Mechanistic insights from inflammasome structures

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(7), P. 518 - 535

Published: Feb. 19, 2024

Language: Английский

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Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 545 - 545

Published: Feb. 13, 2023

Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant (Rosmarinus officinalis). They possess a phenolic structural moiety endowed with power to remove cellular reactive oxygen species (ROS) either through direct scavenging reaction or indirectly upregulation antioxidant defences. Hand in hand these activities their multiple biological effects therapeutic potential orchestrated modulating various signalling pathways inflammation, including NF-κB, MAPK, Nrf2, SIRT1, STAT3 NLRP3 inflammasomes, among others. Consequently, they ameliorate expression pro-inflammatory cytokines (e.g., TNF-α, IL-1 IL-6), adhesion molecules, chemokines prostaglandins. These anti-inflammatory mechanisms action as link compounds, many other natural products, scrutinised.

Language: Английский

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Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 51(4)

Published: March 21, 2023

The inflammasome regulates innate immunity by serving as a signaling platform. Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor apoptosis‑associated speck‑like (ASC) and pro‑caspase‑1, is far most extensively studied well‑characterized inflammasome. A variety of stimuli can activate NLRP3 When activated, recruits ASC activates resulting in inflammatory cytokine maturation secretion, which associated inflammation pyroptosis. However, aberrant activation has been linked to various diseases, including atherosclerosis, ischemic stroke, Alzheimer's disease, diabetes mellitus bowel disease. Therefore, emerged promising therapeutic target for diseases. In present review, systematic searches were performed using 'NLRP3 inhibitor(s)' 'inflammatory disease(s)' key words. By browsing literature from 2012 2022, 100 articles retrieved, 35 excluded they reviews, editorials, retracted or unavailable online, 65 included. According retrieved literature, current understanding pathway diseases was summarize, inhibitors targeting other components products highlighted. Additionally, review briefly discusses novel efforts clinical research.

Language: Английский

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The Matrix-M™ adjuvant: A critical component of vaccines for the 21 ^st century

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(1)

Published: Jan. 2, 2023

Matrix-M™ adjuvant is a key component of several novel vaccine candidates. The Matrix-M consists two distinct fractions saponins purified from the Quillaja saponaria Molina tree, combined with cholesterol and phospholipids to form 40-nm open cage-like nanoparticles, achieving potent adjuvanticity favorable safety profile. induces early activation innate immune cells at injection site in draining lymph nodes. This translates into improved magnitude quality antibody response antigen, broadened epitope recognition, induction Th1-dominant response. Matrix-M-adjuvanted vaccines have profile are well tolerated clinical trials. In this review, we discuss latest findings on mechanisms action, efficacy, other saponin-based adjuvants, focus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit candidate NVX-CoV2373 developed prevent disease 2019 (COVID-19).

Language: Английский

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Inflammasomes in neurological disorders — mechanisms and therapeutic potential

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 67 - 83

Published: Jan. 9, 2024

Language: Английский

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