Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

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Enhancing Fractionated Cancer Therapy: A Triple-Anthracene Photosensitizer Unleashes Long-Persistent Photodynamic and Luminous Efficacy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(9), P. 6252 - 6265

Published: Feb. 20, 2024

Conventional photodynamic therapy (PDT) is often limited in treating solid tumors due to hypoxic conditions that impede the generation of reactive oxygen species (ROS), which are critical for therapeutic efficacy. To address this issue, a fractionated PDT protocol has been suggested, wherein light irradiation administered stages separated by dark intervals permit recovery during these breaks. However, current photosensitizers used incapable sustaining ROS production intervals, leading suboptimal outcomes (Table S1). circumvent drawback, we have synthesized novel photosensitizer based on triple-anthracene derivative designed prolonged generation, even after cessation exposure. Our study reveals unique action derivatives, facilitating direct and effective disruption biomolecules significantly improving efficacy S2). Moreover, existing lack imaging capabilities monitoring, constraints fine-tuning parameters also serves as an afterglow agent, emitting sustained luminescence postirradiation. This function allows precise optimization between sessions aids determining timing subsequent irradiation, thus enabling meticulous control over parameters. Utilizing our photosensitizer, formulated regimen effectively eliminates orthotopic pancreatic tumors. investigation highlights promise employing long-persistent activity advanced approaches overcome limitations tumor treatment.

Language: Английский

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Bienzyme-Locked Activatable Fluorescent Probes for Specific Imaging of Tumor-Associated Mast Cells

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(18), P. 12656 - 12663

Published: April 29, 2024

Tumor-associated mast cells (TAMCs) have been recently revealed to play a multifaceted role in the tumor microenvironment. Noninvasive optical imaging of TAMCs is thus highly desired gain insights into their functions cancer immunotherapy. However, due lack single enzyme that specific cells, common probe design approach based on single-enzyme activation not applicable. Herein, we reported bienzyme-locked molecular (THCMC) photoinduced electron transfer-intramolecular charge-transfer hybrid strategy for vivo TAMCs. The mechanism ensures THCMC exclusively turns near-infrared (NIR) fluorescence only presence both tryptase and chymase specifically coexpressed by cells. Thus, effectively distinguishes from other leukocytes, including T neutrophils, macrophages, capability lacking single-locked probes. Such high specificity allows noninvasive tracking fluctuation living mice during results reveal decreased intratumoral signal after combination immunotherapy correlates well with reduced population TAMCs, accurately predicting inhibition growth. this study presents first NIR fluorescent but also proposes generic cell imaging.

Language: Английский

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Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: June 22, 2024

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.

Language: Английский

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Supramolecular systems for bioapplications: recent research progress in China

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

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Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786

Published: March 20, 2024

Language: Английский

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A Renal Clearable Nano‐Assembly with Förster Resonance Energy Transfer Amplified Superoxide Radical and Heat Generation to Overcome Hypoxia Resistance in Phototherapeutics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(44)

Published: June 28, 2024

Abstract Given that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct PSs is crucially important, but remains challenge. Herein, we present smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism develop photodynamic therapy (PDT) agent with encouraging amplification effect for accurate tumor therapy. Of note, benefiting from FRET effect, obtained nanostructured PDT (NanoPcSZ) boosted light‐harvesting ability not only amplifies superoxide radical (O 2 •‐ ) production also promotes heat generation upon near‐infrared light irradiation. These features facilitate NanoPcSZ realize excellent phototherapeutic response under both normal and environments. As result, in vitro vivo experiments achieved remarkable improvement therapeutic efficacy via combined of photothermal action photoreaction. Notably, can be eliminated organs (including liver, lung, spleen, kidney) apart site excreted through urine within 24 h its systemic administration. In this way, potential biotoxicity drug accumulation avoided biosafety further enhanced.

Language: Английский

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Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics complex biological systems due to its advantages of less background interference, high tissue penetration depth, contrast, and sensitivity. However, traditional NIR‐II imaging, which is characterized by “always on” or “turn mode, lacks ability quantitative detection, leading low reproducibility reliability during bio‐detection. In ratiometric can realize reliable analysis detection vivo providing reference signals correction, generating new opportunities prospects bioimaging biosensing. this review, current design strategies sensing mechanisms probes biosensing applications are systematically summarized. Further, challenges, future perspectives designing also discussed. It hoped that review provide effective guidance promote adoption vivo.

Language: Английский

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12234 - 12257

Published: Jan. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Language: Английский

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