bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Withdrawal
Statement
The
authors
have
withdrawn
their
manuscript
because
Several
expressed
strong
opposition
to
publishing
in
preprint,
as
they
believe
there
are
still
important
details,
key
experiments,
and
additional
tests
needed
complete
the
research.
argue
that
study
is
not
yet
ready
for
publication
investigation
ongoing.
Furthermore,
some
state
did
grant
approval
preprint
therefore
do
authorize
its
release
at
this
stage.
For
these
reasons,
we
kindly
ask
our
requests
be
respected.
Therefore,
wish
work
cited
reference
project.
If
you
any
questions,
please
contact
corresponding
author.
Thank
very
much
your
understanding
cooperation.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 280 - 280
Published: March 7, 2024
Exosomes
are
small
subtypes
of
extracellular
vesicles
(EVs)
naturally
released
by
different
types
cells
into
their
environment.
Their
physiological
roles
appear
to
be
multiple,
yet
many
aspects
biological
activities
remain
understood.
These
can
transport
and
deliver
a
variety
cargoes
may
serve
as
unconventional
secretory
vesicles.
Thus,
they
play
crucial
role
important
vectors
for
intercellular
communication
the
maintenance
homeostasis.
Exosome
production
content
vary
under
several
stresses
or
modifications
in
cell
microenvironment,
influencing
cellular
responses
stimulating
immunity.
During
infectious
processes,
exosomes
described
double-edged
swords,
displaying
both
beneficial
detrimental
effects.
Owing
tractability,
analysis
EVs
from
multiple
biofluids
has
become
booming
tool
monitoring
various
pathologies,
cancerous
origins.
In
this
review,
we
present
an
overview
exosome
features
discuss
particular
ambiguous
functions
contexts.
We
then
focus
on
properties
diagnostic
therapeutic
tools.
regard,
explore
capacity
vectorize
immunogenic
viral
antigens
function
mounting
adaptive
immune
responses.
As
provide
interesting
platforms
antigen
presentation,
further
review
available
data
engineering,
which
enables
peptides
interest
exposed
at
surface.
light
all
these
data,
emerging
promising
avenues
vaccine
strategies.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107179 - 107179
Published: April 13, 2024
Exosomes,
small
yet
vital
extracellular
vesicles,
play
an
integral
role
in
intercellular
communication.
They
transport
critical
components,
such
as
proteins,
lipid
bilayers,
DNA,
RNA,
and
glycans,
to
target
cells.
These
vesicles
are
crucial
modulating
the
matrix
orchestrating
signal
transduction
processes.
In
oncology,
exosomes
pivotal
tumor
growth,
metastasis,
drug
resistance,
immune
modulation
within
microenvironment.
Exosomal
noted
for
their
stability
specificity,
have
garnered
widespread
attention.
This
review
delves
into
mechanisms
of
exosomal
protein
loading
impact
on
development,
with
a
focus
regulatory
effects
natural
products
traditional
Chinese
medicine
function.
insights
not
only
offer
new
strategies
methodologies
cancer
treatment
but
also
provide
scientific
bases
directions
future
clinical
applications.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 14, 2023
Lung
cancer
is
a
chronic
wasting
disease
with
insidious
onset
and
long
treatment
cycle.
Exosomes
are
specialized
extracellular
vesicles,
at
first
exosomes
were
considered
as
transporter
of
cellular
metabolic
wastes,
but
recently
many
studies
have
identified
which
contain
variety
biologically
active
substances
that
play
role
in
the
regulation
communication
physiological
functions.
an
important
development
lung
can
promote
metastasis
through
mechanisms.
However,
same
time,
researchers
also
discovered
immune
cells
inhibit
exosomes.
In
addition,
some
specific
miRNAs
be
used
markers
for
early
diagnosis
cancer.
Engineering
may
one
strategies
to
enhance
clinical
translational
application
future,
example,
such
modifying
targeting
or
utilizing
carriers
drug
delivery
been
explored.
more
needed
verify
safety
efficacy.
This
article
reviews
latest
research
on
field
cancer,
from
mechanism
development,
functions
cell-derived
tumor-derived
exosomes,
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: May 9, 2024
Spinal
cord
injury
(SCI)
remains
a
formidable
challenge,
lacking
effective
treatments.
Following
SCI,
neural
stem
cells
(NSCs)
migrate
to
SCI
sites,
offering
potential
avenue
for
nerve
regeneration,
but
the
effectiveness
of
this
intrinsic
repair
mechanism
suboptimal.
Salidroside
has
demonstrated
pro-repair
attributes
in
various
pathological
conditions,
including
arthritis
and
cerebral
ischemia,
ability
curtail
early-stage
inflammation
following
SCI.
However,
specific
role
salidroside
late-stage
processes
less
defined.
In
investigation,
we
observed
that
continuous
treatment
mice
improved
motor
function
recovery.
Immunofluorescence-staining
corroborated
salidroside's
capacity
stimulate
regeneration
remyelination,
suppress
glial
scar
hyperplasia,
reduce
activation
neurotoxic
A1
astrocytes,
facilitate
NSCs
migration
towards
injured
region.
Mechanistically,
vitro
experiments
elucidated
significant
restraining
astrocyte
proliferation
polarization.
It
was
further
established
astrocytes
hinder
while
inducing
their
differentiation
into
astrocytes.
effectively
ameliorated
inhibition
through
diminishing
c-Jun
N-terminal
kinase
(JNK)
pathway
phosphorylation
restored
neurons
by
suppressing
signal
transducer
activator
transcription
3
(STAT3)
pathway.
summary,
our
findings
suggest
holds
promise
as
therapeutic
agent
traumatic
treatment.
Extracellular Vesicles and Circulating Nucleic Acids,
Journal Year:
2025,
Volume and Issue:
6(2), P. 216 - 44
Published: May 7, 2025
Liver
fibrosis
is
a
progressive
condition
characterized
by
excessive
scar
tissue
buildup,
leading
to
impaired
liver
function
and
potentially
cirrhosis.
Despite
advancements
in
treatment
strategies,
effective
anti-fibrotic
therapies
remain
an
urgent
unmet
need.
Recent
research
has
identified
extracellular
vesicles
(EVs)
as
promising
therapeutic
agents
due
their
ability
mediate
intercellular
communication
regulate
key
fibrotic
pathways.
This
review
aims
provide
comprehensive
overview
of
the
potential
EVs
different
vitro
vivo
models
hepatic
fibrosis,
focusing
on
natural
effects
recent
engineering
for
enhanced
efficacy.
can
be
derived
from
various
cellular
sources,
including
mesenchymal
stromal
cells
(MSCs)
liver-resident
cells.
Biological
materials,
serum,
breast
milk,
bacteria,
plants,
also
serve
EV
sources.
Among
these,
MSC-EVs
stand
out
potential,
which
significantly
through
preconditioning
with
inflammatory
signals,
pharmacological
agents,
or
genetic
improve
quality
Engineering
techniques
have
further
expanded
applications,
enabling
use
precise
drug-delivery
vehicles.
Approaches
such
loading
compounds,
designing
customized
EVs,
creating
EV-liposome
hybrids
enable
targeted
delivery
activated
stellate
(HSCs),
central
drivers
progression.
These
strategies
enhance
efficacy
EV-based
treatments.
Both
engineered
critical
pathways
development,
activation
HSCs,
modulation
pro-fibrotic
genes,
matrix
deposition,
programmed
cell
death.
Additionally,
modulate
immune
responses,
fostering
microenvironment
conducive
repair
regeneration.
Combining
regenerative
properties
innovative
provides
highly
targeted,
approaches
restore
address
need
chronic
disease
therapies.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 14, 2024
Salidroside
(SAL),
a
phenylpropanoid
bioactive
compound,
has
various
pharmacological
properties,
including
antioxidant,
anti-inflammatory,
and
hepatoprotective
effects.
However,
the
effects
mechanisms
of
action
SAL
on
cholestatic
liver
injury
are
unclear.
This
study
investigated
mechanism
salidroside
(SAL)
intestinal
flora
distribution
hepatic
stellate
cell
(HSC)
activation
in
fibrosis.
Bile
duct
ligation
was
used
to
cause
cholestasis
BALB/c
mice.
The
therapeutic
efficacy
fibrosis
assessed
via
serum/tissue
biochemical
analyses
tissue
hematoxylin
eosin
Masson
staining.
Inflammation
oxidative
stress
were
analyzed
using
enzyme-linked
immunosorbent
assay
western
blotting.
HSC
activated
