Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

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Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 670 - 670

Published: May 22, 2024

Given the ongoing rise in occurrence of allergic disorders, alterations dietary patterns have been proposed as a possible factor contributing to emergence and progression these conditions. Currently, there is significant focus on development therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols plant metabolites intensively researched due their well-documented anti-inflammatory, antioxidant, immunomodulatory characteristics, making them one most prominent bioactive chemicals. This study seeks discuss in-depth mechanisms by which molecules may exert anti-allergic effects, namely through capacity diminish allergenicity proteins, modulate immune responses, modify composition gut microbiota. However, further investigation required fully understand effects. paper examines existing evidence from experimental clinical studies supports idea different polyphenols, such catechins, resveratrol, curcumin, quercetin, others, can reduce inflammation, relieve symptoms food allergy, asthma, atopic dermatitis, rhinitis, prevent response. In summary, possess properties be utilized for developing both preventative therapeutic strategies targeting The also discusses constraints investigating broad usage well potential avenues future research.

Language: Английский

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Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 723 - 723

Published: Feb. 20, 2025

Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.

Language: Английский

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Small Phenolic Metabolites at the Nexus of Nutrient Transport and Energy Metabolism

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1026 - 1026

Published: Feb. 24, 2025

Over time, human metabolism evolved to accommodate the challenges and benefits of plant foods that contain high amounts carbohydrates polyphenols. The latter are typically metabolized into small phenolic metabolites, including acids their endogenous microbial derivatives, influence interconnected metabolic pathways involved in nutrient transport, energy metabolism, neurotransmitter balance. Unlike other natural products, biological effects arise from weak interactions with multiple molecular rather than a single high-affinity receptor, making them versatile regulators health. These compounds also modulate glucose transporters carbohydrate playing crucial role postprandial insulin responses. This review addresses critical metabolites health, focus on homeostasis, sensitivity, metabolism. Incorporating polyphenols dietary strategies offers significant potential for improving reducing disorder risks, promoting whole-body homeostasis. Furthermore, understanding how interact is essential developing future effective nutritional support

Language: Английский

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Serum Maresin-1 and Resolvin-D1 Levels as Non-Invasive Biomarkers for Monitoring Disease Activity in Ulcerative Colitis

Diagnostics, Journal Year: 2025, Volume and Issue: 15(7), P. 834 - 834

Published: March 25, 2025

Background: Specialized pro-resolving lipid mediators (SPMs), such as maresins and resolvins, play a key role in resolving inflammation repairing tissues. This study aimed to evaluate whether maresin-1 (MaR1) resolvin-D1 (RvD1) could serve serum non-invasive biomarkers for monitoring disease activity ulcerative colitis (UC). Methods: cross-sectional included 60 UC patients (30 active, 30 remission) healthy controls. Disease was assessed using the Mayo Endoscopic Subscore (MES). Inflammatory indices, including neutrophil-lymphocyte ratio (NLR), monocyte-HDL cholesterol (MHR), platelet-lymphocyte (PLR), CRP-lymphocyte (CLR), CRP-albumin (CAR), systemic response index (SIRI), immune-inflammation (SII), were calculated. Plasma MaR1 RvD1 levels measured via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) analysis performed biomarker accuracy. Results: CRP, NLR, PLR, CLR, CAR, SIRI, SII significantly elevated active UC, whereas lower compared remission controls (p < 0.05). group than ROC demonstrated high area under curve (AUC) values (0.906), CAR (0.872), CLR (0.861), CRP (0.858) distinguishing from remission, (0.944), (0.939), (0.928), (0.889) The specificity detecting 60% 80% RvD1. Both showed negative correlation with MES, demonstrating stronger (r = -0.754, p 0.001). Conclusions: shows strong severity colitis, while low may indicate subclinical inflammation. Although are not disease-specific, their resolution suggests they complement conventional inflammatory markers more comprehensive monitoring.

Language: Английский

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Why Is the Association Between Mediterranean Diet and Physical Performance in Athletes Inconclusive? Implications for Future Studies

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 16 - 16

Published: Jan. 2, 2025

Background/Objectives: Athletes increasingly turn to nutrition and supplements enhance performance, yet the evidence surrounding efficacy of Mediterranean diet (MD) remains inconclusive. This scoping review aims evaluate identify gaps in existing literature provide implications for future research on MD’s potential improve athletic performance across various demographics, sport types, measures. Methods: We conducted a systematic search peer-reviewed studies published four databases (PubMed, Scopus, Scielo, Google Scholar) using following terms their combinations: “mediterranean diet”, “performance”, “athlete”, “sport”. The placed no restrictions experimental design or time period publication focused athletes regardless competitive level. examined targeted about effects key metrics, such as endurance, strength, speed, while also evaluating possible confounding factors like dietary intake, body composition, training status. further aimed by investigating consistency dosing protocols, supplementation duration, methodologies used. Results: preliminary findings suggest that some report benefits MD recovery only 40% show statistically significant improvements outcomes, often with methodological limitations. lacked homogeneity participant dosage, assessments, hindering comparability. Our highlights need incorporates standardized dosing, homogeneous athlete populations, controlled conditions. Conclusions: provides framework guide offers insights into role sports nutrition.

Language: Английский

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A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 53 - 53

Published: Jan. 5, 2025

Investigating amyloid-β (Aβ) peptides in solution is essential during the initial stages of developing lead compounds that can influence Aβ fibrillation while peptide still a soluble state. The tendency Aβ(1-42) to misfold solution, correlated aetiology Alzheimer's disease (AD), one main hindrances characterising its aggregation kinetics cell-mimetic environment. Moreover, triggers unfolded protein response (UPR) endoplasmic reticulum (ER), leading cellular dysfunction and multiple cell death modalities, exacerbated by reactive oxygen species (ROS), which damage components trigger inflammation. Antioxidants like curcumin, derivative Curcuma longa, help mitigate ER stress scavenging ROS enhancing antioxidant enzymes. Furthermore, evidence literature highlights effect curcumin on secondary structure Aβ(1-42). This explorative study investigates conformational behaviour presence six derivatives using circular dichroism (CD) explore their interactions with lipid bilayers, potentially preventing aggregate formation. results suggest synthetic tetrahydrocurcumin (THC) interacts amyloid all systems presented, cyclocurcumin (CYC) bisdemethoxycurcumin (BMDC) only interact when less stable conformation. Molecular dynamics simulations helped visualise curcuminoids' an aqueous system hypothesise importance surface exposition solvent, differently modulated derivatives.

Language: Английский

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Enhancing the Implant Osteointegration via Supramolecular Co‐Assembly Coating with Early Immunomodulation and Cell Colonization

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone‐related immunomodulation cellular colonization play crucial roles, but have received limited attention. Herein, novel supramolecular co‐assembled coating strontium (Sr)‐doped metal polyphenol networks (MPN) modified with c(RGDfc) developed well‐characterized, for eliciting early colonization. results showed that (Sr‐MPN)@RGD significantly regulated polarization macrophages to M2 phenotype by controllable release Sr, promote adhesion marrow mesenchymal stem cells (BMSCs) RGD presented on MPN. Notably, attenuated osteoclast differentiation oxidative stress as well enhanced osteoblast angiogenesis due macrophage toward phenotype, which in turn has profound effect neighboring through paracrine signaling. In vivo manifested superior osseointegration maturation bare Ti‐rod or coated MPN Sr‐MPN. This work contributed design multifunctional coatings address complex process osteointegration from perspective orchestrating cell recruitment immunomodulatory strategies.

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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The Effects of Fisetin on Gene Expression Profile and Cellular Metabolism in IFN-γ-Stimulated Macrophage Inflammation

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 182 - 182

Published: Feb. 4, 2025

Although interferon-gamma (IFN-γ) is known as a critical factor in polarizing macrophages into the pro-inflammatory state for immune response, how dietary flavonoids regulate IFN-γ response anti-inflammation incompletely elucidated. This study aims to investigate effect of fisetin, typical flavonol, on inhibition IFN-γ-induced inflammation by RNA sequencing (RNA-Seq) and cellular metabolism analysis. RAW264 pretreated with fisetin following stimulation were subjected RNA-Seq analyze alterations gene expression. Cellular signaling transcription investigated using enrichment analysis, motif prediction. metabolic was assessed measuring oxygen consumption rate (OCR) lactate level reflect mitochondrial respiration glycolysis. Alterations proteins confirmed Western blot. The results revealed that downregulated expression genes M1 marker such Cxcl9, Il6, Cd80, Cd86, Nos2. In metabolism, upregulated oxidative phosphorylation (OXPHOS) pathway, restored impaired OCR, reduced production induced IFN-γ. Motif analysis suggested suppressed activation IFN-regulatory 1 (IRF1). blot data further inhibited Jak1, Jak2, STAT1, decreased nuclear accumulation phosphorylated STAT1 IRF1 Taken together, our potent flavonoid attenuates IFN-γ-stimulated murine macrophage ameliorates disrupted possible Jak1/2-STAT1-IRF1 pathway.

Language: Английский

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