World Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
15(6), P. 929 - 941
Published: Dec. 1, 2024
The
effectiveness
of
immune
checkpoint
therapy
highlights
the
need
to
understand
abnormal
programmed
cell
death
protein-1
(PD-1)
expression
in
nasopharyngeal
carcinoma
(NPC),
especially
when
treatments
fail,
or
resistance
develops.
Interferon
gamma
(IFN-γ)
signaling
is
crucial
for
regulating
death-ligand
1
(PD-L1)
expression.
Our
study
focuses
on
interferon
receptor
2
(IFNGR2),
an
essential
part
IFN-γ
pathway,
and
its
impact
malignant
traits
NPC.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 27, 2024
Abstract
The
development
of
drug
resistance
remains
a
major
challenge
in
cancer
treatment.
Ferroptosis,
unique
type
regulated
cell
death,
plays
pivotal
role
inhibiting
tumour
growth,
presenting
new
opportunities
treating
chemotherapeutic
resistance.
Accumulating
studies
indicate
that
epigenetic
modifications
by
non-coding
RNAs
(ncRNA)
can
determine
vulnerability
to
ferroptosis.
In
this
review,
we
first
summarize
the
growth/development.
Then,
core
molecular
mechanisms
ferroptosis,
its
upstream
regulation,
and
downstream
effects
on
Finally,
review
recent
advances
understanding
how
ncRNAs
regulate
ferroptosis
from
such
modulate
This
aims
enhance
general
ncRNA-mediated
regulatory
which
highlighting
ncRNA-ferroptosis
axis
as
key
druggable
target
overcoming
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 21, 2024
Circular
RNAs
(circRNAs)
are
unique
noncoding
that
have
a
closed
and
stable
loop
structure
generated
through
backsplicing.
Due
to
their
conservation,
stability
tissue
specificity,
circRNAs
can
potentially
be
used
as
diagnostic
indicators
therapeutic
targets
for
certain
tumors.
Many
studies
shown
act
microRNA
(miRNA)
sponges,
engage
in
interactions
with
proteins
translation
templates
regulate
gene
expression
signal
transduction,
thereby
participating
the
occurrence
development
of
variety
malignant
Immunotherapy
has
revolutionized
treatment
cancer.
Early
researches
indicated
involved
regulating
tumor
immune
microenvironment
antitumor
immunity.
CircRNAs
may
potential
important
increasing
sensitivity
immunotherapy
expanding
population
patients
who
benefit
from
cancer
immunotherapy.
However,
few
investigated
correlation
between
In
this
review,
we
summarize
current
on
regulation
different
mechanisms
value
efficacy
goal
providing
new
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 11, 2025
Introduction
Prostate
cancer
(PC)
is
a
leading
cause
of
cancer-related
deaths
among
men,
often
progressing
to
castration-resistant
prostate
(CRPC)
after
androgen
deprivation
therapy
(ADT).
A
subset
CRPC
evolves
into
treatment-emergent
neuroendocrine
(t-NEPC),
an
aggressive
form
characterized
by
poor
prognosis.
Currently,
there
no
reliable
biomarker
for
early
detection
t-NEPC.
Circular
RNAs
(circRNAs)
have
emerged
as
potential
biomarkers
due
their
stability
and
tissue-specific
expression.
Methods
In
this
study,
we
investigated
the
circRNA
landscape
during
transdifferentiation
(NED)
PC
cells
using
androgen-sensitive
LNCaP
androgen-insensitive
DU145
cell
lines.
To
achieve
that,
applied
CirComPara2
pipeline
publicly
available
datasets
identify
differently
expressed
circRNAs
in
lines
pre-
post-transdifferentiation.
After
validation
functional
analysis
RNA-interference
was
selected
explore
its
role
NED.
Results
We
identified
over
6,200
circRNAs,
which
33
were
differentially
Among
them,
novel
circRNA,
circPCDH11Y,
highly
upregulated
transition
from
epithelial
phenotype,
while
levels
remained
unchanged
cells.
Functional
assays
demonstrated
that
circPCDH11Y
plays
regulating
expression
key
markers,
including
synaptophysin
(SYP),
neuron-specific
enolase
(ENO2),
prostate-specific
antigen
(PSA),
Brain-Specific
Homeobox/POU
Domain
Protein
2
(BRN2)
linear
Protocadherin
11
Y-Linked
(PCDH11Y).
Silencing
delayed
SYP,
ENO2
PCDH11Y,
increasing
PSA
BRN2
transcriptional
levels,
indicating
involvement
promoting
differentiation.
Additionally,
detected
extracellular
vesicles
(EVs)
secreted
post-NED,
suggesting
circulating
biomarker.
Discussion
These
findings
highlight
promising
candidate
t-NEPC
provide
new
insights
molecular
mechanisms
underlying
progression.
Further
clinical
samples
required
establish
diagnostic
therapeutic
potential,
could
significantly
improve
management
treatment-resistant
cancer.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 853 - 853
Published: April 2, 2025
DLBCL
is
a
testament
to
the
complexity
of
nature.
It
characterized
by
remarkable
diversity
in
its
molecular
and
pathological
subtypes
clinical
manifestations.
Despite
strides
made
treatment
introduction
innovative
drugs,
around
one-third
patients
face
relapse
or
develop
refractory
disease.
Recent
findings
over
past
ten
years
have
highlighted
critical
interplay
between
evolution
various
epigenetic
mechanisms,
including
chromatin
remodeling,
DNA
methylation,
histone
modifications,
regulatory
roles
non-coding
RNAs.
These
alterations
are
integral
pathways
oncogenesis,
tumor
progression,
development
therapeutic
resistance.
In
decade,
identification
dysregulated
mechanisms
lymphomas
has
paved
way
for
an
exciting
field
therapies.
Crucially,
these
transformations
span
beyond
cells
include
sophisticated
network
within
microenvironment
(TME).
While
exploration
dysregulation
lymphoma
thriving,
affecting
functions
immune
TME
invite
further
investigation.
This
review
dedicated
weaving
together
narrative
impacting
both
with
focus
on
their
infiltrating
companions.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 24, 2025
Lung
cancer
remains
a
leading
cause
of
cancer-related
mortality
worldwide.
Its
progression
is
intricately
associated
with
the
dynamic
regulation
autophagy
and
RNA-binding
proteins
(RBPs),
which
play
crucial
roles
in
mRNA
stability,
alternative
splicing,
cellular
stress
responses.
This
review
aims
to
systematically
analyze
mechanisms
through
RBPs
contribute
lung
explore
potential
therapeutic
strategies
targeting
these
pathways.
We
reviewed
recent
studies
on
molecular
by
regulate
tumor
proliferation,
metabolic
adaptation,
their
interaction
autophagy.
The
also
examines
dual
cancer,
highlighting
its
context-dependent
effects
cell
survival
death.
interactions
regulatory
networks
between
involve
multiple
levels
regulation.
can
directly
influence
processes
act
as
microRNA
(miRNA)
sponges
stability.
modulation
affects
expression
autophagy-related
genes
(ATGs)
autophagosome
formation.
Additionally,
participate
complex
non-coding
RNAs
(ncRNAs),
including
long
(lncRNAs),
circular
(circRNAs),
other
proteins.
proposes
innovative
that
combine
RBP-targeting
approaches
(e.g.,
small
molecule
inhibitors,
CRISPR
gene
editing)
modulators
mTOR
chloroquine)
enhance
treatment
efficacy.
Nanoparticle
drug
delivery
systems
epigenetic
offer
further
opportunities
for
targeted
interventions.
lays
theoretical
foundation
advancing
research
provides
novel
insights
into
synergistic
therapies
target
both
improve
outcomes
cancer.
