Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor DOI

Ruobing Liu,

Juanjuan Wang, Yuqing Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217115 - 217115

Published: July 17, 2024

Language: Английский

Ferroptosis is an effective strategy for cancer therapy DOI
Afrasyab Khan,

Yu Huo,

Yilei Guo

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(5)

Published: April 23, 2024

Language: Английский

Citations

7
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects DOI
Y. F. Lu,

Xiao‐Ting Xie,

Lianxiang Luo

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(11-12), P. 1914 - 1943

Published: July 15, 2024

Language: Английский

Citations

7
LACTB suppresses liver cancer progression through regulation of ferroptosis DOI Creative Commons

Kaixuan Zeng,

Na Huang, Nanbin Liu

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103270 - 103270

Published: July 18, 2024

Ferroptosis, driven by iron-dependent phospholipid peroxidation, is emerging as an intrinsic cancer defense mechanism. However, the regulatory networks involved in ferroptosis remain largely unknown. Here, we found that serine beta-lactamase-like protein (LACTB) inhibits liver progression regulating ferroptosis. LACTB downregulated cancer, and ectopic expression of markedly cell viability, colony formation, tumour growth. knockout exerts opposite effects. Further investigation revealed blocks HSPA8 transcription a p53-dependent manner, resulting elevation NCOA4-mediated ferritinophagy inhibition SLC7A11/GSH/GPX4 signalling, thereby triggering suppressing progression. Liver cells with endogenous mutation p53 binding site promoter exhibited increased resistance to inducers, ferroptosis-promoting effect was significantly weakened these mutant cells. Importantly, identified downstream target lenvatinib, adeno-associated virus-mediated overexpression knockdown notably enhance attenuate anti-tumour efficacy lenvatinib vivo, respectively. Taken together, our study reveals novel action provides potential therapeutic strategies for enhancing cancer.

Language: Английский

Citations

7
Targeting Ferroptosis as an Advance Strategy in Cancer Therapy DOI
Tobias Achu Muluh, Qianqian Fu,

Xiaojiao Ai

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 41(10-12), P. 616 - 636

Published: July 3, 2024

This study innovates by systematically integrating the molecular mechanisms of iron death and its application in cancer therapy. By deeply analyzing interaction between tumor microenvironment, provides a new theoretical basis for treatment directions developing more effective strategies. In addition, points to critical issues barriers that need be addressed future research, providing valuable insights into use clinical translation.

Language: Английский

Citations

6
Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor DOI

Ruobing Liu,

Juanjuan Wang, Yuqing Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217115 - 217115

Published: July 17, 2024

Language: Английский

Citations

5