Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer DOI Creative Commons
Na Cui, Mingjie Li

annals of urologic oncology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 11, 2023

Prostate cancer (Pca) remains the most common malignancy worldwide in men, and second leading cause of mortality only to lung cancer. Besides surgery, androgen deprivation therapy (ADT) is a major treatment for Pca. However, ADT leads inevitable progression castration-resistant Pca (CRPC). The transition from hormone-dependent (ADPC) CRPC has been shown involve reactivation receptor (AR) signaling pathway. evidence become strong that develop adaptive mechanisms maintaining AR allow survival further evolution. This article mainly reviews research progress mechanism(s) provides scientific basis new ideas diagnosis this phenotype.

Language: Английский

Writers, readers, and erasers RNA modifications and drug resistance in cancer DOI Creative Commons
Di Chen, Xinyu Gu,

Yeltai Nurzat

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 30, 2024

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing this is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing. These modifications are pivotal regulating splicing, translation, transport, degradation, stability. Governed by "writers," "readers," "erasers," impact numerous biological processes progression, including cell proliferation, stemness, autophagy, invasion, apoptosis. Aberrant can lead drug adverse outcomes various cancers. Thus, targeting modification regulators offers a promising strategy for overcoming enhancing efficacy. This review consolidates recent research on role prevalent resistance, with focus m6A, m1A, m5C, m7G, Ψ, A-to-I Additionally, it examines regulatory mechanisms linked underscores existing limitations field.

Language: Английский

Citations

19
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation DOI
Milad Ashrafizadeh, Wei Zhang, Yu Tian

et al.

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 229 - 260

Published: Feb. 19, 2024

Language: Английский

Citations

17
RNA N6-methyladenosine modifications in urological cancers: from mechanism to application DOI
Lei Yang, Jianming Ying, Qian Tao

et al.

Nature Reviews Urology, Journal Year: 2024, Volume and Issue: 21(8), P. 460 - 476

Published: Feb. 12, 2024

Language: Английский

Citations

8
Chiral Supramolecular Nanofibers Regulated Tumor‐Derived Exosomes Secretion for Constructing an Anti‐Tumor Extracellular Microenvironment DOI
Beibei Wu, Xiaoqiu Dou, Yu Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: Feb. 29, 2024

Abstract Tumor‐derived exosomes (TDEs) induced extracellular microenvironment has recently been validated to be critical for tumor progression and metastasis, however, remodeling it oncotherapy still remains a major challenge due difficulty in regulation of TDEs secretion. Herein, the supramolecular chiral nanofibers, composed L/D ‐phenylalanine derivates (L/D‐Phe) linear hyaluronic acid (HA), are successfully employed construct anti‐tumor microenvironment. The left‐handed L‐Phe @HA nanofibers significantly inhibit secretion into microenvironment, which results suppression proliferation metastasis vitro vivo. Biological assays theoretical modeling reveal that these mainly attributed strong adsorption key transporters (Ras‐related protein Rab‐27A synaptosome‐associated 23) on via enhanced stereoselective interaction, leading degradation phosphorylated dropping transporters. Subsequently, transfer function is limited, causes remarkable inhibition These findings provide promising novel insight functional materials establish an

Language: Английский

Citations

4
The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system DOI Creative Commons
Ruiming Li,

Zhu Chunming,

Yuan Wang

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 17, 2024

Abstract N6-methyladenosine (m6A) methylation, a prevalent eukaryotic post-transcriptional modification, is involved in multiple biological functions, including mediating variable splicing, RNA maturation, transcription, and nuclear export, also vital for regulating translation, stability, cytoplasmic degradation. For example, m6A methylation can regulate pre-miRNA expression by affecting both splicing maturation. Non-coding (ncRNA), which includes microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular (circRNAs), does not encode proteins but has powerful impacts on transcription translation. Conversely, ncRNAs may impact the of regulators, miRNAs targeting mRNA or lncRNAs, circRNAs, acting as scaffolds to regulatory factors. Dysregulation common urinary tumors, role important these malignancies. This article provides systematic review mechanisms action tumors.

Language: Английский

Citations

4
HOXB13 in cancer development: molecular mechanisms and clinical implications DOI
Jian Zhang, Ying Li, Bo Peng

et al.

Frontiers of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0
YTHDC1 phase separation drives the nuclear export of m6A-modified lncNONMMUT062668.2 through the transport complex SRSF3–ALYREF–XPO5 to aggravate pulmonary fibrosis DOI Creative Commons
Sony Su Chen,

Yujie Wang,

Jinjin Zhang

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Fibroblast-to-myofibroblast differentiation is the main cytopathologic characteristic of pulmonary fibrosis. However, its underlying molecular mechanism remains poorly understood. This study elucidated that nuclear export lncNONMMUT062668.2 (lnc668) exacerbated fibrosis by activating fibroblast-to-myofibroblast differentiation. Mechanistic research revealed histone H3K9 lactylation in promoter region N6-methyladenosine (m6A) writer METTL3 was enriched to enhance transcription, leading lnc668 m6A modification. Meanwhile, reader YTHDC1 recognized m6A-modified and elevated METTL3-mediated Subsequently, phase-separating promoted lnc668. In this process, formed a pore complex with serine/arginine-rich splicing factor 3, Aly/REF factor, exportin-5 assist translocation from nucleus cytoplasm. After export, facilitated translation stability host gene phosphatidylinositol-binding clathrin assembly protein activate differentiation, aggravation fibrosis, which also depended on phase separation. first clarified separation crucial for modification, profibrotic role exacerbating These findings provide new insights into cytoplasmic lncRNAs identified potential targets therapy.

Language: Английский

Citations

0
Prognostic and therapeutic potential of copper-induced cell death-related lncRNAs in lung squamous cell carcinoma DOI Creative Commons
Zhe Tian, Lilan Cen,

Haoming Hua

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 3, 2025

Lung squamous cell carcinoma (LUSC), a major subtype of non-small lung cancer, remains challenging to treat due poor prognosis and limited therapeutic options. This study investigates the prognostic implications copper-induced death-related long non-coding RNAs (lncRNAs) in LUSC using data from The Cancer Genome Atlas. Five lncRNAs (AC010328.1, LINC01740, AL358613.2, MIR3945HG, AC002467.1) were identified as independent markers incorporated into risk score model stratify patients high- low-risk groups. Survival analyses revealed significant differences overall survival, with high-risk group exhibiting higher immune evasion potential poorer response immunotherapy. Functional enrichment highlighted involvement these drug metabolism tumor biology. Furthermore, mutation burden analysis dysfunction evaluation confirmed clinical relevance model, identifying more sensitive targeted drugs such Quizartinib Dasatinib. A Nomogram integrating lncRNA scores factors demonstrated robust predictive accuracy for 1-, 3-, 5-year survival outcomes. provides novel biomarkers actionable insights improving assessment personalizing immunotherapy strategies patients.

Language: Английский

Citations

0
YTHDC1 orchestrates oncogenic splicing via the CLK1-SRSF1 splicing machinery to regulate castration-resistant prostate cancer progression DOI
Parth Gupta, Devesh Srivastava, Vinayak Nayak

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Language: Английский

Citations

0
Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5 DOI Creative Commons
Ceyhan Hacıoğlu, Didem Oral

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Hepatocellular carcinoma (HCC) presents a persistent challenge to conventional therapeutic approaches. SLC12A5 is implicated in an oncogenic capacity and facilitates the progression of cancer. The objective this investigation scrutinize inhibitory effects borax on endoplasmic reticulum (ER)-stress apoptosis mediated by HepG2 cells. Initially, we evaluated cytotoxic impact both HL-7702 cell lines. Subsequently, cellular morphology cycle these lines were examined. Following this, explored treatment mRNA protein expression levels SLC12A5, C/EBP homologous (CHOP), glucose-regulated protein-78 (GRP78), activating transcription factor-6 (ATF6), caspase-3 (CASP3), cytochrome c (CYC) populations. determined IC50 value for cells was 40.8 mM, whereas cells, 22.6 mM. concentrations (22.6 mM) IC75 (45.7 did not manifest morphological aberrations Conversely, induced observable nuclear abnormalities, resulting arrest G1/G0 phase. Additionally, ATF6, CHOP, GRP78, CASP3, CYC elevated comparison Moreover, decreased following exhibited significant increase. In conclusion, our data highlight potential through regulation ER stress HCC targeting SLC12A5.

Language: Английский

Citations

3