Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies

Pharmacological Research, Journal Year: 2025, Volume and Issue: 215, P. 107726 - 107726

Published: April 4, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of with limited treatment options and poor prognosis. The gut microbiota, a diverse community microorganisms in the gastrointestinal tract, plays crucial role regulating immune responses through gut-immune axis. Recent studies have highlighted its significant impact on TNBC progression efficacy immunotherapies. This review examines interactions between microbiota system TNBC, focusing key cells pathways involved tumor immunity. It also explores modulation strategies, including probiotics, prebiotics, dietary interventions, fecal transplantation, as potential methods to enhance immunotherapeutic outcomes. Understanding these mechanisms offers promising avenues for improving patient prognosis TNBC.

Language: Английский

Metabolic reprogramming in viral infections: the interplay of glucose metabolism and immune responses

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Metabolic reprogramming is an important player within the immune response to viral infections, allowing cells fine-tune their energy production and biosynthetic requirements while it actively working restrict pathogen access essential nutrients. Particularly, glucose metabolism, which appears be one of regulators function, affects cell activation, cytokine secretion, restriction. This review explores mechanisms metabolic during with a specific emphasis on metabolism. We discussed key cytokines involved in orchestrating this process influence pre-existing disorders efficiency. Furthermore, we introduced emerging therapeutic strategies that target metabolism enhance antiviral immunity improve disease outcomes. A deeper understanding interaction between could promising for development novel immunometabolic targets against infections.

Language: Английский

Immune infiltration and protective roles of FGF21 in liver injury, obesity, and hepatocellular cancer

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: June 5, 2025

Language: Английский