dysregulated cells that grow in specialized niches support their growth and maintain properties. Tumor heterogeneity metastasis among the major hindrances exist while treating cancer patients, leading to poor clinical outcomes. Although factors determine tumor complexity remain largely unknown, several genotypic phenotypic changes, including DNA mutations metabolic reprograming provide with a survival advantage over host resistance therapeutics. Furthermore, presence specific population within mass, commonly known as stem (CSCs), is thought initiate formation, maintenance, resistance, recurrence. Therefore, these CSCs have been investigated detail recently potential targets treat prevent Understanding molecular mechanisms involved CSC proliferation, self-renewal, dormancy may important clues for developing effective therapeutic strategies. Autophagy, catabolic process, has long recognized regulate various physiological pathological processes. In addition regulating cells, recent studies identified critical role autophagy functions. Autophagy activated under adverse conditions promotes cellular survival, even cell death. Thus, it intriguing address whether or inhibits functions modulation can be used functions, either alone combination. This review describes roles regulation proliferation quiescence CSCs, its during stress. The further highlights autophagy-associated pathways could CSCs. Overall, present will help rationalize translational approaches involve autophagy-mediated controlling progression, metastasis,

Language: Английский

The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy DOI
Peng Huang,

Feng Wen,

YiShan Li

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 344, P. 122576 - 122576

Published: March 14, 2024

Language: Английский

Citations

9
Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies DOI Creative Commons

Yunhan Tan,

Siyuan Qin, Zhe Zhang

et al.

MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 10, 2025

Abstract The success of cancer therapy has been significantly hampered by various mechanisms therapeutic resistance. Chief among these is the presence clonal heterogeneity within an individual tumor mass. introduction concept stem cells (CSCs)—a rare and immature subpopulation with tumorigenic potential that contributes to intratumoral heterogeneity—has deepened our understanding drug Given characteristics CSCs, such as increased drug‐efflux activity, enhanced DNA‐repair capacity, high metabolic plasticity, adaptability oxidative stress, and/or upregulated detoxifying aldehyde dehydrogenase (ALDH) enzymes, CSCs have recognized a theoretical reservoir for resistant diseases. Implicit in this recognition possibility CSC‐targeted strategies might offer breakthrough overcoming resistance patients. Herein, we summarize generation current underlying CSC‐mediated This extended knowledge progressively translated into novel anticancer enriched available options combination treatments, all which are anticipated improve clinical outcomes patients experiencing CSC‐related relapse.

Language: Английский

Citations

1
Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction DOI Creative Commons
Francesco Verona, Sebastiano Di Bella,

Roberto Schirano

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Cancer stem cells (CSCs) are a small subset within the tumor mass significantly contributing to cancer progression through dysregulation of various oncogenic pathways, driving growth, chemoresistance and metastasis formation. The aggressive behavior CSCs is guided by several intracellular signaling pathways such as WNT, NF-kappa-B, NOTCH, Hedgehog, JAK-STAT, PI3K/AKT1/MTOR, TGF/SMAD, PPAR MAPK kinases, well extracellular vesicles exosomes, molecules cytokines, chemokines, pro-angiogenetic growth factors, which finely regulate CSC phenotype. In this scenario, microenvironment (TME) key player in establishment permissive niche, where engage intricate communications with diverse immune cells. "oncogenic" mainly represented B T lymphocytes, NK cells, dendritic Among macrophages exhibit more plastic adaptable phenotype due their different subpopulations, characterized both immunosuppressive inflammatory phenotypes. Specifically, tumor-associated (TAMs) create an milieu production plethora paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting acquisition stem-like, invasive metastatic TAMs have demonstrated ability communicate via direct ligand/receptor (such CD90/CD11b, LSECtin/BTN3A3, EPHA4/Ephrin) interaction. On other hand, exhibited capacity influence creating favorable for progression. Interestingly, bidirectional TME leads epigenetic reprogramming sustains malignant transformation. Nowadays, integration biological computational data obtained cutting-edge technologies (single-cell RNA sequencing, spatial transcriptomics, trajectory analysis) has improved comprehension biunivocal multicellular dialogue, providing comprehensive view heterogeneity dynamics CSCs, uncovering alternative mechanisms evasion therapeutic resistance. Moreover, combination biology will lead development innovative target therapies dampening CSC-TME Here, we aim elucidate most recent insights on complex interactions specifically TAMs, tracing exhaustive scenario from primary

Language: Английский

Citations

1
Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics DOI
Subhadip Mukhopadhyay, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj

et al.

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 85, P. 196 - 208

Published: Sept. 6, 2021

Language: Английский

Citations

46
Intrinsic and Extrinsic Factors Impacting Cancer Stemness and Tumor Progression DOI Open Access

A. O. Ponomarev,

Zarema E. Gilazieva, Valeriya V. Solovyeva

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 970 - 970

Published: Feb. 15, 2022

Tumor heterogeneity represents an important limitation to the development of effective cancer therapies. The presence stem cells (CSCs) and their differentiation hierarchies contribute complexity confer tumors ability grow, resist treatment, survive unfavorable conditions, invade neighboring distant tissues. A large body research is currently focusing on understanding properties CSCs, including cellular molecular origin, as well biological behavior in different tumor types. In turn, this knowledge informs strategies for targeting these initiating related stemness. Cancer stemness modulated by microenvironment, which influences CSC function survival. Several advanced vitro models are being developed study order advance new key pathways involved self-renewal dormancy, mimic patients' pre-clinical drug testing. review, we discuss CSCs modulation factors signaling pathways. addition, introduce current that allow targeted

Language: Английский

Citations

33
Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance DOI Open Access
Xin Wang,

Jihye Lee,

Changqing Xie

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(2), P. 381 - 381

Published: Jan. 13, 2022

Cancer stem cells (CSCs) are a subset of the tumor population that play critical roles in tumorigenicity, metastasis, and relapse. A key feature CSCs is their resistance to numerous therapeutic strategies which include chemotherapy, radiation, immune checkpoint inhibitors. In recent years, there growing body literature suggests link between CSC maintenance autophagy, mechanism recycle intracellular components during moments environmental stress, especially since thrive microenvironment plagued with hypoxia, acidosis, lack nutrients. Autophagy activation has been shown aid upkeep stemness state along bolstering cancer treatment. However, studies have also suggested autophagy double-edged sword anti-tumorigenic properties under certain circumstances. This review summarizes integrates what published terms role plays more complex interplay apoptosis involves multiple pathways regulation. Future therapy needed eradicate this resistant cell through

Language: Английский

Citations

32
Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer DOI Creative Commons

Egle-Helene Ervin,

Rhiannon French,

Chao‐Hui Chang

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 87, P. 48 - 83

Published: Nov. 5, 2022

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of transcription factor expression and/or activity enables cancer cell to acquire a stem-like state characterised capacity self-renew, differentiate and form tumours in vivo. These cells are highly metastatic therapy resistant, thus warranting more complete understanding the molecular mechanisms downstream factors that mediate establishment stemness state. Here, we review recent research findings provide mechanistic link between commonly deregulated cancer. particular, describe role master (SOX, OCT4, NANOG, KLF, BRACHYURY, SALL, HOX, FOX RUNX), signalling-regulated (SMAD, β-catenin, YAP, TAZ, AP-1, NOTCH, STAT, GLI, ETS NF-κB) unclassified (c-MYC, HIF, EMT P53) across diverse tumour types, thereby yielding comprehensive overview identifying shared targets, highlighting unique discussing complexities.

Language: Английский

Citations

31
Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy DOI Creative Commons

Jing Ye,

Jin Zhang,

Yanghui Zhu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(12), P. 4688 - 4714

Published: Aug. 12, 2023

Beclin-1 is the firstly-identified mammalian protein of autophagy machinery, which functions as a molecular scaffold for assembly PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling induction and other cellular trafficking events. Notably, there mounting evidence establishing implications in diverse tumorigenesis processes, including tumor suppression progression well resistance to cancer therapeutics CSC (cancer stem-like cell) maintenance. More importantly, has been confirmed potential target treatment multiple cancers. In this review, we provide comprehensive survey structure, functions, regulations Beclin-1, discuss recent advances understanding controversial roles oncology. Moreover, focus on summarizing targeted Beclin-1-regulating strategies therapy, providing novel insights into promising strategy regulating improve future.

Language: Английский

Citations

22
Autophagy orchestrates resistance in hepatocellular carcinoma cells DOI Open Access

Homeyra Seydi,

Kosar Nouri,

Niloufar Rezaei

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114487 - 114487

Published: March 22, 2023

Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) HCC cells. In addition, many experiments report a remarkable crosstalk between treatment pathways. Thus, could be key factors enabling tumor cells to hinder induced cell death after medical interventions. Therefore, extensive research on molecular pathways involved induction been conducted achieve desired response. The related therapy are TGF-β, MAPK, NRF2, NF-κB, non-coding RNAs. EMT, drug transports, apoptosis evasion, DNA repair, cancer stem cells, hypoxia considerable impact hepatoma cell's response therapies. These mechanisms protect against various treatments shown each them connected HCC. Hence, inhibition may an effective strategy improve outcome patients. this review, we further highlight how leads poor during through complex network it enhances primary liver cancer. We propose combinational regimens approved protocols plus inhibitors overcome therapy.

Language: Английский

Citations

21
SOX2-associated signaling pathways regulate biological phenotypes of cancers DOI Open Access
Li Ding, Youlin Yu, Chao Ma

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114336 - 114336

Published: Feb. 2, 2023

SOX2 is a transcription factor involved in multiple stages of embryonic development. In related reports, was found to be abnormally expressed tumor tissues and correlated with clinical features such as TNM staging, grade, prognosis patients various cancer types. most types, tumor-promoting that regulates progression metastasis primarily by maintaining the stemness cells. addition, also proliferation, apoptosis, invasion, migration, ferroptosis drug resistance However, acts suppressor some cases certain gastric lung cancer. These key regulatory functions involve complex networks, including protein-protein protein-nucleic acid interactions through signaling pathways noncoding RNA interactions, modulating expression may potential therapeutic strategy for patients. Therefore, we sorted out phenotypes cancer, hoping provide basis further translation.

Language: Английский

Citations

18