APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(11-12), P. 1914 - 1943
Published: July 15, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(12), P. 3955 - 3972
Published: Jan. 1, 2023
This review highlights recent advances in the utilization of various endogenous and exogenous stimuli to activate nanocarrier-based ferroptosis cancer therapy that can be effective treating conventional drug-resistant tumors.
Language: Английский
Citations
124
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)
Published: July 24, 2023
Abstract Ferroptosis is a recently discovered essential type of cell death that mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests ferroptosis double-edged sword in human cancer. However, the precise underlying molecular mechanisms their differential roles tumorigenesis are unclear. Therefore, this review, we summarize briefly present key pathways ferroptosis, paying special attention to regulation as well its dual role an oncogenic tumor suppressor event various cancers. Moreover, multiple pharmacological activators summarized, prospect targeting cancer therapy further elucidated.
Language: Английский
Citations
110
International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(4), P. 1192 - 1210
Published: Jan. 1, 2023
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing incidence cisplatin-induced acute kidney injury. Mitophagy a type mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferroptosis, new modality programmed cell death, characterized by iron-dependent phospholipid peroxidation oxidative membrane damage. However, role mitophagy ferroptosis disease unclear. Here, we investigated underlying both BNIP3-mediated PINK1-PARK2-mediated mitophagy-induced attenuation The results showed cisplatin induced injury, ROS release, intracellular iron accumulation, lipid kidney, which were aggravated Bnip3 knockout, Pink1 knockout or Park2 cisplatin-treated mice. Ferrstatin-1, synthetic antioxidative inhibitor, rescued caused inhibition mitophagy. Thus, present study elucidated novel protects against renal tubular epithelial through ROS/HO1/GPX4 axis.
Language: Английский
Citations
108
Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)
Published: Oct. 16, 2023
Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.
Language: Английский
Citations
64
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 10, 2024
Abstract Immunotherapy has received widespread attention for its effective and long‐term tumor‐eliminating ability. However, immunogenic “cold” tumors, such as prostate cancer (PCa), the low immunogenicity of tumor itself is a serious obstacle to efficacy. Here, this work reports strategy enhance PCa by triggering cascade self‐enhanced ferroptosis in cells, turning from “hot”. This develops transformable self‐assembled peptide TEP‐FFG‐CRApY with alkaline phosphatase (ALP) responsiveness glutathione peroxidase 4 (GPX4) protein targeting. self‐assembles into nanoparticles under aqueous conditions transforms nanofibers response ALP during endosome/lysosome uptake promoting lysosomal membrane permeabilization (LMP). On one hand, released TEP‐FFG‐CRAY target GPX4 selectively degrade light irradiation, inducing ferroptosis; on other large amount leaked Fe 2+ further amplify through Fenton reaction. TEP‐FFG‐CRApY‐induced improves cell maturation dendritic cells (DCs) increasing intratumor T‐cell infiltration. More importantly, recovered T secreting amounts interferon‐gamma (IFN‐γ). provides novel molecular design synergistic molecularly targeted therapy tumors.
Language: Английский
Citations
26
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(2), P. 185 - 204
Published: Jan. 13, 2024
Abstract Cellular metabolism is the fundamental process by which cells maintain growth and self‐renewal. It produces energy, furnishes raw materials, intermediates for biomolecule synthesis, modulates enzyme activity to sustain normal cellular functions. foundation of life processes plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis recently discovered form iron‐dependent The inhibition ferroptosis crucial tumorigenesis tumor progression. However, metabolism, particularly glucose amino acid cancer not well understood. Here, we reviewed glucose, lipid, acid, iron selenium involvement elucidate impact different metabolic pathways on this process. Additionally, provided detailed overview agents used induce ferroptosis. We explained that maintaining intracellular redox homeostasis disrupting these renders them more susceptible iron‐induced death, resulting enhanced killing. combination inducers inhibitors may be novel approach future therapy an important strategy advance development treatments.
Language: Английский
Citations
23
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155907 - 155907
Published: March 12, 2025
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(12)
Published: Jan. 19, 2023
Ferroptosis is a non-apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc-/glutathione peroxidase 4 (GPX4) axis and iron are two main pathways regulating ferroptosis. Simultaneously, multiple also involved in ferroptosis regulation. an intense area current study. With improvement regulatory mechanisms that underlie ferroptosis, variety drugs associated with have been discovered developed for cancer therapy. Among them, traditional were initially. Small molecule compounds regulate signaling pathway complexes promote Fenton reaction become important inducing In recent years, emerging development nanotechnology has promoted research nanodrugs. Iron-based nanomaterials extensively tested as ferroptosis-inducing agents. Furthermore, nanoscale drug delivery systems offer suitable scaffold therapies. Traditional nanodrugs complementary, each their own strengths limitations. This review describes latest studies on regulation tumor cells focuses entanglement between To conclude, challenges perspectives this field put forward.
Language: Английский
Citations
38
Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16
Published: March 23, 2023
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while the non-receptor-mediated pathway, high concentrations reduce cystine uptake by inhibiting System Xc-, leading to intracellular glutathione depletion resulting ROS accumulation, which contributes increased lipid peroxidation, mitochondrial damage, ultimately Oxidative stress appears crosstalk between ferroptosis, it is essential maintain homeostasis inhibit oxidative responses vivo . As researchers work develop natural compounds further investigate complex mechanisms regulatory functions ferroptosis excitotoxicity, new avenues will be available for effective treatment ischaemic stroke. Therefore, this paper provides a review molecular glutamate-mediated
Language: Английский
Citations
30
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12928 - 12928
Published: Aug. 18, 2023
Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions patients, including those with overload other forms toxicity. Excess load an adverse prognostic factor diseases can cause serious organ damage fatalities following chronic red blood cell transfusions in patients many conditions, hemoglobinopathies, myelodyspasia, hematopoietic stem transplantation. Similar toxicity excess body but at a slower rate disease progression found idiopathic haemochromatosis patients. deposition different regions the brain suspected has been identified by MRI T2* similar methods neurodegenerative diseases, Alzheimer’s Parkinson’s disease. Based on its role as major biological catalyst free radical reactions Fenton reaction, also implicated associated pathology tissue damage. Furthermore, recent discovery ferroptosis, which death program based generation membrane lipid oxidation, sparked thousands investigations association cardiac, kidney, liver, cancer infections. The implications labile, non-protein bound form complexes dietary molecules such vitamin C drugs doxorubicin xenobiotic relation to carcinogenesis are discussed. In each case toxicity, mechanistic insights, diagnostic criteria, molecular interactions design new effective therapeutic interventions future targeted strategies. particular, this approach successful treatment most loading conditions especially transition thalassemia from fatal due protocols resulting complete elimination
Language: Английский
Citations
30