Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
ABSTRACT
Oxidative
stress
is
recognized
to
have
a
central
role
in
the
initiation
and
progression
of
Parkinson's
disease
(PD).
Within
brain,
neurons
are
particularly
sensitive
oxidation
due
part
their
weak
intrinsic
antioxidant
defense.
Theoretically,
mostly
depend
on
neighboring
astrocytes
provide
protection
by
supplying
cysteine‐containing
products
for
glutathione
(GSH)
synthesis.
Astrocytes
possess
several
amino
acid
transport
systems
GSH
its
precursors.
Indeed,
most
abundant
nervous
system.
The
depletion
and/or
alterations
metabolism
brain
contribute
pathogenesis
PD.
Noteworthy,
polyphenols
potent
activity
can
augment
redox
Numerous
vitro
vivo
studies
indicated
that
exhibit
neuroprotective
effects
Epidemiological
found
an
association
between
consumption
dietary
lower
PD
risk.
In
this
review,
we
summarize
current
knowledge
biosynthesis
with
emphasis
contribution
therapeutic
potential
particular,
focus
increase
levels
against
Furthermore,
some
challenges
future
perspectives
polyphenol‐based
therapies
also
discussed.
Cellular Reprogramming,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
invasive
brain
tumor,
and
traditional
treatments
combining
surgery
with
radiochemotherapy
have
limited
effects,
tumor
recurrence
being
almost
inevitable.
Given
the
lack
of
proliferative
capacity
in
neurons,
inducing
terminal
differentiation
GBM
cells
or
glioma
stem
(GSCs)
into
neuron-like
has
emerged
as
promising
strategy.
This
approach
aims
to
suppress
their
proliferation
self-renewal
capabilities
through
differentiation.
review
summarizes
methods
involved
recent
research
on
neuronal
GSCs,
including
regulation
transcription
factors,
signaling
pathways,
miRNA,
use
small
molecule
drugs,
among
various
strategies.
It
also
outlines
interconnections
between
mechanisms
studied,
hoping
provide
ideas
for
exploring
new
therapeutic
avenues
development
differentiation-inducing
drugs
GBM.
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Ferroptosis
plays
an
extremely
significant
role
in
the
development
of
hepatocellular
carcinoma
(HCC),
and
targeting
tumor
cells
to
induce
ferroptosis
has
emerged
as
a
new
approach
for
treatment
cancer.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 21, 2025
Glioblastomas
are
the
most
prevalent
primary
brain
tumors
and
associated
with
a
dramatically
poor
prognosis.
Despite
an
intensive
treatment
approach,
including
maximal
surgical
tumor
removal
followed
by
radio-
chemotherapy,
median
survival
for
glioblastoma
patients
has
remained
around
18
months
decades.
Glioblastoma
is
distinguished
its
highly
complex
mechanisms
of
immune
evasion
pronounced
heterogeneity.
This
variability
apparent
both
within
itself,
which
can
exhibit
multiple
phenotypes
simultaneously,
in
surrounding
microenvironment.
Another
key
feature
“cold”
microenvironment,
characterized
robust
immunosuppression.
Recent
advances
single-cell
RNA
sequencing
have
uncovered
new
promising
insights,
revealing
previously
unrecognized
aspects
this
tumor.
In
review,
we
consolidate
current
knowledge
on
cells
emphasis
their
biological
properties
unique
patterns
molecular
communication
through
signaling
pathways.
The
evidence
underscores
critical
need
personalized
poly-immunotherapy
other
approaches
to
overcome
plasticity
stem
cells.
Analyzing
microenvironment
individual
using
transcriptomics
implementing
customized
immunotherapeutic
strategy
could
potentially
improve
outcomes
those
facing
formidable
disease.
