Ferroptosis-Related Gene Signatures: Prognostic Role in HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 530 - 530

Published: Feb. 5, 2025

Background: Despite advances in the management of head and neck squamous cell carcinoma (HNSCC), prognostic models treatment strategies remain inadequate, particularly for HPV-positive oropharyngeal (OPSCC). The rising incidence OPSCC highlights an urgent need innovative therapeutic approaches. Ferroptosis, a regulated form non-apoptotic death, has gained attention its role cancer progression, but potential as target remains largely unexplored. This study investigates ferroptosis OPSCC, aiming to identify markers provide insights into that could improve patient outcomes. Methods: Thirteen gene expression signatures were retrieved from literature, their performance association immune microenvironment validated on meta-analysis 267 cases (Metanalysis-HPV267) 286 samples BD2Decide project (BD2-HPV286). Results: Our analysis revealed specific ferroptosis-related signatures, FER3, FER4, FER6, FER12, are significantly associated (p-value < 0.05) with high-risk groups adverse tumor features, including suppressed activity enhanced stromal involvement. Elevated CAV1, suppressor, further delineates profiles. Conclusions: These findings highlight significance stratifying patients identifying those poorer clinical Targeting pathways represents novel promising approach addressing unmet effective OPSCC. Future research should focus translating these applications advance precision oncology outcomes this growing population.

Language: Английский

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Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Oct. 17, 2024

It has long been widely acknowledged that ultraviolet (UV) light is an environment risk factor can lead to cancer, particularly skin cancer. However, it worth noting UV radiation holds potential for cancer treatment as a relatively high-energy electromagnetic wave. With the help of nanomaterials, role caught increasing attention in treatment. In this review, we briefly summarized types UV-induced cancers, including malignant melanoma, squamous cell carcinoma, basal Merkel carcinoma. Importantly, discussed primary mechanisms underlying carcinogenesis, mutations by DNA damage, immunosuppression, inflammation and epigenetic alterations. Historically limited its shallow penetration depth, introduction nanomaterials dramatically transformed utilization The direct effect itself generally leads suppression growth initiation apoptosis ferroptosis. also be utilized activate photosensitizers reactive oxygen species (ROS) production, sensitize radiotherapy achieve controlled drug release. Finally, comprehensively weigh significant risks limitations associated with therapeutic use radiation. And contradictory exposure promoting inhibiting tumor discussed. This review provides clues clinical therapy well future study directions field. precise delivery control or wavelength dose effects are needed thorough understanding

Language: Английский

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Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4559 - 4559

Published: April 22, 2024

Oxidative stress and lipid peroxidation play important roles in numerous physiological pathological processes, while the bioactive products of peroxidation, hydroperoxides reactive aldehydes, act as mediators redox signaling normal malignant cells. Many types cancer, including osteosarcoma, express altered pathways. Such pathways protect cancer cells from cytotoxic effects oxidative stress, thus supporting transformation, eventually anticancer therapies associated with stress. In this review, we aim to explore status osteosarcoma highlight involvement pathways, therapies.

Language: Английский

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Realgar Transforming Solution Triggered Ferroptosis in Leukemia Cells by Disrupting Iron Homeostasis Through the Slc7a11/Gpx4 Axis

Published: Jan. 1, 2025

Clinical investigations have demonstrated that the progression of acute myeloid leukemia (AML) is particularly susceptible to iron overload and dysregulation homeostasis, which can trigger ferroptosis. Consequently, regulating homeostasis may positively impact AML treatment. This study aimed investigate anticancer properties potential mechanisms realgar transforming solution (RTS) in inducing ferroptosis disrupting NB4 cells. Cell viability was assessed using Counting Kit-8 (CCK-8) assay. Transcriptomic analysis conducted identify differentially expressed genes (DEGs) predict pathways through RTS exerts its antitumor effects. Ferroptosis evaluated BODIPY C11 lipid ROS probe, T-SOD, MDA, GSH assay kits, along with JC-1 fluorescent probe Western blot analysis. Iron Fe2+ kits metabolism. Transcriptome sequencing revealed 819 DEGs, HO-1 PML-RARα Regulated Adaptor Molecule 1 (PRAM1) being most prominent. KEGG indicated significant enrichment pathway. In vitro studies treatment resulted increased levels depletion SLC7A11 GPX4 expression Additionally, TFR1 NCOA4 increased, while FPN1 (SLC40A1), FTH1, IREB2 decreased under led intracellular accumulation, ultimately Pretreatment inhibitors, such as Ferrostatin-1 (Fer-1) or Deferoxamine mesylate (DFOM), attenuated RTS-induced The demonstrates induce cells by via regulation SLC7A11/GPX4 axis. These findings suggest a therapeutic agent for AML.

Language: Английский

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Tribbles Pseudokinase 3 Converts Sorafenib Therapy to Neutrophil‐Mediated Lung Metastasis in Hepatocellular Carcinoma

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Rapid development of resistance to sorafenib and subsequent hyperprogression in patients with advanced hepatocellular carcinoma (HCC) pose significant challenges, the underlying mechanisms still largely unknown. Herein, sorafenib-induced TRIB3 is identified as a liver-specific determinant driving secondary by facilitating accumulation protumorigenic neutrophils within tumors. Mechanistically, TRIB3, triggered sorafenib-elicited ROS-ER stress axis, operates an NF-κB-dependent manner upregulate CXCR1/2 ligands, subsequently promoting neutrophil recruitment into These enriched enhance epithelial-mesenchymal transition processes malignant cells through oncostatin M-STAT3 pathway, thereby repurposing therapeutic efficacy away from anti-angiogenesis toward lung metastasis. Clinically, elevated expression indicates inferior survival unfavorable clinical HCC patients. Correspondingly, strategies that either inhibiting upregulation or blocking its downstream signaling successfully augment prevent vivo. The study thus identifies pivotal mechanism HCC, centered on TRIB3-mediated disease hyperprogression.

Language: Английский

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Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104674 - 104674

Published: Feb. 1, 2025

Language: Английский

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Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

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Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111733 - 111733

Published: March 1, 2025

Language: Английский

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Research progress on ferroptosis in head and neck squamous cell carcinoma

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 17, 2025

Language: Английский

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Identification of a novel signature derived from ferroptosis-related genes to predict prognosis, immune landscape and chemotherapeutic sensitivity in head and neck squamous cell carcinoma

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102392 - 102392

Published: April 1, 2025

Language: Английский

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