Autophagy in inflammation, infection, and immunometabolism

Immunity, Journal Year: 2021, Volume and Issue: 54(3), P. 437 - 453

Published: March 1, 2021

Language: Английский

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Targeting lysosomes in human disease: from basic research to clinical applications

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Nov. 8, 2021

Abstract In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes dysfunction have been correlated with development numerous diseases. this review, we interpreted key biological functions four areas: metabolism, cell proliferation differentiation, immunity, death. More importantly, actively sought to determine characteristic cells affected by these diseases, causes dysfunction, their significance treatment human disease. Furthermore, outlined currently available targeting strategies: (1) lysosomal acidification; (2) cathepsins; (3) membrane permeability integrity; (4) calcium signaling; (5) mTOR (6) emerging potential strategies. Moreover, systematically summarized corresponding drugs application clinical trials. By integrating basic research findings, discussed current opportunities challenges

Language: Английский

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Impact of intracellular innate immune receptors on immunometabolism

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 19(3), P. 337 - 351

Published: Oct. 25, 2021

Abstract Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has gained importance as a regulator homeostasis, proliferation, differentiation innate adaptive subsets that function key factors in immunity. Metabolic changes epithelial other stromal cells response to different stimulatory signals are also crucial infection, inflammation, cancer, autoimmune diseases, disorders. The crosstalk between PI3K–AKT–mTOR LKB1–AMPK signaling pathways critical for modulating both nonimmune metabolism. bidirectional interaction metabolism topic intense study. Toll-like receptors (TLRs), cytokine receptors, T B have been shown activate multiple downstream pathways. However, how intracellular sensors/receptors intersect with less well understood. goal this review examine link immunometabolism functions several sensors or such nucleotide-binding leucine-rich repeat-containing (NLRs, NOD-like receptors), absent melanoma 2 (AIM2)-like (ALRs), cyclic dinucleotide receptor stimulator interferon genes (STING). We will focus on recent advances describe impact these Whenever appropriate, provide brief contextual connection pathogenic infections, cancers, disorders, and/or inflammatory bowel diseases.

Language: Английский

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Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 429, P. 128332 - 128332

Published: Jan. 25, 2022

Language: Английский

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Protein synthesis, degradation, and energy metabolism in T cell immunity

Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(3), P. 303 - 315

Published: Jan. 4, 2022

T cell activation, proliferation, and differentiation into effector memory states involve massive remodeling of size molecular content create a increase in demand for energy amino acids. Protein synthesis is an energy- resource-demanding process; as such, changes production are intrinsically linked to proteome remodeling. In this review, we discuss how protein degradation change over the course immune response crosstalk between these processes metabolism. We highlight use high-resolution mass spectrometry analyze proteomes can improve our understanding regulated.

Language: Английский

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Immunotoxicity responses to polystyrene nanoplastics and their related mechanisms in the liver of zebrafish (Danio rerio) larvae

Environment International, Journal Year: 2022, Volume and Issue: 161, P. 107128 - 107128

Published: Feb. 5, 2022

Nanoplastics in aquatic environments may induce adverse immunotoxicity effects fish. However, there is insufficient evidence on the visible endpoints larval stages of The liver plays an important role systemic and local innate immunity In this study, hepatic inflammatory polystyrene (PS) nanoplastic particles (NPs: 100 50 nm) micron PS transgenic zebrafish (Danio rerio) larvae were estimated using fluorescent-labeled neutrophils, macrophages, liver-type binding protein (fabp10a). Particles with smaller size induced higher aggregations neutrophils apoptosis macrophages abdomen larvae, corresponding to greater inflammation larvae. NPs increased expression fabp10a livers a dose- size-dependent manner. nm at concentration 0.1 mg·L−1 by 21.90% (P < 0.05). plausible mechanisms these depend their distribution generation reactive oxygen species Metabonomic analysis revealed that metabolic pathways catabolic processes, amino acids, purines highly promoted NPs, compared particles. also activate steroid hormone biosynthesis which lead occurrence immune-related diseases. For first time, was identified as target organ for stage

Language: Английский

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Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune non-autoimmune mediated. The immune system regulates functioning cellular within organs like brain, pancreas and/or adipose tissue by sensing adapting to fluctuations microenvironment’s nutrients, thereby reshaping metabolic pathways that greatly impact pro- or anti-inflammatory immunophenotype. While it is agreed relies on an adequate nutritional status function properly, we are only just starting understand how supply single combined all them termed immunonutrients, can steer cells towards less inflamed, tolerogenic Polyphenols, class secondary metabolites abundant Mediterranean foods, pharmacologically active natural products with outstanding immunomodulatory actions. Upon binding range receptors highly expressed (e.g. AhR, RAR, RLR), they act through mitochondria-centered multi-modal approach. First , polyphenols activate nutrient via stress-response pathways, essential for responses. Second regulate mammalian target rapamycin (mTOR)/AMP-activated protein kinase (AMPK) balance well-tolerated caloric restriction mimetics. Third interfere assembly NLR family pyrin domain containing 3 (NLRP3) endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis autophagosome-lysosome fusion. Finally chromatin remodeling coordinates epigenetic reprogramming. This work moves beyond well-documented antioxidant properties polyphenols, offering new insights into multifaceted nature these compounds. It proposes mechanistical appraisal regulatory which modulate response, alleviating low-grade inflammation. Furthermore, draws parallels pharmacological interventions polyphenol-based immunonutrition their modes immunomodulation across spectrum socioeconomically impactful diseases such as Multiple Sclerosis, Diabetes (type 1 2) even Alzheimer’s disease. Lastly, discusses existing challenges thwart translation polyphenols-based immunonutritional long-term clinical studies. Overcoming limitations will undoubtedly pave way precision nutrition protocols provide personalized guidance tailored plans.

Language: Английский

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Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2553 - 2582

Published: March 4, 2024

The intricate and complex features of enzymatic reaction networks (ERNs) play a key role in the emergence sustenance life. Constructing such vitro enables stepwise build up complexity introduces opportunity to control activity using physicochemical stimuli. Rational design modulation network motifs enable engineering artificial systems with emergent functionalities. Such functional are useful for variety reasons as creating new-to-nature dynamic materials, producing value-added chemicals, constructing metabolic modules synthetic cells, even enabling molecular computation. In this review, we offer insights into chemical characteristics ERNs while also delving their potential applications associated challenges.

Language: Английский

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AMPK–a key factor in crosstalk between tumor cell energy metabolism and immune microenvironment?

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 18, 2024

Abstract Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune tolerance, immunosuppressive environment, tumor heterogeneity, escape, and other factors, the efficacy of immunotherapy been limited with its application very small population size. Energy metabolism not only affects progression but also plays a crucial role escape. Tumor cells are more metabolically active need energy nutrients maintain their growth, which causes surrounding lack glucose, oxygen, nutrients, result decreased cell activity increased cells. On hand, utilize multiple metabolic pathways, for instance, cellular respiration, oxidative phosphorylation pathways normal function. Studies have shown that there is difference expenditure resting activated states. Notably, competitive uptake glucose main cause impaired T Conversely, glutamine competition often activation most transformation CD4 + into inflammatory subtypes. Excessive metabolite lactate impairs function NK Furthermore, PGE2 inhibits response by inhibiting Th1 differentiation, B function, activation. Additionally, tumor-suppressive M1 macrophages cancer-promoting M2 influenced metabolism. Therefore, vital factor involved reconstruction microenvironment. Noteworthy does program affect antigen presentation recognition cells, own functions, ultimately leading changes Metabolic intervention can improve tumors, increase immunogenicity thereby expanding who benefit from immunotherapy. Consequently, identifying crosstalk molecules link microenvironment would be promising anti-tumor strategy. AMPK (AMP-activated protein kinase) ubiquitous serine/threonine kinase eukaryotes, serving central regulator pathways. The sequential associated signaling cascades profoundly impacts dynamic alterations bioenergetics. By modulating responses, exerts influence on development, while playing pivotal regulating AMPK-mediated facilitates recruitment (TIME), impeding tumorigenesis, progression, metastasis. AMPK, between homeostasis, bioenergetics, immunity, will impact treatment management oncology patients. That being summarized, objective review pinpoint provide guidance development strategies.

Language: Английский

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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 27, 2025

Language: Английский

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