Open Access Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 8(1), P. 1 - 4
Published: Jan. 25, 2024
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 13, 2025
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.
Language: Английский
Citations
26
Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)
Published: March 27, 2025
Abstract Alzheimer’s disease (AD) involves a dynamic interaction between neuroinflammation and metabolic dysregulation, where microglia play central role. These immune cells undergo reprogramming in response to AD-related pathology, with key genes such as TREM2, APOE, HIF-1α orchestrating these processes. Microglial metabolism adapts environmental stimuli, shifting oxidative phosphorylation glycolysis. Hexokinase-2 facilitates glycolytic flux, while AMPK acts an energy sensor, coordinating lipid glucose metabolism. TREM2 APOE regulate microglial homeostasis, influencing Aβ clearance responses. LPL ABCA7, both associated AD risk, modulate processing cholesterol transport, linking neurodegeneration. PPARG further supports by regulating inflammatory Amino acid also contributes function. Indoleamine 2,3-dioxygenase controls the kynurenine pathway, producing neurotoxic metabolites linked pathology. Additionally, glucose-6-phosphate dehydrogenase regulates pentose phosphate maintaining redox balance activation. Dysregulated metabolism, influenced genetic variants APOE4, impair responses exacerbate progression. Recent findings highlight interplay regulators like REV-ERBα, which modulates inflammation, Syk, influences clearance. insights offer promising therapeutic targets, including strategies aimed at modulation, could restore function depending on stage. By integrating metabolic, immune, factors, this review underscores importance of immunometabolism AD. Targeting pathways provide novel for mitigating restoring function, ultimately paving way innovative treatments neurodegenerative diseases.
Language: Английский
Citations
5
Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2519 - 2519
Published: July 11, 2024
Anti-cancer immunotherapies entirely changed the therapeutic approach to oncological patients. However, despite undeniable success of anti-PD-1, PD-L1, and CTLA-4 antibody treatments, their effectiveness is limited either by certain types malignancies or arising problem cancer resistance. B7H4 (aliases B7x, B7H4, B7S1, VTCN1) a member B7 immune checkpoint family with distinct expression pattern from classical pathways. The growing amount research results seem support thesis that might be very potent target. was demonstrated promote tumour progression in "cold" tumours promoting migration, proliferation cells, stem cell persistence. suppresses T effector functions, including inflammatory cytokine production, cytolytic activity, polarisation naïve CD4 cells into induced Tregs. This review aimed summarise available information about focusing particular on clinical implications, immunological mechanisms, potential strategies for malignancy treatment, ongoing trials.
Language: Английский
Citations
3
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118019 - 118019
Published: April 6, 2025
Language: Английский
Citations
0
Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115540 - 115540
Published: April 1, 2025
The DNA-damage response (DDR) is a signaling network that enables cells to detect and repair genomic damage. Over the past three decades, inhibiting DDR has proven be an effective cancer therapeutic strategy. Although drugs targeting have received approval for treating various cancers, tumor often develop resistance these therapies, owing their ability undergo energetic metabolic reprogramming. Metabolic intermediates also influence cells' sense oxidative stress, leading impaired redox metabolism, thus creating vulnerabilities. In this review, we summarize recent advances in understanding crosstalk between metabolism. We discuss combination therapies target DDR, vulnerabilities cancer. outline potential obstacles metabolism propose strategies overcome challenges.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119802 - 119802
Published: April 1, 2025
Language: Английский
Citations
0
European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(5)
Published: May 1, 2025
ABSTRACT In severe malaria, dysregulated metabolism and excessive inflammatory responses contribute to fatal outcomes. Therapeutic strategies that address both metabolic balances are thus required. Itaconate, a metabolite produced by aconitate decarboxylase 1 (ACOD1), is potent inhibitor of inflammation glycolysis with protective effects in various diseases. Although elevated itaconate levels have been observed Plasmodium ‐infected individuals, its role malaria still poorly understood, making further investigation essential for assessing therapeutic potential. We investigated the mild using berghei NK65 ( Pb NK65) chabaudi AS Pc AS) models, respectively. Using 13 C‐tracer metabolomics, we detected increased organs during infection identified monocytes as source this production. Nevertheless, ACOD1 knockout mice displayed no significant changes phenotype after infection, treatment NK65‐infected 4‐octyl did not affect disease severity either. However, model, deficiency worsened disease, indicated weight loss, higher clinical scores, parasitemia. Therefore, contrast findings recent literature, our study shows does susceptibility, but rather provides limited protection malaria.
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: May 29, 2025
Abstract Paediatric bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) comprise significant biological and clinical heterogeneity. This extreme heterogeneity affects response to systemic therapy, facilitates inherent acquired drug resistance possibly underpins the origins of metastatic disease, a key component implicit in cancer related death. Across all cancers, models have offered competing accounts on when dissemination occurs, either early or late during tumorigenesis, whether metastases at different foci arise independently directly from primary tumour give rise each other, i.e. metastases-to-metastases dissemination, cell exchange occurs between synchronously growing lesions. Although it is probable that above mechanisms can lead observations indicate distinct modes metastasis might predominate cancers. Around 70% patients with sarcoma experience their disease course but fundamental molecular underlying spread are equivocal. Newer therapies such as tyrosine kinase inhibitors shown promise reducing relapse trials, nonetheless, not respond 5-year overall survival remains ~ 50%. Better understanding potential subgroups, role immune microenvironment, factors promote biomarkers prognosis required make progress. In this review, we provide comprehensive overview approaches manage paediatric osteosarcoma. We describe basis plasticity, circulating cells development pre-metastatic niche, for successful distant colonisation. Finally, discuss ongoing upcoming patient gene regulatory networks amenable anti-metastasis medicines.
Language: Английский
Citations
0
Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101590 - 101590
Published: June 24, 2024
Food processing transforms raw materials into different food forms using physical or chemical techniques. Recently, carbohydrates have gained attention for their diverse biological activities like antioxidant, anticancer, and antimutagenic effects. Selecting suitable methods is crucial to preserve the beneficial properties of carbohydrates. This review discusses impact non-thermal thermal on physicochemical traits carbohydrates, highlighting need understanding mechanisms underlying these changes. Future research will focus enhancing safeguarding functional aspects through improved The goal optimize that maintain maximizing health benefits consumers.
Language: Английский
Citations
2