Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2507 - 2528
Published: March 1, 2024
Background:
Cancer
continues
to
be
a
prominent
issue
in
the
field
of
medicine,
as
demonstrated
by
recent
studies
emphasizing
significant
role
autophagy
development
cancer.
Traditional
Chinese
Medicine
(TCM)
provides
variety
anti-tumor
agents
capable
regulating
autophagy.
However,
clinical
application
autophagy-modulating
compounds
derived
from
TCM
is
impeded
their
restricted
water
solubility
and
bioavailability.
To
overcome
this
challenge,
utilization
nanotechnology
has
been
suggested
potential
solution.
Nonetheless,
current
body
literature
on
nanoparticles
delivering
TCM-derived
for
cancer
treatment
limited,
lacking
comprehensive
summaries
detailed
descriptions.
Methods:
Up
November
2023,
research
study
was
conducted
gather
relevant
data
using
databases,
including
PubMed,
ScienceDirect,
Springer
Link,
Web
Science,
CNKI.
The
keywords
utilized
investigation
included
"autophagy",
"nanoparticles",
"traditional
medicine"
"anticancer".
Results:
This
review
analysis
overcoming
delivery
challenges
enhancing
anti-cancer
properties
TCM.
evaluation
based
synthesis
different
classes
TCM,
mechanisms
action
treatment,
benefits
reported
various
scholarly
sources.
findings
indicate
that
shows
availability
thereby
opening
up
plethora
therapeutic
avenues.
Conclusion:
Nanotechnology
enhance
efficacy
traditional
through
regulation
Keywords:
autophagy,
nano-delivery,
anti-cancer,
medicine
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 23, 2024
There
are
increasing
concerns
regarding
the
rapid
expansion
of
polystyrene
nanoplastics
(PS-NPs),
which
could
impact
human
health.
Previous
studies
have
shown
that
can
be
transferred
from
mothers
to
offspring
through
placenta
and
breast
milk,
resulting
in
cognitive
deficits
offspring.
However,
neurotoxic
effects
maternal
exposure
on
its
mechanisms
remain
unclear.
In
this
study,
PS-NPs
(50
nm)
were
gavaged
female
rats
throughout
gestation
lactation
establish
an
model
study
neurotoxicity
behavioral
changes
caused
by
Neonatal
rat
hippocampal
neuronal
cells
used
investigate
pathways
NPs
induce
neurodevelopmental
toxicity
rats,
using
iron
inhibitors,
autophagy
reactive
oxygen
species
(ROS)
scroungers,
P53
NCOA4
inhibitors.
We
found
low
dosages
cause
ferroptosis
hippocampus
offspring,
a
decline
cognitive,
learning,
memory
abilities
induced
NOCA4-mediated
ferritinophagy
promoted
inciting
ROS
production
activate
P53-mediated
ferritinophagy.
Furthermore,
levels
antioxidant
factors
glutathione
peroxidase
4
(GPX4)
(GSH),
responsible
for
ferroptosis,
reduced.
summary,
revealed
consumption
during
damage
Our
results
serve
as
basis
further
research
into
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
