Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 6, 2024
A growing body of evidence suggests a potential connection between myocardial infarction (MI) and lung cancer (LC). However, the underlying pathogenesis molecular mechanisms remain unclear. This research aims to identify common genes pathways MI LC through bioinformatics analysis.
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 31, 2024
PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.
Language: Английский
Citations
4
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Abstract Inflammasomes trigger cell death upon sensing various intracellular maladies. These supra-structures relay upstream signals by sequentially assembling architecturally congruent filaments via their pyrin domains (PYDs). Interferon Inducible Protein 16 (IFI16) is an innate immune sensor that detects dysregulated nucleic acids. Once presumed as inflammasome receptor due to its PYD, the role of IFI16 has been much more appreciated in other pathways such regulating interferon production and viral replication restriction. Here, a cryo-EM structure filament assembled PYD (PYD) shows helical architecture distinct from filaments. In silico Rosetta interaction energy calculations suggest incompatible with those central adaptor ASC interacting partners. Cellular experiments further support fails interact ASC. Together, we provide structural basis for inflammasome-independent functions IFI16.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.
Language: Английский
Citations
1
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.
Language: Английский
Citations
0
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 6, 2024
A growing body of evidence suggests a potential connection between myocardial infarction (MI) and lung cancer (LC). However, the underlying pathogenesis molecular mechanisms remain unclear. This research aims to identify common genes pathways MI LC through bioinformatics analysis.
Language: Английский
Citations
0