Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(12), P. 1599 - 1599
Published: Nov. 27, 2024
Endoplasmic
reticulum
(ER)
stress
and
the
unfolded
protein
response
(UPR)
play
critical
roles
in
tumorigenesis,
cancer
progression,
drug
resistance.
Persistent
activation
of
ER
system
enhances
survival
capacities
malignant
tumor
cells,
including
increased
proliferation,
invasion,
resistance
to
treatment.
Dysregulation
function
resultant
is
a
common
cellular
therapies
may
lead
cell
death.
Currently,
growing
evidence
suggests
that
Traditional
Chinese
medicine
(TCM),
either
as
monotherapy
or
combination
with
other
treatments,
offers
significant
advantages
preventing
cancer,
inhibiting
growth,
reducing
surgical
complications,
improving
sensitivity,
mitigating
drug-induced
damage.
Some
these
natural
products
have
even
entered
clinical
trials
primary
complementary
anticancer
agents.
In
this
review,
we
summarize
effects
TCM
monomers/natural
on
gastrointestinal
(GI)
tumors
explore
their
mechanisms
through
modulation.
We
believe
ongoing
laboratory
research
development
TCM-based
hold
considerable
potential
for
advancing
future
treatments.
npj Systems Biology and Applications,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 13, 2025
Cancer
metabolism
is
characterized
by
significant
heterogeneity,
presenting
challenges
for
treatment
efficacy
and
patient
outcomes.
Understanding
this
heterogeneity
its
regulatory
mechanisms
at
single-cell
resolution
crucial
developing
personalized
therapeutic
strategies.
In
study,
we
employed
a
network
approach
to
characterize
malignant
in
gynecologic
breast
cancers,
focusing
on
the
transcriptional
driving
metabolic
alterations.
By
leveraging
RNA
sequencing
(scRNA-seq)
data,
assessed
pathway
activities
inferred
cancer-specific
protein-protein
interactomes
(PPI)
gene
networks
(GRNs).
We
explored
crosstalk
between
these
identify
key
alterations
regulation.
Clustering
cells
pathways
revealed
tumor
across
highlighting
variations
oxidative
phosphorylation,
glycolysis,
cholesterol,
fatty
acid,
hormone,
amino
redox
metabolism.
Our
analysis
identified
modules
associated
with
pathways,
along
their
regulators.
These
findings
provide
insights
into
complex
interplay
rewiring
regulation
paving
way
potential
targeted
strategies
precision
oncology.
Furthermore,
pipeline
dissecting
coregulatory
can
be
broadly
applied
decipher
any
disease
resolution.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 19, 2025
Abstract
Extracellular
vesicles
(EVs)
are
emerging
as
critical
mediators
of
intercellular
communication
in
the
tumor
microenvironment
(TME),
profoundly
influencing
cancer
progression.
These
nano-sized
vesicles,
released
by
both
and
stromal
cells,
carry
a
diverse
cargo
proteins,
nucleic
acids,
lipids,
reflecting
dynamic
cellular
landscape
mediating
intricate
interactions
between
cells.
This
review
provides
comprehensive
overview
biogenesis,
composition,
functional
roles
EVs
cancer,
highlighting
their
significance
basic
research
clinical
applications.
We
discuss
how
cells
manipulate
EV
biogenesis
pathways
to
produce
enriched
with
pro-tumorigenic
molecules,
explore
specific
contributions
key
hallmarks
such
angiogenesis,
metastasis,
immune
evasion,
emphasizing
role
shaping
TME
driving
therapeutic
resistance.
Concurrently,
we
submit
recent
knowledge
on
can
serve
valuable
source
biomarkers
for
minimally
invasive
liquid
biopsies,
its
potential,
particularly
targeted
drug
delivery
vehicles
immunomodulatory
agents,
showcasing
promise
enhancing
efficacy
safety
treatments.
By
deciphering
messages
carried
EVs,
gain
deeper
understanding
biology
develop
more
effective
strategies
early
detection,
therapy,
immunotherapy,
paving
way
new
era
personalized
precise
medicine
potential
significantly
improve
patient
outcomes.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(4), P. 221 - 221
Published: March 24, 2025
Background/Objectives:
Endoplasmic
reticulum
(ER)
stress
occurs
when
ER
homeostasis
is
disrupted,
leading
to
the
accumulation
of
misfolded
or
unfolded
proteins.
This
condition
activates
protein
response
(UPR),
which
aims
restore
balance
trigger
cell
death
if
cannot
be
achieved.
In
cancer,
plays
a
key
role
due
heightened
metabolic
demands
tumor
cells.
review
explores
how
metabolomics
can
provide
insights
into
stress-related
alterations
and
their
implications
for
cancer
therapy.
Methods:
A
comprehensive
literature
was
conducted
analyze
recent
findings
on
stress,
metabolomics,
metabolism.
Studies
examining
profiling
cells
under
conditions
were
selected,
with
focus
identifying
potential
biomarkers
therapeutic
targets.
Results:
Metabolomic
studies
highlight
significant
shifts
in
lipid
metabolism,
synthesis,
oxidative
management
stress.
These
are
crucial
adaptation
survival.
Additionally,
targeting
pathways
has
shown
preclinical
models,
suggesting
new
strategies.
Conclusions:
Understanding
impact
provides
valuable
opportunities
drug
development.
Metabolomics-based
approaches
may
help
identify
novel
targets,
enhancing
effectiveness
antitumor
therapies.
Cancer Biology & Therapy,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: April 1, 2025
Endoplasmic
reticulum
stress
(ERS)
has
been
implicated
in
the
pathogenesis
of
various
cancers,
including
colon
cancer,
by
regulating
tumor
cell
survival,
growth,
and
immune
response.
However,
specific
genes
involved
ERS
that
could
serve
as
prognostic
markers
cancer
remain
underexplored.
This
study
aims
to
identify
validate
endoplasmic
related
(ERSRGs)
correlate
with
patient
prognosis,
thereby
enhancing
understanding
oncological
outcomes
potential
therapeutic
targeting.
We
utilized
bioinformatics
analyses
ERSRGs
from
publicly
available
datasets.
Differential
expression
analysis
survival
were
performed
assess
significance
these
genes.
Validation
was
conducted
through
quantitative
real-time
PCR
(RT-qPCR)
on
selected
lines.
Our
identified
nine
(ASNS,
ATF4,
ATF6B,
BOK,
CLU,
DDIT3,
MANF,
SLC39A14,
TRAF2)
critical
pathways
IL-12,
PI3K-AKT,
IL-7,
IL-23
signaling,
linked
1-,
3-,
5-year
patients
cancer.
A
multivariate
Cox
model
based
demonstrated
significant
power.
Further,
TRAF2
strong
correlated
cells
infiltration,
suggesting
its
roles
modulating
responses
microenvironment.
The
RT-qPCR
validation
confirmed
differential
human
lines
versus
normal
colonic
epithelial
line.
valuable
may
offer
new
insights
into
targeting
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Abstract
Colorectal
cancer
(CRC)
remains
a
leading
cause
of
cancer-related
mortality
worldwide.
Natural
compounds
with
anticancer
potential,
such
as
tomentosin,
sesquiterpene
lactone
derived
from
Inula
viscosa
,
are
under
investigation
alternative
therapeutic
agents.
However,
its
potential
effects
on
CRC
remain
unexplored.
This
study
aimed
to
evaluate
the
tomentosin
in
cells
and
elucidate
underlying
molecular
mechanisms.
HCT
116
HT-
29
were
treated
cell
viability,
colony
formation,
invasion,
apoptosis,
mitochondrial
membrane
(MMP),
reactive
oxygen
species
(ROS)
production,
autophagy,
endoplasmic
reticulum
(ER)
stress
evaluated.
Various
assays,
including
XTT,
Matrigel
invasion
used
assess
proliferation,
invasion.
Tomentosin
markedly
reduced
viability
formation
dose-dependent
manner.
It
suppressed
induced
evidenced
by
an
increased
apoptotic
index
upregulation
CASP3
CASP7
CASP8
CASP9
BAX
.
disrupted
MMP
elevated
ROS
levels,
contributing
signaling.
Autophagic
activity
was
significantly
upregulated,
expression
BECLIN1
ATG5
ATG7
MAP1LC3
A
ER
markers
GRP78
ATF6
CHOP
XBP1
also
suggesting
role
death.
has
inducing
modulating
triggering
stress.
These
findings
underscore
tomentosin’s
novel
candidate
for
CRC,
warranting
further
vivo
clinical
investigations.
