Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis DOI Open Access
Shupeng Liu,

Yinyun Deng,

Hui Liu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2433 - 2433

Published: July 26, 2024

Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore relationship between intake aging-related phenotypes. employed Mendelian randomization (MR) select genetic variants associated with from large genomic databases, ensuring independence pleiotropy-free nature these instrumental variables (IVs), calculated F-statistic evaluate strength IVs. The validity estimates was assessed through sensitivity analyses various MR methods (MR-Egger, weighted median, inverse-variance (IVW), simple mode, mode), MR-Egger regression intercept used test for pleiotropy bias Cochran's Q heterogeneity results. findings reveal a positive consumers DNA methylation PhenoAge acceleration, suggesting increased may accelerate biological aging process. Specifically, lamb is found effect mitochondrial copy number, while processed consumption shows negative telomere length. No significant were observed other intake. highlights impact processing cooking meat's role in enhancing our understanding how their preparation affect process, providing theoretical basis dietary strategies at delaying quality life.

Language: Английский

The interplay between DNA and histone methylation: molecular mechanisms and disease implications DOI Open Access
Yinglu Li, Xiao Chen, Chao Lü

et al.

EMBO Reports, Journal Year: 2021, Volume and Issue: 22(5)

Published: April 12, 2021

Language: Английский

Citations

155
Dnmt1 has de novo activity targeted to transposable elements DOI Creative Commons

Chuck Haggerty,

Helene Kretzmer, Christina Riemenschneider

et al.

Nature Structural & Molecular Biology, Journal Year: 2021, Volume and Issue: 28(7), P. 594 - 603

Published: June 17, 2021

DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian landscape is dependent on the combined activities of canonical maintenance enzyme Dnmt1 and de novo Dnmts, 3a 3b. Here, we demonstrate that displays activity vitro vivo with specific retrotransposon targeting. We used whole-genome bisulfite long-read Nanopore sequencing genetically engineered methylation-depleted mouse embryonic stem cells to provide an in-depth assessment quantification this activity. Utilizing additional knockout lines molecular characterization, show depends Uhrf1, its genomic recruitment overlaps regions enrich for Trim28 H3K9 trimethylation. Our data can catalyze both context, especially at retrotransposons, where mechanism may stability long-term repression epigenetic propagation throughout development.

Language: Английский

Citations

127
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer DOI
Isaac F. López-Moyado, Myunggon Ko, Patrick G. Hogan

et al.

Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 455 - 488

Published: Feb. 16, 2024

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) 5-carboxylcytosine (5caC). All three epigenetic modifications intermediates in DNA demethylation. TET recruited by transcription factors RNA polymerase II modify 5mC at enhancers gene bodies, thereby regulating expression during development, cell lineage specification, activation. It is not yet clear, however, how established biochemical activities enzymes oxidizing mediating demethylation relate known association deficiency with inflammation, clonal hematopoiesis, cancer. There hints ability promote proliferation a signal-dependent manner may be harnessed for cancer immunotherapy. In this review, we draw upon recent findings cells immune system illustrate as well emerging ideas influence cellular function.

Language: Английский

Citations

26
Emerging epigenetic insights into aging mechanisms and interventions DOI
Zeming Wu, Weiqi Zhang, Jing Qu

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(2), P. 157 - 172

Published: Jan. 11, 2024

Language: Английский

Citations

22
Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions DOI
Huatao Zhou,

Zilong Zheng,

Chengming Fan

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 44 - 66

Published: Jan. 9, 2025

Language: Английский

Citations

3
Interplay between chromatin marks in development and disease DOI
Sanne Janssen, Matthew C. Lorincz

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 23(3), P. 137 - 153

Published: Oct. 4, 2021

Language: Английский

Citations

104
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals DOI Creative Commons
Nataliya Petryk, Sebastian Bultmann, Till Bartke

et al.

Nucleic Acids Research, Journal Year: 2020, Volume and Issue: 49(6), P. 3020 - 3032

Published: Nov. 11, 2020

Abstract DNA methylation is essential to development and cellular physiology in mammals. Faulty frequently observed human diseases like cancer neurological disorders. Molecularly, this epigenetic mark linked other chromatin modifications it regulates key genomic processes, including transcription splicing. Each round of replication generates two hemi-methylated copies the genome. These must be converted back symmetrically methylated before next S-phase, or will fade away; therefore maintenance essential. Mechanistically, modification takes place during after replication, occurs within very dynamic context re-assembly. Here, we review recent discoveries unresolved questions regarding mechanisms, dynamics fidelity We also discuss how could regulated normal misregulated disease.

Language: Английский

Citations

102
The Role of microRNAs in Organismal and Skin Aging DOI Open Access
Marta Gerasymchuk,

Viktoriia Cherkasova,

Olga Kovalchuk

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(15), P. 5281 - 5281

Published: July 25, 2020

The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself with a decline in an organism's ability to adapt is linked development of age-related diseases that eventually lead premature death. This review aims explore how microRNAs (miRNAs) are involved skin functioning aging. Recent evidence has suggested miRNAs regulate all aspects cutaneous biogenesis, functionality, It been noted some were down-regulated long-lived individuals, such as let-7, miR-17, miR-34 (known longevity-related miRNAs). They conserved humans presumably promote lifespan prolongation; conversely, they up-regulated diseases, like cancers. analysis age-associated revealed increased expression miR-130, miR-138, miR-181a/b keratinocytes during replicative senescence. These affected cell proliferation pathways via targeting p63 Sirtuin 1 mRNAs. Notably, miR-181a was also implicated immunosenescence, represented by Langerhans cells. Dermal fibroblasts expressed levels biomarkers affect telomere maintenance phases cellular life cycle, miR-23a-3p, 34a-5p, miR-125a, miR-181a-5p, miR-221/222-3p. Among them, family, stimulated ultraviolet B irradiation, deteriorates collagen extracellular matrix due activation metalloproteinases thereby potentiates wrinkle formation. In addition pro-aging effects miRNAs, plausible antiaging activity miR-146a antagonized UVA-induced inhibition suppressed aging-related genes (e.g., p21WAF-1, p16, p53) through Smad4 noticed. Nevertheless, role still not fully elucidated needs be further discovered explained.

Language: Английский

Citations

84
The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity DOI Creative Commons
Monica Mancini, Elena Magnani, Filippo Macchi

et al.

Nucleic Acids Research, Journal Year: 2021, Volume and Issue: 49(11), P. 6053 - 6068

Published: April 12, 2021

Abstract During S phase, the cooperation between macromolecular complexes regulating DNA synthesis, epigenetic information maintenance and repair is advantageous for cells, as they can rapidly detect damage initiate response (DDR). UHRF1 a fundamental regulator; its ability to coordinate methylation histone code unique across proteomes of different species. Recently, UHRF1’s role in has been explored recognized be important maintaining epigenome. sensor interstrand crosslinks determinant switch towards homologous recombination double-strand breaks; loss results enhanced sensitivity damage. These functions are finely regulated by specific post-translational modifications mediated SRA domain, which binds damaged DNA, RING domain. Here, we review recent studies on DDR focusing how it recognizes cooperates with other proteins repair. We then discuss abilities reading writing modifications, or interactions ncRNAs, could interlace DDR.

Language: Английский

Citations

68
Epigenetic clocks, aging, and cancer DOI

Sarah E. Johnstone,

Vadim N. Gladyshev, Martin J. Aryee

et al.

Science, Journal Year: 2022, Volume and Issue: 378(6626), P. 1276 - 1277

Published: Dec. 22, 2022

Global methylation changes in aging cells affect cancer risk and tissue homeostasis

Language: Английский

Citations

51