Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136894 - 136894
Published: Dec. 15, 2024
Language: Английский
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2023, Volume and Issue: 32(2), P. 241 - 249
Published: Dec. 7, 2023
Breast cancer has surpassed lung to become the most common malignancy worldwide. The incidence rate and mortality of breast continue rise, which leads a great burden on public health. Circular RNAs (circRNAs), new class noncoding (ncRNAs), have been recognized as important oncogenes or suppressors in regulating initiation progression. In cancer, circRNAs significant roles tumorigenesis, recurrence multidrug resistance that are mediated by various mechanisms. Therefore, may serve promising targets therapeutic strategies for management. This study reviews recent studies about biosynthesis characteristics diagnosis, treatment prognosis evaluation, well value clinical applications biomarkers cancer. Understanding mechanisms function could help transform basic research into facilitate development novel circRNA-based treatment.
Language: Английский
Citations
57
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 17, 2025
Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding in eukaryotes. Studies demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles tumorigenesis, metastasis, drug response cancer by influencing expression altering the processes tumor initiation progression. This review aims summarize recent advances research on circRNA-protein interactions (CPIs) discuss functions mode action CPIs at various stages expression, including transcription, splicing, translation, post-translational modifications context cancer. Additionally, we explore role resistance gain deeper understanding potential applications development new anti-cancer therapeutic approaches.
Language: Английский
Citations
1
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155651 - 155651
Published: Oct. 19, 2024
Language: Английский
Citations
6
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 25, 2025
Over the past decade, circular RNAs (circRNAs) have gained recognition as a novel class of genetic molecules, many which are implicated in cancer pathogenesis via different mechanisms, including drug resistance, immune escape, and radio-resistance. ExosomalcircRNAs, particular, facilitatecommunication between tumour cells micro-environmental cells, fibroblasts, other components. Notably, can reportedly influence progression treatment resistance by releasing exosomalcircRNAs. circRNAs often exhibit tissue- cancer-specific expression patterns, growing evidence highlights their potential clinical relevance utility. These molecules show strong promise biomarkers therapeutic targets for diagnosis treatment. Therefore, this review aimed to briefly discuss latest findings on roles mechanisms key various malignancies, lung, breast, liver, colorectal, gastric cancers, well haematological malignancies neuroblastoma.This will contribute identification new circRNA early cancer.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 10, 2025
Breast cancer is the leading cause of cancer-related death in women worldwide, and its developmental mechanisms involve complex factors. Recent studies have shown that ferroptosis closely related to occurrence progression breast cancer. However, role circular RNAs (circRNAs) regulating remains unclear. In this study, we investigated regulatory circSCD1 (hsa_circ_0019512) We examined expression cell lines explored impact on viability colony formation. also evaluated involvement by measuring levels malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), intracellular iron. vivo xenograft experiments were performed confirm promoting tumor growth inhibiting ferroptosis.Furthermore, mechanism which regulates SCD1 protein stability through ubiquitination identified interaction between deubiquitinase OTUB1. Our results showed was upregulated promoted Knockdown increased MDA ROS levels, decreased GSH enhanced cells. vivo, knockdown significantly reduced size weight, while overexpression growth. Mechanistically, interacted with OTUB1 inhibit degradation protein, thereby stabilizing expression. Rescue demonstrated partially reversed effects proliferation ferroptosis. findings suggest plays a crucial stability. Targeting circSCD1/OTUB1/SCD1 axis may provide potential therapeutic strategy for treatment.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 158 - 158
Published: Jan. 29, 2024
Breast cancer (BC), characterized by high heterogeneity, is the most commonly reported malignancy among females across globe. Every year, many BC patients die owing to delayed diagnosis and treatment. Increasing researches have indicated that aberrantly expressed circular RNAs (circRNAs) are implicated in tumorigenesis progression of various tumors, including BC. Hence, this article provides a summary biogenesis functions circRNAs, as well an examination how circRNAs regulate Moreover, aroused incremental attention potential diagnostic prognostic biomarkers for Exosomes enriched with can be secreted into tumor microenvironment mediate intercellular communication, affecting Detecting expression levels exosomal may provide reference prognosis prediction. Illuminating insights earlier better treatment regimens will potentially available following elucidation deeper regulatory mechanisms malignancy.
Language: Английский
Citations
2
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: Nov. 16, 2024
RNA splicing is a fundamental step of gene expression. While constitutive removes introns and joins exons unbiasedly, alternative (AS) selectively determines the assembly to generate variants corresponding same transcript. The biogenesis circular RNAs (circRNAs) inextricably associated with AS. Back-splicing, biogenic process circRNA, special form In cancer, both AS circRNA deviate from original track. present review, we delve into intricate interplay between circRNAs in context cancer. relationship intricate, where modulates return regulate events. Beyond that, epigenetic posttranscriptional modifications concurrently circRNAs. On basis this modality, summarize current knowledge on how factors other binding proteins biogenesis, interact influence Specifically, feedback loop regulation events contributes greatly oncogenesis cancer progression. summary, resolving crosstalk will not only provide better insight biology but also provoke novel strategies combat
Language: Английский
Citations
2
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155569 - 155569
Published: Aug. 29, 2024
Language: Английский
Citations
1
Annals of Medicine, Journal Year: 2024, Volume and Issue: 57(1)
Published: Dec. 23, 2024
Background Quaking (QKI) is a member of the signal transduction and activators RNA (STAR) family, performing crucial multifunctional regulatory role in alternative splicing, mRNA precursor processing, transport localization, stabilization, translation during tumour progression. Abnormal QKI expression or fusion mutations lead to aberrant protein expression, thereby promoting However, many types tumour, played as suppressor, progression remains ambiguous.
Language: Английский
Citations
1
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 23, 2024
Abstract Emergence of chemotherapeutic resistance remains an important challenge in cancer treatment, especially advanced cancers. Recent studies have shown that ferroptosis is closely associated with tumor chemoresistance, and induction has been to reverse chemoresistance. This study focused on the function Ring Finger Protein 181 (RNF181) gastric potential mechanisms involved Here, we found RNF181 was aberrantly activated chemoresistant cells cancer, high expression poor patient prognosis. Depletion inhibited proliferation tumorigenicity cells, increased drug sensitivity. Mechanistically, our showed interaction between HMOX1 mediated K27-linked polyubiquitination regulated its protein stability. Upregulation after knockdown resulted excessive heme degradation intracellular iron overload promote ferroptosis. Generally, reveals role chemoresistance targeting may be a rational strategy improve efficacy chemotherapy cancer.
Language: Английский
Citations
0