Wnt signaling pathway: A comprehensive review

Cell Biology International, Journal Year: 2022, Volume and Issue: 46(6), P. 863 - 877

Published: March 17, 2022

Abstract Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it highly critical for a variety of physiological processes organism's body, including stem cell regeneration, proliferation, division, migration, polarity cell, determining fate the specification neural crest, symmetry morphogenesis. Wnts are extracellular secreted glycol proteins, consisted family 19 human proteins that represent complex nature regulatory structure efficiency signaling. Moreover, Wnt/β‐catenin‐dependent pathway β‐catenin‐independent further classified into Planar Cell Polarity Wnt/Ca 2+ pathways have been established as key nodes downstream frizzled (Fz/Fzd) receptor, these extensively analyzed at biochemical molecular levels. Genetic epigenetic activities ultimately characterize its subsequent responses contribute to Wnt‐β‐catenin hypo or hyper‐activation associated with disorders progression most significantly cancers. Recognizing how this operates crucial advancement cancer prevention therapies regenerative medicine methods.

Language: Английский

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Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 67, P. 100937 - 100937

Published: Feb. 2, 2023

Language: Английский

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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 114 - 114

Published: Jan. 20, 2025

Oxidative stress is a state of imbalance between the production reactive oxygen species (ROS) and nitrogen (RNS) antioxidant defence system in body. may be associated with variety diseases, such as ovarian cancer, diabetes mellitus, neurodegeneration. The generation oxidative one common refractory malignancies among gynaecological tumours, several factors. On hand, increased metabolism cancer cells can lead to ROS, on other impaired not able effectively scavenge excessive ROS. In addition, chemotherapy radiotherapy elevate cells. cause damage, promote development even result drug resistance. Therefore, studying important for prevention treatment cancer. Antioxidants, markers stress, might serve strategies preventing treating this review, we will discuss complex relationship well role therapeutic potential antioxidants thus guiding future research clinical interventions.

Language: Английский

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Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer

Journal for ImmunoTherapy of Cancer, Journal Year: 2022, Volume and Issue: 10(9), P. e004219 - e004219

Published: Sept. 1, 2022

Background Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells CRC TME and play a vital role progression metastasis. Most studies have focused on investigating of cell-specific progression, while contribution TAMs-specific still unknown. Here, we sought to investigate expression pattern TAMs its immunity progression. Methods patterns paratumor or adjacent normal tissue were analyzed 50 patients with using flow cytometry 141 immunohistochemistry. The correlation level M1 M2 phenotypic transition was analyzed. macrophage-specific response investigated vitro vivo. We further effect regulation macrophages. Results from clinical samples showed robustly higher than tissues. at III/IV stages compared I/II negatively associated survival CRC. + an phenotype interleukin (IL)-10 transforming growth factor (TGF)-β. promoted cell migration, invasion, supporting findings analysis. This mainly regulated by TGF-β-induced STAT3 activation-mediated release matrix metalloproteinases (MMP)2 MMP9 cells. –⁄– bone marrow transplantation wild-type mice, as well CD155– treatment, antitumor mice ectopic model. Additionally, released IL-4 trigger indicating regulatory development TAMs. Conclusions These indicated that responsible for M2-phenotype transition, immunosuppression, specific localization could turn into potential therapeutic target treatment.

Language: Английский

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Cancer chemoresistance and its mechanisms: Associated molecular factors and its regulatory role

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(9)

Published: Aug. 7, 2023

Language: Английский

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Biological functions and molecular interactions of Wnt/β-catenin in breast cancer: Revisiting signaling networks

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 232, P. 123377 - 123377

Published: Jan. 23, 2023

Language: Английский

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Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

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Extracellular Vesicle–Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis

Cancer Immunology Research, Journal Year: 2022, Volume and Issue: 11(2), P. 199 - 216

Published: Dec. 13, 2022

Ovarian cancer is one of the most common gynecologic malignancies with a highly immunosuppressive tumor microenvironment (TME) and poor prognosis. Circular RNA (circRNA) type noncoding high stability, which has been shown to play an important role in biological processes TME reprogramming variety tumors. The function novel circRNA, circATP2B4, epithelial ovarian (EOC) was detected evaluated. Transmission electron microscopy, differential ultracentrifugation qRT-PCR were used verify existence extracellular vesicles (EV)-packaged circATP2B4. Macrophage uptake circATP2B4 determined by EVs tracing. Dual luciferase reporter, FISH, Western blotting, flow cytometry assays investigate interactions between miR-532-3p as well sterol regulatory element-binding factor 1 (SREBF1) expression macrophages. CircATP2B4 upregulated EOC tissues positively correlated progression. Functionally, promoted carcinogenic progression metastasis both vitro vivo. Mechanistically, EV-packaged could be transmitted infiltrated macrophages acted competing endogenous relieve repressive effect on its target SREBF1. Furthermore, induced macrophage M2 polarization regulating miR-532-3p/SREBF1/PI3Kα/AKT axis, thereby leading immunosuppression metastasis. Collectively, these data indicate that circATP2B4-containing generated cells malignant behaviors cells. Thus, targeting EVs-packaged may provide potential diagnosis treatment strategy for cancer.

Language: Английский

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Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection

Advanced Science, Journal Year: 2023, Volume and Issue: 10(27)

Published: July 23, 2023

Detecting early cancer through liquid biopsy is challenging due to the lack of specific biomarkers for lesions and potentially low levels these markers. The current study systematically develops an extracellular-vesicle (EV)-based test detection, specifically focusing on high-grade serous ovarian carcinoma (HGSOC). marker selection based emerging insights into HGSOC pathogenesis, notably that it arises from precursor within fallopian tube. This work thus establishes murine tube (mFT) cells with oncogenic mutations performs proteomic analyses mFT-derived EVs. identified markers are then evaluated orthotopic animal model. In serially-drawn blood tumor-bearing mice, mFT-EV increase tumor initiation, supporting their potential use in detection. A pilot clinical (n = 51) further narrows EV five candidates, EpCAM, CD24, VCAN, HE4, TNC. combined expression distinguishes non-cancer 89% sensitivity 93% specificity. same also effective classifying three groups (non-cancer, early-stage HGSOC, late-stage HGSOC). developed approach, first time inaugurated tube-derived EVs, could be a minimally invasive tool monitor women at high risk timely intervention.

Language: Английский

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Exploiting Albumin as a Versatile Carrier for Cancer Theranostics

Accounts of Chemical Research, Journal Year: 2023, Volume and Issue: 56(18), P. 2403 - 2415

Published: Aug. 25, 2023

Conspectus"Theranostics" is a portmanteau that links the fields of therapeutics and diagnostics; it describes personalized medical approach with expectation to improve prognosis for cancer patients while reducing risk adverse effects currently commonly seen many systemic therapies. Theranostic radioligands can deliver radionuclides tumors in targeted manner, achieving both diagnosis irreversible damage tumor cells. Compared chemotherapy, therapeutic radioligand directly damages DNA sequence cells less likely be impacted by chemotherapy resistance, making use promising treatment modality. However, novel do not have optimal pharmacokinetics are rapidly cleared out body. Therefore, there has been long-standing interest development long-acting formulas prolonged circulation half-life.Albumin, as most abundant protein human serum, plays pivotal role physiological carrier of, e.g., fatty acids hormones. Its attributes, including extended time, biodegradability, nontoxicity, absence immunogenicity, render an exceptional candidate various drugs theranostic agents. In this regard, three prominent albumin-based drug delivery technologies developed: (1) coupling small molecule exogenous or endogenous albumin, (2) employing fusion technology conjugate bioactive proteins (3) encapsulating within albumin nanoparticles. Of these technologies, strategy binding molecules stands one widely applied approaches due its minimal high efficiency prolonging blood retention time. The utilization holds significant promise precision medicine diagnostic procedures.In Account, we describe recent radioligands. First, give brief introduction therapy advantages current challenges, such fast clearance. Subsequently, briefly summarize time focus on strategy. We also comprehensively review structure serum binders, efforts discovering new binders utilized developing Furthermore, progress PSMA-targeting radioligands, summarizing relevant structure–activity relationships (SARs). Lastly, outline probable issues future Collectively, SARs from our studies could shed light different

Language: Английский

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