From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Language: Английский

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Drug-induced oxidative stress in cancer treatments: Angel or devil?

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102754 - 102754

Published: May 18, 2023

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one the most significant biological events cancer progression. Cancer cells generally represent a higher level, which suggests dual therapeutic strategy by regulating status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, exhibits great anti-cancer capability, attributing to accumulation within cells, whereas restore homeostasis has been claimed fail several clinical practices. Targeting vulnerability pro-oxidants capable generating excessive reactive oxygen species (ROS) surfaced an important strategy. However, multiple adverse effects caused indiscriminate attacks uncontrolled drug-induced OS on normal tissues and drug-tolerant capacity some certain greatly limit their further applications. Herein, we review representative oxidative drugs summarize side organs, emphasizing that seeking balance between damage value exploiting next-generation OS-based chemotherapeutics.

Language: Английский

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NOX Dependent ROS Generation and Cell Metabolism

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2086 - 2086

Published: Jan. 20, 2023

Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, superoxide anion radical (O2·-) is key redox signaling molecule prominently generated by NADPH oxidase (NOX) enzyme family and mitochondrial electron transport chain. Notably, altered balance deregulated are recognized hallmarks cancer involved in malignant progression resistance to drugs treatment. Since oxidative stress metabolism cells strictly intertwined, this review, we focus on emerging roles NOX enzymes as important modulators metabolic reprogramming cancer. The includes seven isoforms different activation mechanisms, widely expressed several tissues. In particular, dissect contribute NOX1, NOX2, NOX4 modulation highlight their potential role new therapeutic target for tumor rewiring.

Language: Английский

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Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)

Published: April 21, 2023

Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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New Treatment Paradigms in Primary Biliary Cholangitis

Clinical Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 21(8), P. 2076 - 2087

Published: Feb. 20, 2023

Language: Английский

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Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 633, P. 17 - 19

Published: Nov. 4, 2022

Language: Английский

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Targeting DNA methylation and demethylation in diabetic foot ulcers

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 54, P. 119 - 131

Published: Jan. 25, 2023

Poor wound healing is a significant complication of diabetes, which commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral arterial disease. Diabetic foot ulcers (DFU) are difficult to heal, makes patients susceptible infections can ultimately conduce limb amputation or even death in severe cases. An increasing number studies have found that epigenetic alterations strongly associated with poor diabetes.This work provides insights into the development therapeutics for improving chronic diabetic healing, particularly targeting regulating DNA methylation demethylation DFU. Key scientific concepts review: play an important part via corresponding signaling pathways different breeds cells, including macrophages, vascular endothelial cells keratinocytes. In this review, we describe four main phases their abnormality patients. Furthermore, provided in-depth summary discussion on how regulate types cells; gave brief recent advances applying cellular reprogramming techniques healing.

Language: Английский

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Particulate matter stimulates the NADPH oxidase system via AhR-mediated epigenetic modifications

Environmental Pollution, Journal Year: 2024, Volume and Issue: 347, P. 123675 - 123675

Published: March 4, 2024

Stimulation of human keratinocytes with particulate matter 2.5 (PM2.5) elicits complex signaling events, including a rise in the generation reactive oxygen species (ROS). However, mechanisms underlying PM2.5-induced ROS production remain unknown. Here, we show that is mediated via NADPH oxidase (NOXs) system and Ca2+ pathway. PM2.5 treatment increased expression NOX1, NOX4, calcium-sensitive NOX, dual 1 (DUOX1), epidermal keratinocyte cell line. bound to aryl hydrocarbon receptor (AhR), this promoter regions NOX1 DUOX1, suggesting AhR acted as transcription factor DUOX1. DUOX1 epigenetic modification. Moreover, link between DNA demethylase histone methyltransferase led an elevation mRNA. Interestingly, NOX4 promoted interaction channels within cytoplasmic membrane or endoplasmic reticulum, leading release. The increase intracellular concentration activated responsible for production. Our findings provide evidence PM2.5-mediated ROS-generating network, which serves signal through activation.

Language: Английский

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Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: April 3, 2024

Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and body’s ability to counteract their harmful effects, playing a key role in pathogenesis brain lung-related diseases. This review comprehensively examines intricate mechanisms which oxidative influences cellular molecular pathways, contributing neurodegenerative, cardiovascular, respiratory disorders. Emphasizing detrimental effects on both lung health, we discuss innovative diagnostic biomarkers, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG), potential antioxidant therapies. For these topics, provide insights into future research directions field treatment, including development personalized treatment approaches, discovery validation novel new drug delivery systems. not only provides perspective understanding diseases but also offers for clinical treatments.

Language: Английский

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