L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling DOI Creative Commons
Wenjing Jin, Ling Su, Hong You

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

Abstract Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and attentions reversing drug resistance. However, its lung chemoresistance still unknown. To investigate effects L-Theanine on explore underlying mechanism cancer, we performed panel experiments vitro combined with RNA-seq analysis demonstrated improved to cisplatin (cis-diamminedichloroplatinum; DDP) inhibited stemness DDP-resistant but not non-resistant STAT3/NOTCH1 signaling was potential dominant process involved improving cancer. Mechanistically, impedes migration activation via regulating expression STAT3/NOTCH1/BMAL1 signaling-induced markers, reducing proliferation as well inhibiting resistance-related genes cells. In addition, combination Stat3 blockade synergistically summary, chemoresistant through signaling, finally The finding might provide research evidence for therapeutic options

Language: Английский

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies DOI Creative Commons

Qingmiao Shi,

Chen Xue,

Yifan Zeng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 27, 2024

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The receptor ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically necessitating receptor-ligand interaction to initiate classical signaling transduction. Accumulating evidence indicates that the pathway serves as both an oncogenic factor a tumor suppressor various cancer types. Dysregulation of this promotes epithelial-mesenchymal transition angiogenesis malignancies, closely linked proliferation, invasion, metastasis. Furthermore, contributes maintaining stem-like properties cells, thereby enhancing invasiveness. regulatory metabolic reprogramming microenvironment suggests pivotal involvement balancing suppressive effects. Moreover, implicated conferring chemoresistance cells. Therefore, comprehensive understanding these biological processes crucial developing innovative therapeutic strategies targeting signaling. This review focuses on research progress cancers, providing in-depth insights into potential mechanisms regulation occurrence progression cancer. Additionally, summarizes pharmaceutical clinical trials therapy, aiming offer new human malignancies.

Language: Английский

Citations

84
Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review DOI Open Access

Bethsebie Lalduhsaki Sailo,

Le Liu,

Suravi Chauhan

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 244 - 244

Published: Jan. 5, 2024

Recent advances in oncological research have highlighted the potential of naturally derived compounds cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli cabbage, has exhibited potent chemosensitizing capabilities across diverse types bone, brain, breast, lung, skin, etc. Chemosensitization refers to enhancement cell sensitivity chemotherapy agents, counteracting chemoresistance often developed by tumor cells. Mechanistically, SFN orchestrates this sensitization modulating array cellular signaling pathways (e.g., Akt/mTOR, NF-κB, Wnt/β-catenin), regulating expression activity pivotal genes, proteins, enzymes p53, p21, survivin, Bcl-2, caspases). When combined with conventional chemotherapeutic synergistically inhibits proliferation, invasion, migration, metastasis while potentiating drug-induced apoptosis. This positions as a adjunct therapy augment efficacy standard treatments. Ongoing preclinical clinical investigations aim further delineate therapeutic oncology. review illuminates multifaceted role phytochemical, emphasizing its enhance anti-cancer suggesting prospective contributions chemosensitization management.

Language: Английский

Citations

13
Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis DOI Creative Commons

Lemy Vanessa Barba-Rosado,

Domingo César Carrascal-Hernández, Daniel Insuasty

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(2), P. 186 - 186

Published: Jan. 13, 2024

Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer bone cancer, such as osteosarcoma and Ewing tumors, which occur frequently infants. This study shows an active interest the use graphene oxide its derivatives therapy against cancer. We present systematic review analyzing current state art related to GO treating osteosarcoma, through evaluating existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications were reviewed, has revealed that there excellent trend toward nanomaterials, based their thermal anti-cancer activities, treatment various therapeutic approaches. However, research needed develop highly efficient localized therapies. It suggested, therefore, photodynamic therapy, photothermal nanocarriers should be considered non-invasive, specific, alternatives osteosarcoma. These options promising approaches enhance effectiveness while also seeking reduce side effects minimize damage surrounding healthy tissues. The bibliometric analysis photochemical treatments reduced from January 2004 December 2022 extracted 948 documents with search strategy, mainly papers, conference demonstrating high-impact field supported by need selective central countries leading are United States, Iran, Italy, Germany, China, South Korea, Australia, strong collaborations At same time, most-cited papers published journals impact factors 6.0 (2021), 290 citations. Additionally, most topic high factor journals, according performed, field.

Language: Английский

Citations

6
lncRNAs: New players of cancer drug resistance via targeting ABC transporters DOI

Mohammad Ebrahimnezhad,

Sanaz Hassanzadeh Asl,

Maede Rezaie

et al.

IUBMB Life, Journal Year: 2024, Volume and Issue: 76(11), P. 883 - 921

Published: Aug. 1, 2024

Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily driven by the activity of ATP-binding cassette (ABC) transporters, which actively efflux chemotherapeutic agents from cancer cells, reducing their intracellular concentrations and therapeutic efficacy. Recent studies have highlighted pivotal role long noncoding RNAs (lncRNAs) in regulating this resistance, positioning them as crucial modulators ABC transporter function. lncRNAs, once considered transcriptional noise, are now recognized for complex regulatory capabilities at various cellular levels, including chromatin modification, transcription, post-transcriptional processing. This review synthesizes current research demonstrating how lncRNAs influence modulating expression transporters. can act molecular sponges, sequestering microRNAs that would otherwise downregulate genes. Additionally, they alter epigenetic landscape these genes, affecting activity. Mechanistic insights reveal contribute thereby altering drugs promoting resistance. Understanding interactions provides new perspective on basis chemoresistance, emphasizing network knowledge not only deepens our understanding biological mechanisms underlying but also suggests novel strategies. In conclusion, intricate interplay between transporters is developing innovative solutions combat underscoring importance continued field.

Language: Английский

Citations

6
LINC01089 in cancer: multifunctional roles and therapeutic implications DOI Creative Commons

Qiang Yi,

Gangfeng Zhu,

Xinting Ouyang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

Citations

5
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control DOI
Xianzhe Huang, Wenwei Chen, Yanyan Wang

et al.

Frontiers of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

0
Spectral Properties and Anticancer Activity of Novel Cisplatin-BODIPY Conjugates DOI
Ksenia V. Ksenofontova, Alexander A. Ksenofontov,

Anastasia A. Kerner

et al.

Optical Materials, Journal Year: 2025, Volume and Issue: unknown, P. 116680 - 116680

Published: Jan. 1, 2025

Language: Английский

Citations

0
An Investigation of the Anticancer Mechanism of Caesalpinia sappan L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Validation DOI Creative Commons

Mibae Jeong,

Jaemoo Chun, Sang‐Min Park

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 263 - 263

Published: Jan. 18, 2025

Caesalpinia sappan L. has exhibited various pharmacological effects, yet its anticancer activities against colorectal cancer (CRC) and underlying molecular mechanisms remain unclear. This study investigated the properties of an ethanol extract C. (CSE) CRC cells, focusing on identification bioactive compounds their action. A network pharmacology analysis was conducted to identify potential targets CSE, using LC-MS for compound identification. The effects CSE were then validated through in vitro vivo models CRC. approach identified 87 overlapping genes between CRC-related genes, with protein–protein interaction highlighting 33 key target genes. inhibited cell proliferation human lines, including HCT 116, KM12SM, HT-29, COLO 205, induced apoptosis via caspase 3/7 activation. Western blot analyses confirmed modulation critical signaling pathways, STAT3, AKT, mitogen-activated protein kinases. Furthermore, significantly suppressed tumor growth MC38 CRC-bearing mice. These findings suggest that possesses substantial as a natural agent treatment, need further exploration therapeutic development.

Language: Английский

Citations

0
Prognostic and clinicopathological roles of circular RNA expression in chemoresistance in head and neck squamous cell carcinoma: a systematic review DOI Creative Commons
Sayan Kumar Das, Sameer Khasbage, Abhishek Mishra

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Background Characterized by a poor prognosis and survivability, head neck squamous cell carcinoma (HNSCC) is an aggressive neoplastic condition with propensity for recurrence where the development of chemoresistance adversely affects prognostic outcome. Recently, it was shown that circular RNAs (circRNAs) augment cellular survivability malignant cells. Hence, biomarkers early detection in these patients can significantly aid preventing Objective The present study aimed to systematically identify circRNAs play vital role HNSCC understand their mechanisms action chemoresistance. Methods protocol prospectively registered on PROSPERO no. CRD42024532291. A six-stage methodological PRISMA recommendations were followed review. Results Discussion 13 studies identified which yielded have been investigated HNSCC. Of these, 11 reported be upregulated while only 2 found downregulated. Moreover, we modulate autophagy (circPARD3, circPKD2, circAP1M2 circPGAM1), apoptosis (circ-ILF2, circANKS1B, circTPST2, circPUM1 circ_0001971), drug efflux has_circ_0005033 circTPST2), EMT (circANKS1B, circCRIM1, tumor microenvironment (circ-ILF2. circ-ILF2, circCRIM1 DNA damage (circTPST2) potential (hsa_circ_0000190 hg19_ circ_0005033). Conclusion may serve as well response chemotherapy Systematic Review Registration , identifier

Language: Английский

Citations

0
Apelin/APJ: Another Player in the Cancer Biology Network DOI Open Access

Laura Naldi,

Alessandro Peri,

Benedetta Fibbi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2986 - 2986

Published: March 25, 2025

The apelinergic system exerts multiple biological activities in human pathologies, including cancer. Overactivation of apelin/APJ, which has been detected many malignant tumors, and the strong correlation with progression-free overall survival, suggested role an oncogene for apelin gene. Emerging evidence sheds new light on effects cellular functions homeostasis cancer cells supports a direct this pathway different hallmarks cancer: "sustaining proliferative signaling", "resisting cell death", "activating invasion metastasis", "inducing/accessing vasculature", "reprogramming metabolism", "avoiding immune destruction" "tumor-promoting inflammation", "enabling replicative immortality". This article reviews currently available literature intracellular processes regulated by focusing those pathways correlated tumor development progression. Furthermore, association between activity axis resistance to oncologic treatments (chemotherapy, immunotherapy, radiation) suggests apelin/APJ as possible target potentiate traditional therapies, well develop diagnostic prognostic applications. issue will be also covered review.

Language: Английский

Citations

0