Deciphering the roles of the HMGB family in cancer: Insights from subcellular localization dynamics DOI Creative Commons

Junqing Jiang,

Mengyu Sun, Yufei Wang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 78, P. 85 - 104

Published: July 14, 2024

The high-mobility group box (HMGB) family consists of four DNA-binding proteins that regulate chromatin structure and function. In addition to their intracellular functions, recent studies have revealed involvement as extracellular damage-associated molecular patterns (DAMPs), contributing immune responses tumor development. HMGB promotes tumorigenesis by modulating multiple processes including proliferation, metabolic reprogramming, metastasis, evasion, drug resistance. Due the predominant focus on HMGB1 in literature, little is known about remaining members this family. This review summarizes structural, distributional, well functional similarities distinctions among family, followed a comprehensive exploration roles We emphasize distributional hierarchy at both organizational subcellular levels, with relationship microenvironment (TIME), aiming prospect potential strategies for anticancer therapy.

Language: Английский

Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery DOI Creative Commons
Junyu Wu, Guping Tang, Chien‐shan Cheng

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

Citations

7
Mitochondrial alterations and signatures in hepatocellular carcinoma DOI Creative Commons
Tsung‐Hsien Chen, Shu-Hsien Lin, Ming‐Yang Lee

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Emerging roles for Mitochondrial Rho GTPases in tumor biology DOI Creative Commons
Dillon P. Boulton, M. Cecilia Caino

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(9), P. 107670 - 107670

Published: Aug. 14, 2024

Language: Английский

Citations

3
Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions DOI Creative Commons
Veronica Marabitti, Elisabetta Vulpis, Francesca Nazio

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107382 - 107382

Published: Aug. 30, 2024

It is now recognized that tumors are not merely masses of transformed cells but intricately interconnected with healthy in the tumor microenvironment (TME), forming complex and heterogeneous structures. Recent studies discovered cancer can steal mitochondria from to empower themselves, while reducing functions their target organ. Mitochondrial transfer, i.e. intercellular movement mitochondria, recently emerging as a novel process biology, contributing growth, metastasis, resistance therapy by shaping metabolic landscape microenvironment. This review highlights influence transferred on bioenergetics, redox balance apoptotic resistance, which collectively foster aggressive phenotype. Furthermore, therapeutic implications mitochondrial transfer discussed, emphasizing potential targeting these pathways overcome drug improve treatment efficacy.

Language: Английский

Citations

2
Multifaceted role of HMGB1: From nuclear functions to cytoplasmic and extracellular signaling in inflammation and cancer—Review DOI

Desislava Vladimirova,

Sonya Staneva,

Iva Ugrinova

et al.

Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown, P. 271 - 300

Published: Oct. 30, 2024

Language: Английский

Citations

2
Deciphering the roles of the HMGB family in cancer: Insights from subcellular localization dynamics DOI Creative Commons

Junqing Jiang,

Mengyu Sun, Yufei Wang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 78, P. 85 - 104

Published: July 14, 2024

The high-mobility group box (HMGB) family consists of four DNA-binding proteins that regulate chromatin structure and function. In addition to their intracellular functions, recent studies have revealed involvement as extracellular damage-associated molecular patterns (DAMPs), contributing immune responses tumor development. HMGB promotes tumorigenesis by modulating multiple processes including proliferation, metabolic reprogramming, metastasis, evasion, drug resistance. Due the predominant focus on HMGB1 in literature, little is known about remaining members this family. This review summarizes structural, distributional, well functional similarities distinctions among family, followed a comprehensive exploration roles We emphasize distributional hierarchy at both organizational subcellular levels, with relationship microenvironment (TIME), aiming prospect potential strategies for anticancer therapy.

Language: Английский

Citations

1