Li–Fraumeni Syndrome: Mutation of TP53 Is a Biomarker of Hereditary Predisposition to Tumor: New Insights and Advances in the Treatment DOI Open Access
Valentina Rocca, Giovanni Blandino,

Lucia D’Antona

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(15), P. 3664 - 3664

Published: July 27, 2022

Li–Fraumeni syndrome (LFS) is a rare familial tumor predisposition with autosomal dominant inheritance, involving germline mutations of the TP53 suppressor gene. The most frequent tumors that arise in patients under age 45 are osteosarcomas, soft-tissue sarcomas, breast young women, leukemias/lymphomas, brain tumors, and adrenal cortex. To date, no other gene have been associated LFS. diagnosis usually confirmed by genetic testing for identification mutations; therefore, these considered biomarkers spectrum Here, we aim to review novel molecular mechanisms involved oncogenic functions mutant p53 LFS discuss recent new diagnostic therapeutic approaches exploiting as druggable targets.

Language: Английский

Non-coding RNAs in disease: from mechanisms to therapeutics DOI
Kinga Németh, Recep Bayraktar, Manuela Ferracin

et al.

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(3), P. 211 - 232

Published: Nov. 15, 2023

Language: Английский

Citations

361
Regulatory mechanisms of PD-1/PD-L1 in cancers DOI Creative Commons
Xin Lin,

Kuan Kang,

Pan Chen

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 18, 2024

Abstract Immune evasion contributes to cancer growth and progression. Cancer cells have the ability activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) cell ligands (PD-Ls) are considered be major molecules. interaction of PD-1 PD-L1 negatively regulates adaptive response mainly by inhibiting activity effector T while enhancing function regulatory (Tregs), largely contributing maintenance homeostasis prevents dysregulated immunity harmful responses. However, exploit PD-1/PD-L1 axis cause escape in development Blockade neutralizing antibodies restores enhances anti-tumor immunity, achieving remarkable success therapy. Therefore, mechanisms cancers attracted an increasing attention. This article aims provide a comprehensive review roles signaling human autoimmune diseases cancers. We summarize all aspects underlying expression cancers, including genetic, epigenetic, post-transcriptional post-translational mechanisms. In addition, we further progress clinical research on antitumor effects targeting alone combination with other therapeutic approaches, providing new strategies for finding tumor markers developing combined approaches.

Language: Английский

Citations

133
Non-coding RNAs and ferroptosis: potential implications for cancer therapy DOI Creative Commons
Amar Balihodzic, Felix Prinz, Michael A. Dengler

et al.

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 29(6), P. 1094 - 1106

Published: April 14, 2022

Abstract Ferroptosis is a recently defined form of regulated cell death, which biochemically and morphologically distinct from traditional forms programmed death such as apoptosis or necrosis. It driven by iron, reactive oxygen species, phospholipids that are oxidatively damaged, ultimately resulting in mitochondrial damage breakdown membrane integrity. Numerous cellular signaling pathways molecules involved the regulation ferroptosis, including enzymes control redox status. Alterations ferroptosis-regulating network can contribute to development various diseases, cancer. Evidence suggests ferroptosis commonly suppressed cancer cells, allowing them survive progress. However, cells resistant common chemotherapeutic drugs seem be highly susceptible inducers, highlighting great potential pharmacologic modulation for treatment. Non-coding RNAs (ncRNAs) considered master regulators processes, particularly where they have been implicated all hallmarks Recent work also demonstrated their involvement molecular ferroptosis. Hence, ncRNA-based therapeutics represent an exciting alternative modulate therapy. This review summarizes ncRNAs highlights underlying mechanisms light therapeutic applications.

Language: Английский

Citations

98
Small extracellular vesicles (sEVs) in pancreatic cancer progression and diagnosis DOI

Reaid Hasan,

Zhen Zhao, Yuanke Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 269 - 282

Published: Feb. 6, 2025

Language: Английский

Citations

2
Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering DOI Creative Commons
Mohit J. Mehta,

Dongjun Shin,

Hyun Sung Park

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Exosomes have emerged as versatile biomolecules in gastrointestinal (GI) cancer management, leveraging their inherent cargo‐carrying capabilities to overcome the limitations of current diagnostic and therapeutic strategies. This review provides a comprehensive exploration exosome‐based technologies, highlighting dual roles biomarkers vehicles. On front, this investigates specific exosomal biomarkers—including miRNAs, lncRNAs, circRNAs, proteins—emphasizing tumor biology clinical utility, such accuracy, early detection potential, prognostic significance. Therapeutically, study examines sources, purification methodologies, engineering strategies that enhance efficacy exosomes modulating immune responses, overcoming drug resistance, suppressing metastasis. By providing overview field, serves guideline for researchers clinicians entering offering novel insights into potential theranostic systems delineating future directions existing challenges.

Language: Английский

Citations

2
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention DOI
Yacoubou Abdoul Razak Mahaman, Kidane Siele Embaye, Huang Fang

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 74, P. 101544 - 101544

Published: Dec. 18, 2021

Language: Английский

Citations

102
Exosomal RNAs: Novel Potential Biomarkers for Diseases—A Review DOI Open Access
Jian Wang, Binglin Yue, Yongzhen Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2461 - 2461

Published: Feb. 23, 2022

Exosomes are a subset of nano-sized extracellular vesicles originating from endosomes. mediate cell-to-cell communication with their cargos, which includes mRNAs, miRNAs, lncRNAs, and circRNAs. Exosomal RNAs have cell specificity reflect the conditions donor cells. Notably, detection in biofluids can be used as diagnostic marker for various diseases. ideal biomarkers because surrounding membranes confer stability they detectable almost all biofluids, helps to reduce trauma avoid invasive examinations. However, knowledge exosomal remains scarce. The present review summarizes biogenesis, secretion, uptake exosomes, current researches exploring circRNAs potential diagnosis human diseases, well recent techniques exosome isolation.

Language: Английский

Citations

56
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation DOI Creative Commons
Xuehui Wang, Wei Jian, Qifeng Luo

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(9)

Published: Sept. 17, 2022

Abstract PI3K/AKT signaling pathway plays an important role in regulating the tumorigenesis, recurrence, and metastasis of breast cancer (BC). In this study, we discovered a circRNA with protein-coding potential, which named circSEMA4B. CircSEMA4B could encode novel protein, SEMA4B-211aa. Both circSEMA4B SEMA4B-211aa were remarkably downregulated BC tissues cell lines. Low expression was positively associated TNM stage, tumor size, lymph node metastasis, distant patients. The functional investigation showed that significantly inhibit proliferation migration vivo vitro. Of note, inhibited generation PIP3 by binding to p85, thereby inhibiting phosphorylation AKT (Thr308). (Ser473) through miR-330-3p/PDCD4 axis. Taken together, is negative regulator pathway, providing mechanistic insights into underlying mechanisms BC.

Language: Английский

Citations

49
Non-Melanoma Skin Cancer: A Genetic Update and Future Perspectives DOI Open Access
Marianela Zambrano‐Román, Jorge Ramón Padilla‐Gutiérrez, Yeminia Valle

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(10), P. 2371 - 2371

Published: May 11, 2022

Skin cancer is one of the main types worldwide, and non-melanoma skin (NMSC) most frequent within this group. Basal cell carcinoma (BCC) squamous (SCC) are common types. Multifactorial features well-known for development, new hallmarks gaining relevance. Genetics epigenetic regulation play an essential role in susceptibility progression, as well variety cells molecules that interact tumor microenvironment. In review, we provide update on genetic NMSC, candidate genes, therapies, considering diverse perspectives carcinogenesis. The global health situation pandemic have been challenging care systems, especially diagnosis treatment patients with cancer. We innovative approaches to overcome difficulties current clinical dynamics.

Language: Английский

Citations

47
CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis DOI Creative Commons
Asif Ahmad Bhat, Gaurav Gupta, Rajiv Dahiya

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 277 - 287

Published: Jan. 26, 2024

The intricate molecular landscape of cancer pathogenesis continues to captivate researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the dynamic regulation biological functions. study investigates elusive link between circRNAs and Transforming Growth Factor-β (TGF-β) signalling pathway, exploring their collective influence on progression metastasis. Our comprehensive investigation begins by profiling circRNA expression patterns diverse types, revealing a repertoire intricately linked TGF-β pathway. Through integrated bioinformatics analyses functional experiments, we elucidate specific circRNA-mRNA interactions that modulate signalling, unveiling regulatory controls governing this crucial Furthermore, provide compelling evidence impact circRNA-mediated modulation key cellular processes, including epithelial-mesenchymal transition (EMT), migration, cell proliferation. In addition mechanistic roles, have shown promise diagnostic prognostic biomarkers, well potential targets for therapy. Their ability critical pathways, such axis, underscores significance biology clinical applications. interplay is dissected, uncovering novel circuits contribute complexity biology. This review unravels previously unexplored dimension carcinogenesis, emphasizing role shaping landscape.

Language: Английский

Citations

16