Aging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
Inflammation
plays
a
pivotal
role
in
the
age-related
decline
of
skeletal
muscle
mass,
leading
to
sarcopenia
elderly.
The
prevalence
notably
increases
among
males
aged
≥
70.
However,
it
remains
unclear
whether
inflammatory
indexes
are
associated
with
reduction
mass
elderly
population.
Thirty-one
70,
without
severe
diseases
or
dementia,
were
enrolled
study.
They
underwent
measurements,
physical
and
hematological
tests
at
onset
study
after
one-year
follow-up.
Twenty-eight
participants
successfully
followed
for
one
year.
Appendicular
index
(ASMI)
decreased
by
3.30
±
2.41%
14
increased
2.66
1.61%
other
compared
baseline
levels.
neutrophil-to-lymphocyte
ratio
(NLR)
was
2.14
0.56
ASMI-decreased
group
1.66
0.62
ASMI-increased
group.
A
statistically
significant
negative
correlation
found
between
NLR
change
ASMI
linear
regression
analyses.
area
under
curve
(AUC)
predicting
0.724,
an
optimal
sensitivity
64.3%
specificity
78.6%
cut-off
value
1.94.
emerged
as
potential
prognostic
marker
males.
further
studies
necessary
assess
its
clinical
utility.
Molecular Aspects of Medicine,
Journal Year:
2024,
Volume and Issue:
97, P. 101270 - 101270
Published: April 6, 2024
The
onset
of
sarcopenia
is
intimately
linked
with
aging,
posing
significant
implications
not
only
for
individual
patient
quality
life
but
also
the
broader
societal
healthcare
framework.
Early
and
accurate
identification
a
comprehensive
understanding
its
mechanistic
underpinnings
therapeutic
targets
paramount
to
addressing
this
condition
effectively.
This
review
endeavors
present
cohesive
overview
recent
advancements
in
research
diagnosis.
We
initially
delve
into
contemporary
diagnostic
criteria,
specifically
referencing
European
Working
Group
on
Sarcopenia
Older
People
(EWGSOP)
2
Asian
(AWGS)
2019
benchmarks.
Additionally,
we
elucidate
assessment
techniques
muscle
strength,
quantity,
physical
performance,
highlighting
tools
such
as
grip
chair
stand
test,
dual-energy
X-ray
Absorptiometry
(DEXA),
bioelectrical
impedance
analysis
(BIA),
gait
speed,
short
performance
battery
(SPPB),
while
discussing
their
inherent
advantages
limitations.
Such
pave
way
early
unequivocal
diagnosis
sarcopenia.
Proceeding
further,
provide
deep-dive
sarcopenia's
pathogenesis,
offering
thorough
examination
associated
signaling
pathways
like
Myostatin,
AMP-activated
protein
kinase
(AMPK),
insulin/IGF-1
Signaling
(IIS),
nuclear
factor
kappa-light-chain-enhancer
activated
B
cells
(NF-κB)
pathways.
Each
pathway's
role
mediation
detailed,
underscoring
potential
target
avenues.
From
perspective,
underscores
pivotal
mitochondrial
dysfunction
sarcopenia,
emphasizing
elements
oxidative
overload,
biogenesis,
mitophagy,
significance.
At
last,
capture
strides
made
treatment,
ranging
from
nutritional
exercise
interventions
pharmacological
supplementation
strategies.
In
sum,
meticulously
synthesizes
latest
scientific
developments
aiming
enhance
precision
clinical
practice
insights
refined
innovative
interventions,
ultimately
contributing
optimized
care
field.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 12, 2023
Programmed
cell
death
has
crucial
roles
in
the
physiological
maturation
of
an
organism,
maintenance
metabolism,
and
disease
progression.
Pyroptosis,
a
form
programmed
which
recently
received
much
attention,
is
closely
related
to
inflammation
occurs
via
canonical,
non-canonical,
caspase-3-dependent,
unclassified
pathways.
The
pore-forming
gasdermin
proteins
mediate
pyroptosis
by
promoting
lysis,
contributing
outflow
large
amounts
inflammatory
cytokines
cellular
contents.
Although
response
critical
for
body’s
defense
against
pathogens,
uncontrolled
can
cause
tissue
damage
vital
factor
occurrence
progression
various
diseases.
In
this
review,
we
briefly
summarize
major
signaling
pathways
discuss
current
research
on
pathological
function
autoinflammatory
diseases
sterile
Progress in Retinal and Eye Research,
Journal Year:
2024,
Volume and Issue:
101, P. 101263 - 101263
Published: April 23, 2024
Retinal
diseases
encompass
various
conditions
associated
with
sight-threatening
immune
responses
and
are
leading
causes
of
blindness
worldwide.
These
include
age-related
macular
degeneration,
diabetic
retinopathy,
glaucoma
uveitis.
Emerging
evidence
underscores
the
vital
role
innate
response
in
retinal
diseases,
beyond
previously
emphasized
T-cell-driven
processes
adaptive
system.
In
particular,
pyroptosis,
a
newly
discovered
programmed
cell
death
process
involving
inflammasome
formation,
has
been
implicated
loss
membrane
integrity
release
inflammatory
cytokines.
Several
disease-relevant
animal
models
have
provided
that
formation
inflammasomes
induction
pyroptosis
cells
contribute
to
inflammation
diseases.
this
review
article,
we
summarize
current
knowledge
about
system
We
also
provide
insights
into
translational
targeting
approaches,
including
novel
drugs
countering
improve
diagnosis
treatment
British Journal of Dermatology,
Journal Year:
2024,
Volume and Issue:
191(3), P. 385 - 396
Published: April 23, 2024
Psoriasis
is
a
common
chronic
inflammatory
disease
with
an
unclear
aetiology.
Keratinocytes
in
psoriasis
are
susceptible
to
exogenous
triggers
that
induce
cell
death.
European Journal of Pharmacology,
Journal Year:
2025,
Volume and Issue:
995, P. 177414 - 177414
Published: Feb. 20, 2025
Cell
death
occurs
continuously
throughout
individual
development.
By
removing
damaged
or
senescent
cells,
cell
not
only
facilitates
morphogenesis
during
the
developmental
process,
but
also
contributes
to
maintaining
homeostasis
after
birth.
In
addition,
reduces
spread
of
pathogens
by
eliminating
infected
cells.
is
categorized
into
two
main
forms:
necrosis
and
programmed
death.
Programmed
encompasses
several
types,
including
autophagy,
pyroptosis,
apoptosis,
necroptosis,
ferroptosis,
PANoptosis.
Autophagy,
a
mechanism
that
maintains
cellular
equilibrium
via
breakdown
reutilization
proteins
organelles,
implicated
in
regulating
almost
all
forms
pathological
contexts.
Notably,
PANoptosis
are
directly
classified
as
autophagy-mediated
Therefore,
autophagy
presents
therapeutic
approach
for
treating
diseases
such
inflammation
tumors
arise
from
abnormalities
other
This
review
focuses
on
crosstalk
between
modalities,
providing
new
perspectives
clinical
interventions
inflammatory
neoplastic
diseases.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Dec. 13, 2023
Abstract
The
association
between
the
systemic
immune-inflammation
index
(SII)
and
risk
of
sarcopenia
has
not
yet
been
revealed.
purpose
this
study
was
to
investigate
relationship
SII
in
individuals
aged
18–59
years.
All
data
for
are
from
National
Health
Nutrition
Examination
Survey
(NHANES)
database,
including
7258
participants
(age
range:
years).
We
divided
values
by
quartiles
(quartiles
1–4:
0.3–3.1,
3.2–4.4,
4.4–6.2,
6.2–58.5).
constructed
a
multivariate
logistic
regression
model
assess
sarcopenia,
an
interaction
test
run
stability
identify
high-risk
with
sarcopenia.
Compared
nonsarcopenia
participants,
patients
had
significantly
higher
value
(weighted
average:
6.65
vs.
5.16)
(
P
=
0.002).
Multivariate
results
showed
positive
linear
(OR
[odds
ratio]
1.12,
95%
CI
[confidence
interval]
1.03–1.21).
quartile
1
group,
4
group
associated
3.94,
1.42–10.94).
OR
2
groups
upwards
trend
<
0.001)
as
level
increased.
Subgroup
analysis
also
indicate
that
correlation
stable.
There
significant
indicating
can
increase
United
States.
findings
will
be
beneficial
promoting
use
alone
or
combination
other
tools
screening
communities
large
populations.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 6, 2024
Macrophages
play
a
critical
role
in
innate
immunity,
with
approximately
90%
of
the
total
macrophage
population
human
body
residing
liver.
This
encompasses
both
resident
and
infiltrating
macrophages.
Recent
studies
highlight
pivotal
liver
macrophages
various
aspects
such
as
inflammation,
regeneration,
immune
regulation.
A
novel
pro-inflammatory
programmed
cell
death,
pyroptosis,
initially
identified
macrophages,
has
garnered
substantial
attention
since
its
discovery.
Studies
investigating
pyroptosis
inflammation
progression
have
particularly
centered
around
In
diseases,
plays
an
important
driving
inflammatory
response,
facilitating
fibrotic
process,
promoting
tumor
progression.
Notably,
cannot
be
understated.
review
primarily
focuses
on
diseases.
Additionally,
it
underscores
therapeutic
potential
inherent
targeting
pyroptosis.
