Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Language: Английский

Macrophages and T cells in metabolic disorder-associated cancers DOI
Daniel Taranto, Daan J. Kloosterman, Leila Akkari

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

9
Innate immune cells link dietary cues to normal and abnormal metabolic regulation DOI
Peng Zhang, Kosuke Watari, Michael Karin

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: 26(1), P. 29 - 41

Published: Jan. 1, 2025

Language: Английский

Citations

1
Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis DOI Creative Commons
Yutong Li, Xingyu Song,

Yuyang Huang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. In this study, we acquired 731 phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data research by Handan Melike Dönertaş et al. (3,731 cases, 480,867 controls), aggregated statistics of 1,400 blood metabolites UK Biobank 115,078). Bidirectional MR analysis performed explore HD, two-sample multi-variable were conducted identify plasma mediating in HD. addition, sensitivity analyses used evaluate robustness, heterogeneity, horizontal pleiotropy results. Single-cell transcriptome-based exploration key molecule mechanism which regulated differentiation pathogenesis. Co-localization using single-cell eQTL (sc-eQTL) with probe genetically shared effects. Two-sample MRshowed that CD25 on naive-mature B cell, CD8 + NKT thymol sulfate level found have (P < 0.008). The relationship further validated an independent cohort inverse-variance weighted (IVW). cells both negatively correlated 0.05). results remained significant after MR-Egger MR-PRESSO correction for heterogeneity > Multi-variable showed mediated 8.67% 10.4% associations respectively. Moreover, evolution microenvironment, identifying PTPRC, PTK2B, KDM5A TIGIT as participating molecules. molecules had genetic sharing effects (PPH4 0.75, R2 0.8, P 0.05), PTK2B having broadest interval. Current study provides evidence supporting several specific well metabolites. Thymol may increases risk pathogenesis variants inducing progression microenvironment.

Language: Английский

Citations

1
Immune Checkpoints and the Immunology of Liver Fibrosis DOI Creative Commons
Ioannis Tsomidis, Argyro Voumvouraki, Elias Kouroumalis

et al.

Livers, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5

Published: Jan. 27, 2025

Liver fibrosis is a very complicated dynamic process where several immune cells are involved. Both innate and adaptive immunity implicated, their interplay always present. Multi-directional interactions between liver macrophages, hepatic stellate (HSCs), cells, cytokines important for the induction perpetuation of fibrosis. Detailed studies proteomics transcriptomics have produced new evidence role individual in cirrhosis. Most these controlled by various checkpoints whose main function to maintain homeostasis implicated cells. Recent indicates that involved In particular, programmed cell death protein 1 (PD-1), death-ligand (PD-L1), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) been investigated, particularly after availability checkpoint inhibitors. Their activation leads exhaustion CD4+ve CD8+ve promotion this review, current pathogenesis immunological abnormalities discussed. The recent data on involvement identified as possible targets future interventions.

Language: Английский

Citations

1
Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment DOI Creative Commons

Haoqiang Yang,

Jinghui Li, Yuanjie Niu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Metabolic reprogramming is one of the major biological features malignant tumors, playing a crucial role in initiation and progression cancer. The tumor microenvironment consists various non-cancer cells, such as hepatic stellate cancer-associated fibroblasts (CAFs), immune well extracellular matrix soluble substances. In liver cancer, metabolic not only affects its own growth survival but also interacts with other cells by influencing expression release metabolites cytokines (such lactate, PGE2, arginine). This interaction leads to acidification restricts uptake nutrients resulting competition symbiosis. At same time, neighboring during proliferation differentiation processes impacts immunity. article provides comprehensive overview crosstalk between cancer their microenvironment, deepening our understanding relevant findings pathways. contributes further regulation development evasion mechanisms while providing assistance advancing personalized therapies targeting pathways for anti-cancer treatment.

Language: Английский

Citations

1
Inflammatory processes involved in NASH-related hepatocellular carcinoma DOI Open Access
Stefania Cannito, Umberto Dianzani, Maurizio Parola

et al.

Bioscience Reports, Journal Year: 2023, Volume and Issue: 43(1)

Published: Jan. 1, 2023

Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide. In recent years nonalcoholic fatty liver disease (NAFLD) becoming a growing HCCs and incidence NAFLD-related expected to further dramatically increase by next decade. Chronic inflammation regarded as driving force NAFLD progression key factor in hepatic carcinogenesis. Hepatic results from persistent stimulation innate immunity response hepatocellular injury gut dysbiosis well activation adaptive immunity. However, relative roles processes HCC are still incompletely characterized. This due complex interplay between different cell populations, which also strongly influenced gut-derived bacterial products, metabolic/nutritional signals. Furthermore, carcinogenic mechanisms NAFLD/NASH appear involve signals mediated hypoxia inducible factors. review discusses data regarding contribution inflammatory cells their possible impact on patient current treatments.

Language: Английский

Citations

19
Learning from the nexus of autoimmunity and cancer DOI Creative Commons
Davide Mangani,

Dandan Yang,

Ana C. Anderson

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(2), P. 256 - 271

Published: Feb. 1, 2023

Language: Английский

Citations

18
Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities DOI Creative Commons
Wen G. Jiang, Weilin Jin, Aman Xu

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(6), P. 2044 - 2071

Published: Jan. 1, 2024

Cholesterol is crucial for cell survival and growth, dysregulation of cholesterol homeostasis has been linked to the development cancer. The tumor microenvironment (TME) facilitates crosstalk between metabolism TME contributes tumorigenesis progression. Targeting demonstrated significant antitumor effects in preclinical clinical studies. In this review, we discuss regulatory mechanisms impact its on hallmarks We also describe how reprograms across seven specialized microenvironments. Furthermore, potential targeting as a therapeutic strategy tumors. This approach not only exerts monotherapy combination therapy but mitigates adverse associated with conventional therapy. Finally, outline unresolved questions suggest avenues future investigations relation

Language: Английский

Citations

8
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma DOI Creative Commons

Rongrong Fu,

Wenqing Xue,

Jingjie Liang

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(5)

Published: May 9, 2024

Cholesterol metabolism reprogramming is one of the significant characteristics hepatocellular carcinoma (HCC). increases risk epithelial-mesenchymal transition (EMT) in cancer. Sterol O-acyltransferases 1 (SOAT1) maintains cholesterol homeostasis. However, exact mechanistic contribution SOAT1 to EMT HCC remains unclear. Here we demonstrated that positively related poor prognosis HCC, markers and promoted cell migration invasion vitro, which was mediated by increased plasmalemma esters accumulation. Furthermore, reported disrupted homeostasis accelerate tumorigenesis development xenograft NAFLD-HCC. Also, detected nootkatone, a sesquiterpene ketone, inhibited targeting vitro vivo. Collectively, our finding indicated promotes contributes hepatocarcinogenesis increasing esterification, suppressed efficiently nootkatone. This study potential biomarker therapeutic target NAFLD-HCC SOAT1-targeting inhibitors are expected be new treatment for HCC.

Language: Английский

Citations

7
Lipid Metabolism as a Potential Target of Liver Cancer DOI Creative Commons
Kangze Wu, Feizhuan Lin

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 327 - 346

Published: Feb. 1, 2024

Abstract: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving prognosis HCC remains formidable challenge. It is noteworthy that lipid metabolism plays pivotal role onset, development, progression cells. Existing research indicates potential application targeting HCC. This review aims to thoroughly explore alterations HCC, offering detailed account advantages associated innovative therapeutic strategies metabolism. Targeting holds promise for potentially enhancing Keywords: cholesterol, fatty acid, hepatocellular carcinoma, uptake, catabolism, synthesis

Language: Английский

Citations

6